Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort.
brain changes
cognitive reserve
dementia
physical activity
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
08 Jul 2023
08 Jul 2023
Historique:
revised:
25
05
2023
received:
20
01
2023
accepted:
29
05
2023
medline:
9
7
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
aheadofprint
Résumé
This study aims to examine whether physical activity moderates the association between biomarkers of brain pathologies and dementia risk. From the Memento cohort, we analyzed 1044 patients with mild cognitive impairment, aged 60 and older. Self-reported physical activity was assessed using the International Physical Activity Questionnaire. Biomarkers of brain pathologies comprised medial temporal lobe atrophy (MTA), white matter lesions, and plasma amyloid beta (Aβ)42/40 and phosphorylated tau181. Association between physical activity and risk of developing dementia over 5 years of follow-up, and interactions with biomarkers of brain pathologies were tested. Physical activity moderated the association between MTA and plasma Aβ42/40 level and increased dementia risk. Compared to participants with low physical activity, associations of both MTA and plasma Aβ42/40 on dementia risk were attenuated in participants with high physical activity. Although reverse causality cannot be excluded, this work suggests that physical activity may contribute to cognitive reserve. Physical activity is an interesting modifiable target for dementia prevention. Physical activity may moderate the impact of brain pathology on dementia risk. Medial temporal lobe atrophy and plasma amyloid beta 42/40 ratio were associated with increased dementia risk especially in those with low level of physical activity.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Foundation Plan Alzheimer
Organisme : French Ministry of Research
Investigateurs
Michèle Allard
(M)
Sandrine Andrieu
(S)
Pierre Anthony
(P)
Christine Astier
(C)
Alexandre Augier
(A)
Nicolas Auguste
(N)
Sophie Auriacombe
(S)
John Avet
(J)
Olivier Bailon
(O)
Fabrice-Guy Barral
(FG)
Jean Barré
(J)
Annick Barthelaix
(A)
Catherine Bayle
(C)
Olivier Beauchet
(O)
Catherine Belin
(C)
Samia Belkacem
(S)
Douraied Ben Salem
(DB)
Karim Bennys
(K)
Géraldine Bera
(G)
Eric Berger
(E)
Marc G Berger
(MG)
Emilie Bergouin
(E)
François Bertin-Hugault
(F)
Guillaume Bertrand
(G)
François-Xavier Bertrand
(FX)
Catherine Beze
(C)
Valérie Boilet
(V)
Stéphanie Bombois
(S)
Alain Bonafé
(A)
Yasmina Boudali
(Y)
Hatem Bouhladour
(H)
Clémence Boully
(C)
Isabelle Bourdel-Marchasson
(I)
Vincent Bouteloup
(V)
Claire Boutet
(C)
Serge Bracard
(S)
Antoine Brangier
(A)
Pierre-Yves Brillet
(PY)
Laure Caillard
(L)
Fabienne Calvas
(F)
Agnès Camus
(A)
Vincent Camus
(V)
Sandrine Canaple
(S)
Antoine Carpentier
(A)
Pascaline Cassagnaud
(P)
Françoise Cattin
(F)
Ludivine Chamard
(L)
Stéphane Chanalet
(S)
Mathieu Chastan
(M)
Sophie Chauvelier
(S)
Valérie Chauvire
(V)
Samia Cheriet
(S)
Anthony Clotagatide
(A)
Emmanuel Cognat
(E)
Lora Cohen
(L)
Jean-Marc Constans
(JM)
Marie-Hélène Coste
(MH)
Jean-Philippe Cottier
(JP)
François Cotton
(F)
Isabelle Couret
(I)
Olivier-François Couturier
(OF)
Pascale Cowppli-Bony
(P)
Véronique Cressot
(V)
Benjamin Crétin
(B)
Keren Danaila
(K)
Jacques Darcourt
(J)
Jean-François Dartigues
(JF)
Ana-Maria Dascalita
(AM)
Renaud David
(R)
Xavier De Petigny
(X)
Delphine De Verbizier-Lonjon
(D)
Marielle Decousus
(M)
Isabelle Defouilloy
(I)
Christine Delmaire
(C)
Julien Delrieu
(J)
Catherine Demuyinck
(C)
Vincent Deramecourt
(V)
Hervé Deramond
(H)
Thomas Desmidt
(T)
Marie-Dominique Desruet
(MD)
Julien Detour
(J)
Agnès Devendeville
(A)
Mira Didic
(M)
Maritchu Doireau
(M)
Antonio Dos Santos
