Exploration of acupuncture therapy in the treatment of MCI patients with the ApoE ε4 gene based on the brain-gut axis theory.
16S rRNA sequencing
Acupuncture therapy
Apolipoprotein E gene polymorphism
Gut microbiota
Mild cognitive impairment
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
08 Jul 2023
08 Jul 2023
Historique:
received:
25
04
2023
accepted:
28
06
2023
medline:
10
7
2023
pubmed:
9
7
2023
entrez:
8
7
2023
Statut:
epublish
Résumé
Mild cognitive impairment (MCI) is the predementia phase of Alzheimer's disease (AD). The intestinal microbiome is altered in MCI and AD, and apolipoprotein E (ApoE) ε4 gene polymorphism is a risk factor for the progression of MCI to AD. This study aims to investigate the improvement in cognitive function of MCI patients with and without ApoE ε4 due to acupuncture and the changes in gut microbiota community composition and abundance in MCI. This randomized assessor-blind controlled study will enrol MCI patients with and without the ApoE ε4 gene (n = 60/60). Sixty subjects with the ApoE ε4 gene and 60 subjects without the ApoE ε4 gene will be randomly allocated into treatment and control groups in a 1:1 ratio. Intestinal microbiome profiles will be evaluated by 16 S rRNA sequencing of faecal samples and compared between the groups. Acupuncture is an effective method to improve cognitive function in MCI. This study will provide data on the relationship between the gut microbiota and the effectiveness of acupuncture in patients with MCI from a new angle. This study will also provide data on the relationship between the gut microbiota and an AD susceptibility gene by integrating microbiologic and molecular approaches. www.chictr.org.cn , ID: ChiCTR2100043017, recorded on 4 February 2021.
Sections du résumé
BACKGROUND
BACKGROUND
Mild cognitive impairment (MCI) is the predementia phase of Alzheimer's disease (AD). The intestinal microbiome is altered in MCI and AD, and apolipoprotein E (ApoE) ε4 gene polymorphism is a risk factor for the progression of MCI to AD. This study aims to investigate the improvement in cognitive function of MCI patients with and without ApoE ε4 due to acupuncture and the changes in gut microbiota community composition and abundance in MCI.
METHODS
METHODS
This randomized assessor-blind controlled study will enrol MCI patients with and without the ApoE ε4 gene (n = 60/60). Sixty subjects with the ApoE ε4 gene and 60 subjects without the ApoE ε4 gene will be randomly allocated into treatment and control groups in a 1:1 ratio. Intestinal microbiome profiles will be evaluated by 16 S rRNA sequencing of faecal samples and compared between the groups.
RESULTS/CONCLUSIONS
CONCLUSIONS
Acupuncture is an effective method to improve cognitive function in MCI. This study will provide data on the relationship between the gut microbiota and the effectiveness of acupuncture in patients with MCI from a new angle. This study will also provide data on the relationship between the gut microbiota and an AD susceptibility gene by integrating microbiologic and molecular approaches.
TRIAL REGISTRATION
BACKGROUND
www.chictr.org.cn , ID: ChiCTR2100043017, recorded on 4 February 2021.
Identifiants
pubmed: 37422636
doi: 10.1186/s12906-023-04060-2
pii: 10.1186/s12906-023-04060-2
pmc: PMC10329292
doi:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Clinical Trial Protocol
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
227Subventions
Organisme : Zhejiang Hospital
ID : 2020KYA016
Organisme : The second batch of "3060" young outstanding talent projects
ID : 20226030
Organisme : Traditional Chinese Medicine Science and Technology Plan Project
ID : 2020ZA002
Organisme : Construction Plan for the Inheritance Studio of Xiaoqing Jin Famous Chinese Medicine Expert in Zhejiang Province
ID : GZS2021011
Organisme : Construction Plan for the Inheritance Studio of Xiaoqing Jin Famous Chinese Medicine Expert in China
ID : 2022 NO. 75
Informations de copyright
© 2023. The Author(s).
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