Melanoma cells with acquired resistance to vemurafenib have decreased autophagic flux and display enhanced ability to transfer resistance.
Autophagy
BRAF(V600E) mutation
Melanoma
Resistance transfer
Vemurafenib
Journal
Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
27
12
2022
revised:
31
05
2023
accepted:
28
06
2023
medline:
7
8
2023
pubmed:
8
7
2023
entrez:
7
7
2023
Statut:
ppublish
Résumé
Over the last years, the incidence of melanoma, the deadliest form of skin cancer, has risen significantly. Nearly half of the melanoma patients exhibit the BRAF
Identifiants
pubmed: 37419396
pii: S0925-4439(23)00167-9
doi: 10.1016/j.bbadis.2023.166801
pii:
doi:
Substances chimiques
Vemurafenib
207SMY3FQT
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Sulfonamides
0
Indoles
0
Protein Kinase Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
166801Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.