Melatonin, vitamins and minerals supplements for the treatment of Covid-19 and Covid-like illness: A prospective, randomized, double-blind multicenter study.
Covid-19
Emergency department
Melatonin
Vitamin C
Vitamin D
Zinc
Journal
Explore (New York, N.Y.)
ISSN: 1878-7541
Titre abrégé: Explore (NY)
Pays: United States
ID NLM: 101233160
Informations de publication
Date de publication:
20 Jun 2023
20 Jun 2023
Historique:
received:
05
04
2023
revised:
09
06
2023
accepted:
19
06
2023
medline:
8
7
2023
pubmed:
8
7
2023
entrez:
7
7
2023
Statut:
aheadofprint
Résumé
Melatonin, zinc, and multivitamins are among most recommended supplements in the fight against coronavirus disease 2019 (COVID-19). We aimed to examine the efficacy and safety of this association in the treatment of COVID-19 and COVID-like illnesses. We conducted a multicenter prospective, randomized, double-blind, controlled trial. Patients with no medical history consulting the emergency department for covid and covid-like illness and who were not hospitalized were included. Patients were assigned in a 1:1 ratio to the treatment or the placebo group. The primary outcome was studying the effectiveness of zinc multivitamin supplement and melatonin in the treatment of COVID and -like illnesses symptoms' according to the time from randomization to clinical improvement. The pre-specified secondary outcomes were date of disappearance of symptoms present on admission, appearance of an adverse effect due to the administration of the treatment, number of patients developing complications, requiring hospitalization, requiring respiratory support. One hundred sixty four patients were eligible for the study and were randomized to either the treatment group or the placebo group. Overall, 128 of the 164 patients had a PCR for SARS-CoV-2, yielding a positive PCR result in 49.1% of them. Regarding the disappearance of all initial presenting symptoms: on the Our results showed that daily doses of Melatonin, zinc and vitamins did significantly reduce the duration of symptoms accelerating its disappearance among patients consulting with COVID-19 or COVID-19 like illness.
Sections du résumé
BACKGROUND
BACKGROUND
Melatonin, zinc, and multivitamins are among most recommended supplements in the fight against coronavirus disease 2019 (COVID-19). We aimed to examine the efficacy and safety of this association in the treatment of COVID-19 and COVID-like illnesses.
METHODS
METHODS
We conducted a multicenter prospective, randomized, double-blind, controlled trial. Patients with no medical history consulting the emergency department for covid and covid-like illness and who were not hospitalized were included. Patients were assigned in a 1:1 ratio to the treatment or the placebo group. The primary outcome was studying the effectiveness of zinc multivitamin supplement and melatonin in the treatment of COVID and -like illnesses symptoms' according to the time from randomization to clinical improvement. The pre-specified secondary outcomes were date of disappearance of symptoms present on admission, appearance of an adverse effect due to the administration of the treatment, number of patients developing complications, requiring hospitalization, requiring respiratory support.
RESULTS
RESULTS
One hundred sixty four patients were eligible for the study and were randomized to either the treatment group or the placebo group. Overall, 128 of the 164 patients had a PCR for SARS-CoV-2, yielding a positive PCR result in 49.1% of them. Regarding the disappearance of all initial presenting symptoms: on the
CONCLUSIONS
CONCLUSIONS
Our results showed that daily doses of Melatonin, zinc and vitamins did significantly reduce the duration of symptoms accelerating its disappearance among patients consulting with COVID-19 or COVID-19 like illness.
Identifiants
pubmed: 37419768
pii: S1550-8307(23)00129-5
doi: 10.1016/j.explore.2023.06.009
pmc: PMC10281695
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Références
Molecules. 2020 Nov 16;25(22):
pubmed: 33207753
Drugs Ther Perspect. 2020;36(12):565-567
pubmed: 33041621
Trop Med Int Health. 2009 Feb;14(2):143-8
pubmed: 19207174
Maturitas. 2021 Jan;143:1-9
pubmed: 33308613
JAMA Netw Open. 2021 Feb 1;4(2):e210369
pubmed: 33576820
Compr Rev Food Sci Food Saf. 2014 Jul;13(4):358-376
pubmed: 33412710
Mol Biol Rep. 2022 May;49(5):4061-4068
pubmed: 35389130
J Travel Med. 2022 May 31;29(3):
pubmed: 35137210
Int J Infect Dis. 2022 Jan;114:79-84
pubmed: 34653660
J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X211026193
pubmed: 34225463
Lancet Respir Med. 2020 Jul;8(7):659-661
pubmed: 32437646
Bone. 2022 Jan;154:116175
pubmed: 34508882
Lancet. 2022 Mar 5;399(10328):924-944
pubmed: 35202601
Nutrients. 2021 Apr 12;13(4):
pubmed: 33921297
Eur J Endocrinol. 2020 Nov;183(5):R133-R147
pubmed: 32755992
Oxid Med Cell Longev. 2019 Jan 10;2019:4087298
pubmed: 30755784
Clin Infect Dis. 2023 Jan 13;76(2):185-191
pubmed: 36367144
Front Immunol. 2021 Dec 15;12:717816
pubmed: 34975830
Biol Trace Elem Res. 2022 Jun;200(6):2556-2571
pubmed: 34368933
Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2213524119
pubmed: 36048910
Life Sci. 2020 Jun 1;250:117583
pubmed: 32217117
Curr Top Med Chem. 2017;17(4):467-488
pubmed: 27558675
Nutrients. 2020 Dec 27;13(1):
pubmed: 33375422
Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S20-3
pubmed: 12142956
J Viral Hepat. 2018 May;25(5):491-501
pubmed: 29239069
Biomolecules. 2020 Aug 20;10(9):
pubmed: 32825327
Arch Med Res. 2022 Jan;53(1):79-85
pubmed: 34229896
Int J Environ Res Public Health. 2022 Dec 05;19(23):
pubmed: 36498340
Cureus. 2020 Nov 30;12(11):e11779
pubmed: 33409026
J Pineal Res. 2010 Mar;48(2):109-16
pubmed: 20070490
JAMA. 2021 Mar 16;325(11):1053-1060
pubmed: 33595634
Allergy. 2022 May;77(5):1373-1388
pubmed: 34626488
Rev Med Virol. 2020 May;30(3):e2109
pubmed: 32314850
Front Immunol. 2021 Oct 11;12:714170
pubmed: 34707602
BMC Med. 2010 Mar 22;8:17
pubmed: 20307281
J Pineal Res. 2013 Mar;54(2):207-21
pubmed: 23110436
J Steroid Biochem Mol Biol. 2020 Oct;203:105751
pubmed: 32871238
J Med Virol. 2021 May;93(5):3261-3267
pubmed: 33629384