Longitudinal motor decline in dementia with Lewy bodies, Parkinson disease dementia, and Alzheimer's dementia in a community autopsy cohort.
dementia with Lewy bodies
motor trajectories
parkinsonism
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
revised:
04
05
2023
received:
12
01
2023
accepted:
05
05
2023
pmc-release:
01
10
2024
medline:
12
10
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
ppublish
Résumé
We examined the progression of extrapyramidal symptoms and signs in autopsy-confirmed dementia with Lewy bodies (DLB), Parkinson's disease dementia (PDD), and Alzheimer's disease dementia (AD). Longitudinal data were obtained from Arizona Study of Aging and Neurodegenerative Disease, with PDD (n = 98), AD (n = 47) and DLB (n = 48) further sub-grouped as with or without parkinsonism (DLB+ and DLB-). Within-group Unified Parkinson's Disease Rating Scale (UPDRS) -II and UPDRS-III trajectories were analyzed using non-linear mixed effects models. In DLB, 65.6% had parkinsonism. Baseline UPDRS-II and III scores (off-stage) were highest (P < 0.001) for PDD (mean ± SD 14.3 ± 7.8 and 27.4 ± 16.3), followed by DLB+ (6.0 ± 8.8 and 17.2 ± 17.1), DLB- (1.1 ± 1.3 and 3.3 ± 5.5) and AD (3.2 ± 6.1 and 8.2 ± 13.6). Compared to PDD, the DLB+ group had faster UPDRS-III progression over 8-years (Cohen's-d range 0.98 to 2.79, P < 0.001), driven by gait (P < 0.001) and limb bradykinesia (P = 0.02) subscales. Motor deficits progress faster in DLB+ than PDD, providing insights about expected changes in motor function. Dementia with Lewy bodies has faster motor progression than Parkinson's disease dementia Linear and non-linear mixed modeling analysis of longitudinal data was utilized Findings have implications for clinical prognostication and trial design.
Identifiants
pubmed: 37422286
doi: 10.1002/alz.13357
pmc: PMC10592344
mid: NIHMS1919180
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4377-4387Subventions
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NINDS NIH HHS
ID : U24 NS072026
Pays : United States
Informations de copyright
© 2023 the Alzheimer's Association.
Références
J Alzheimers Dis. 2018;64(2):505-513
pubmed: 29889064
J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):358-366
pubmed: 29030419
Neurology. 2020 Apr 28;94(17):743-755
pubmed: 32241955
Brain. 2019 Jul 1;142(7):2051-2067
pubmed: 31111143
Eur J Neurol. 2015 Mar;22(3):457-63
pubmed: 24888502
Lancet Neurol. 2017 May;16(5):390-398
pubmed: 28342649
Brain Sci. 2020 Feb 02;10(2):
pubmed: 32024222
Lancet Neurol. 2020 Feb;19(2):157-169
pubmed: 31519472
Neurology. 2017 Jul 4;89(1):88-100
pubmed: 28592453
Alzheimer Dis Assoc Disord. 2022 Jan-Mar 01;36(1):64-72
pubmed: 34393189
Neurology. 2021 Sep 7;97(10):e1031-e1040
pubmed: 34404743
Neurology. 2014 Jul 29;83(5):406-12
pubmed: 24975862
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Lancet Neurol. 2016 May;15(6):546-8
pubmed: 27302120
Neuropathology. 2015 Aug;35(4):354-89
pubmed: 25619230
PLoS One. 2019 Jun 25;14(6):e0217566
pubmed: 31237877
Neurology. 2020 Jul 14;95(2):e155-e165
pubmed: 32561678
Neuropathol Appl Neurobiol. 2021 Feb;47(1):143-156
pubmed: 32720329
J Neurochem. 2019 Sep;150(5):467-474
pubmed: 30892688
Dement Geriatr Cogn Disord. 2000 Jul-Aug;11(4):219-22
pubmed: 10867448
Mov Disord. 2016 Jul;31(7):947-956
pubmed: 27226141
Parkinsonism Relat Disord. 2015 Dec;21(12):1421-6
pubmed: 26578041
Dement Geriatr Cogn Dis Extra. 2015 May 29;5(2):212-20
pubmed: 26195977
Neurol Clin Pract. 2021 Aug;11(4):e414-e421
pubmed: 34484939
Mov Disord Clin Pract. 2018 Jan-Feb;5(1):47-53
pubmed: 29662921
Arch Clin Neuropsychol. 2017 Nov 1;32(7):786-801
pubmed: 28961866
Mov Disord. 2006 Aug;21(8):1200-7
pubmed: 16673410
Mov Disord. 2016 Nov;31(11):1619-1622
pubmed: 27492190
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
J Parkinsons Dis. 2018;8(4):553-561
pubmed: 30103351
Br J Clin Pharmacol. 2012 Aug;74(2):267-83
pubmed: 22283961
J Geriatr Psychiatry Neurol. 2022 Jul;35(4):527-534
pubmed: 34114509
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
Semin Neurol. 2019 Apr;39(2):274-282
pubmed: 30925619
Mov Disord Clin Pract. 2017 Mar 11;4(4):536-544
pubmed: 30363418
Mov Disord. 2003 Aug;18(8):884-9
pubmed: 12889077
Am J Psychiatry. 1982 Sep;139(9):1136-9
pubmed: 7114305
Mov Disord. 1994 Jan;9(1):76-83
pubmed: 8139608
Sci Rep. 2019 Jan 28;9(1):797
pubmed: 30692568
Neurology. 2000 Mar 14;54(5):1050-8
pubmed: 10720273
Cell Tissue Bank. 2008 Sep;9(3):229-45
pubmed: 18347928
Parkinsonism Relat Disord. 2013 Oct;19(10):889-93
pubmed: 23791519
Mov Disord. 1999 Nov;14(6):947-50
pubmed: 10584668
Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):330-57
pubmed: 22203825
Acta Neuropathol. 2009 Jun;117(6):613-34
pubmed: 19399512
J Neurol. 2013 Jul;260(7):1731-42
pubmed: 23400498
Alzheimers Dement (Amst). 2015 Sep 1;1(3):316-324
pubmed: 26405688
Neurology. 2020 May 19;94(20):e2076-e2087
pubmed: 32332125