Dopaminergic neuroprotective effects of inosine in MPTP-induced parkinsonian mice via brain-derived neurotrophic factor upregulation.
Humans
Mice
Animals
Dopamine
/ metabolism
Neuroprotective Agents
/ therapeutic use
Brain-Derived Neurotrophic Factor
/ metabolism
Up-Regulation
Neurodegenerative Diseases
/ metabolism
Neuroblastoma
Parkinson Disease
/ drug therapy
Dopaminergic Neurons
Substantia Nigra
Inosine
/ pharmacology
Mice, Inbred C57BL
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
/ metabolism
Brain-derived neurotrophic factor
Inosine
MPTP
Parkinson's disease
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
received:
09
02
2023
revised:
03
07
2023
accepted:
04
07
2023
medline:
7
8
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
ppublish
Résumé
Parkinson's disease (PD) is the second most common neurodegenerative disease. However, no curative or modifying therapy is known. Inosine is a purine nucleoside that increases brain-derived neurotrophic factor (BDNF) expression in the brain through adenosine receptors. Herein, we investigated the neuroprotective effects of inosine and elucidated the mechanisms underlying its pharmacological action. Inosine rescued SH-SY5Y neuroblastoma cells from MPP
Identifiants
pubmed: 37422180
pii: S0028-3908(23)00242-3
doi: 10.1016/j.neuropharm.2023.109652
pii:
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Neuroprotective Agents
0
Brain-Derived Neurotrophic Factor
0
Inosine
5A614L51CT
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
9P21XSP91P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109652Informations de copyright
Copyright © 2023. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors state that there are no any financial or any interpersonal conflict of interest that might have appeared to affect the research presented in this study.