2,6-Disubstituted 7-(naphthalen-2-ylmethyl)-7H-purines as a new class of potent antitubercular agents inhibiting DprE1.
DprE1
Mycobacterium tuberculosis
Purine
Structure-activity relationships
Tuberculosis
Journal
European journal of medicinal chemistry
ISSN: 1768-3254
Titre abrégé: Eur J Med Chem
Pays: France
ID NLM: 0420510
Informations de publication
Date de publication:
05 Oct 2023
05 Oct 2023
Historique:
received:
04
05
2023
revised:
27
06
2023
accepted:
27
06
2023
medline:
19
7
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
ppublish
Résumé
Phenotypic screening of an in-house library of small molecule purine derivatives against Mycobacterium tuberculosis (Mtb) led to the identification of 2-morpholino-7-(naphthalen-2-ylmethyl)-1,7-dihydro-6H-purin-6-one 10 as a potent antimycobacterial agent with MIC
Identifiants
pubmed: 37421887
pii: S0223-5234(23)00577-9
doi: 10.1016/j.ejmech.2023.115611
pii:
doi:
Substances chimiques
Antitubercular Agents
0
purine
W60KTZ3IZY
Alcohol Oxidoreductases
EC 1.1.-
Purines
0
Bacterial Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115611Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.