(AD)
Patrice Douillet
(P)
Foucaud Du Boisgueheneuc
(FD)
Delphine Dubail
(D)
Laure Ducroq-Ducastaing
(L)
Julien Dumurgier
(J)
Diane Dupuy
(D)
Emmanuelle Duron
(E)
Inna Dygai-Cochet
(I)
Véronique Eder
(V)
Stéphane Epelbaum
(S)
Frédérique Etcharry-Bouyx
(F)
Daniel Fagret
(D)
Catherine Faisant
(C)
Karim Farid
(K)
Denis Fédérico
(D)
Olivier Felician
(O)
Philippe Fernandez
(P)
Pacôme Fosse
(P)
Alexandra Foubert-Samier
(A)
Isabelle Franck
(I)
Monique Galitzky
(M)
Céline Gallazzini-Crepin
(C)
Radka Gantchev
(R)
Laurence Garbarg-Chenon
(L)
Guillaume Gautier
(G)
Emmanuel Gerardin
(E)
Claire Gervais
(C)
Jean-Claude Getenet
(JC)
Nadine Girard
(N)
Fabienne Giraud
(F)
Chantal Girtanner
(C)
Valérie Gissot
(V)
Caroline Grangeon
(C)
Daniel Grucker
(D)
Eric Guedj
(E)
Claude Gueriot
(C)
Yves Guilhermet
(Y)
Rémy Guillevin
(R)
Sophie Haffen
(S)
Didier Hannequin
(D)
Sandrine Harston
(S)
Anne Hitzel
(A)
Caroline Hommet
(C)
Claude Hossein-Foucher
(C)
Fabrice Hubele
(F)
Agnès Jacquin-Piques
(A)
Betty Jean
(B)
Joanne Jenn
(J)
Laure Joly
(L)
Thérèse Jonveaux
(T)
Adrien Julian
(A)
Aurélie Kas
(A)
Anna Kearney-Schwartz
(A)
Alice Keles
(A)
Antony Kelly
(A)
Nathalie Keromnes
(N)
Lejla Koric
(L)
Alexandre Krainik
(A)
Stéphane Kremer
(S)
Florian Labourée
(F)
Franck Lacoeuille
(F)
Francoise Lala
(F)
Chantal Lamy
(C)
Jean-Louis Laplanche
(JL)
Cyrille Launay
(C)
Stéphane Lehericy
(S)
Sylvain Lehmann
(S)
Hermine Lenoir
(H)
Marcel Levy
(M)
Stéphanie Libercier
(S)
Marie-Anne Mackowiak-Cordoliani
(MA)
Eloi Magnin
(E)
Zaza Makaroff
(Z)
Athina Marantidou
(A)
Isabelle Marcet
(I)
Cécilia Marelli
(C)
Sophie Marilier
(S)
Idalie Martin
(I)
Olivier Martinaud
(O)
Catherine Martin-Hunyadi
(C)
Aïcha Medjoul
(A)
Isabelle Merlet
(I)
Danielle Mestas
(D)
Marc-Etienne Meyer
(ME)
Jean-Marc Michel
(JM)
Agnès Michon
(A)
Isabelle Migeon-Duballet
(I)
Karl Mondon
(K)
Clément Morgat
(C)
Véronique Moullart
(V)
Christian Moussard
(C)
Aurélie Mouton
(A)
Izzie Jacques Namer
(IJ)
Georges Niewiadomski
(G)
Guillaume Nivaggioni
(G)
Marie Noblet
(M)
Michel Nonent
(M)
Fati Nourhashemi
(F)
Hélène Oesterle
(H)
Galdric Orvoen
(G)
Pierre Jean Ousset
(PJ)
Amandine Pallardy
(A)
Claire Paquet
(C)
Pierre-Yves Pare
(PY)
Anne Pasco
(A)
Pierre Payoux
(P)
Cécile Pays
(C)
Isabelle Pellegrin
(I)
Rémy Perdrisot
(R)
Bertille Perin
(B)
Christine Perret-Guillaume
(C)
Grégory Petyt
(G)
Nathalie Philippi
(N)
Geneviève Pinganaud
(G)
Matthieu Plichart
(M)
Gabriel Pop
(G)
Michèle Puel
(M)
Mathieu Queneau
(M)
Solène Querellou
(S)
Muriel Quillard-Muraine
(M)
Valérie Quipourt
(V)
Chloé Rachez
(C)
Micheline Razzouk-Cadet
(M)
Anne-Sophie Rigaud
(AS)
Hélène Robin-Ismer
(H)
Mathieu Rodallec
(M)
Yves Rolland
(Y)
Adeline Rollin-Sillaire
(A)
Olivier Rouaud
(O)
Caroline Roubaud
(C)
Isabelle Rouch
(I)
Julie Roux
(J)
Guillaume Sacco
(G)
Pierre-Yves Salaun
(PY)
François Salmon
(F)
Alicia Sanchez
(A)
Maria-Joao Santiago-Ribeiro
(MJ)
Alain Sarciron
(A)
Nathalie Sastre-Hengan
(N)
Mathilde Sauvée
(M)
Christian Scheiber
(C)
Anne-Marie Schneider
(AM)
Franck Semah
(F)
Amélie Serra
(A)
Marie-Laure Seux
(ML)
Hélène Sordet-Guépet
(H)
Maria Eugenia Soto
(ME)
Mathieu Tafani
(M)
Jean-Yves Tanguy
(JY)
Michael Taroux
(M)
Marc Teichmann
(M)
Catherine Terrat
(C)
Jamila Thabet
(J)
Claire Thalamas
(C)
Catherine Thomas-Anterion
(C)
Anne-Cécile Troussière
(AC)
Renata Ursu
(R)
Pierre Vera
(P)
Martine Vercelletto
(M)
Olivier Vercruysse
(O)
Antoine Verger
(A)
Philippe Viau
(P)
Marie-Neige Videau
(MN)
Thierry Voisin
(T)
Nathalie Wagemann
(N)
Aziza Waissi-Sediq
(A)
Jing Xie
(J)
Nathanaëlle Yeni
(N)
Michel Zanca
(M)
Jean Zinszner
(J)
Informations de copyright
© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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