A Multimodal Omics Framework to Empower Target Discovery for Cardiovascular Regeneration.
Cardiovascular regeneration
Heart failure
Myocardial infarction
Single-cell RNA sequencing
Target discovery
Journal
Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220
Informations de publication
Date de publication:
08 Jul 2023
08 Jul 2023
Historique:
accepted:
19
06
2023
medline:
8
7
2023
pubmed:
8
7
2023
entrez:
8
7
2023
Statut:
aheadofprint
Résumé
Ischaemic heart disease is a global healthcare challenge with high morbidity and mortality. Early revascularisation in acute myocardial infarction has improved survival; however, limited regenerative capacity and microvascular dysfunction often lead to impaired function and the development of heart failure. New mechanistic insights are required to identify robust targets for the development of novel strategies to promote regeneration. Single-cell RNA sequencing (scRNA-seq) has enabled profiling and analysis of the transcriptomes of individual cells at high resolution. Applications of scRNA-seq have generated single-cell atlases for multiple species, revealed distinct cellular compositions for different regions of the heart, and defined multiple mechanisms involved in myocardial injury-induced regeneration. In this review, we summarise findings from studies of healthy and injured hearts in multiple species and spanning different developmental stages. Based on this transformative technology, we propose a multi-species, multi-omics, meta-analysis framework to drive the discovery of new targets to promote cardiovascular regeneration.
Identifiants
pubmed: 37421484
doi: 10.1007/s10557-023-07484-7
pii: 10.1007/s10557-023-07484-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s).
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