Fertility concerns and outcomes in females with anorectal malformations.
ARM
Cloaca
Fertility
Fertility concerns
Fertility quality of life
Journal
Pediatric surgery international
ISSN: 1437-9813
Titre abrégé: Pediatr Surg Int
Pays: Germany
ID NLM: 8609169
Informations de publication
Date de publication:
09 Jul 2023
09 Jul 2023
Historique:
accepted:
29
06
2023
medline:
11
7
2023
pubmed:
9
7
2023
entrez:
9
7
2023
Statut:
epublish
Résumé
To assess fertility concerns and to describe pregnancy outcomes in patients with anorectal malformations (ARM). This is an IRB approved, cross-sectional study of patients in the Adult Colorectal Research Registry who completed reproductive health surveys between November 2021 and August 2022. Patients assigned female at birth with age 18 or older and ARM were included. Sixty-four patients with ARM, age 18 or older, were included. Fertility concerns were reported in 26 (40.6%) patients, 11 of which had seen a fertility specialist, including four who had not yet tried to conceive. Fertility concerns were highest amongst cloaca patients who had not yet tried to conceive (37.5%). 26 (40.6%) patients had tried to conceive, of which 16 (25%) reported fertility problems, most frequently uterine abnormalities and damaged or blocked fallopian tubes. 22 (34.4%) participants were able to conceive and 18 (28.1%) had at least one live birth. Patients with ARM who had concerns of fertility, had better FertiQoL when compared to published reference scores for patients experiencing fertility issues. Providers should be aware of fertility concerns in patients with ARM. Proactive counseling with referrals to a fertility specialist should be considered in patients who desire future fertility.
Identifiants
pubmed: 37422894
doi: 10.1007/s00383-023-05510-1
pii: 10.1007/s00383-023-05510-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
228Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Peña A, Bischoff A (2015) Surgical treatment of colorectal problems in children. Springer, Switzerland. https://doi.org/10.1007/978-3-319-14989-9
doi: 10.1007/978-3-319-14989-9
Stoll C, Alembik Y, Dott B, Roth MP (2007) Associated malformations in patients with anorectal anomalies. Eur J Med Genet 50:281–290. https://doi.org/10.1016/j.ejmg.2007.04.002
doi: 10.1016/j.ejmg.2007.04.002
pubmed: 17572165
Cuschieri A (2002) Anorectal anomalies associated with or as part of other anomalies. Am J Med Genet 110:122–130. https://doi.org/10.1002/ajmg.10371
doi: 10.1002/ajmg.10371
pubmed: 12116249
Bischoff A (2016) The surgical treatment of cloaca. Semin Pediatr Surg 25:102–107. https://doi.org/10.1053/j.sempedsurg.2015.11.009
doi: 10.1053/j.sempedsurg.2015.11.009
pubmed: 26969234
Chan SH, Schwartz BI, Alexander M et al (2015) Pregnancy outcomes in patients with anorectal malformations. J Pediatr Adolesc Gynecol 28:e59. https://doi.org/10.1016/j.jpag.2015.02.064
doi: 10.1016/j.jpag.2015.02.064
Huibregtse ECP, Draaisma JMT, Hofmeester MJ et al (2014) The influence of anorectal malformations on fertility: a systematic review. Pediatr Surg Int 30:773–781. https://doi.org/10.1007/s00383-014-3535-5
doi: 10.1007/s00383-014-3535-5
pubmed: 24969818
Reppucci ML, Alaniz VI, Wehrli LA et al (2022) Reproductive and family building considerations for female patients with anorectal and urogenital malformations. J Pediatr Surg. https://doi.org/10.1016/j.jpedsurg.2022.09.004
doi: 10.1016/j.jpedsurg.2022.09.004
pubmed: 36411111
pmcid: 9595415
Chan YY, Jayaprakasan K, Zamora J et al (2011) The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Hum Reprod Update 17:761–771. https://doi.org/10.1093/humupd/dmr028
doi: 10.1093/humupd/dmr028
pubmed: 21705770
pmcid: 3191936
Boivin J, Takefman J, Braverman A (2011) The fertility quality of life (FertiQoL) tool: development and general psychometric properties. Hum Reprod 26:2084–2091. https://doi.org/10.1093/humrep/der171
doi: 10.1093/humrep/der171
pubmed: 21665875
pmcid: 3137391
Judd-Glossy L, Ariefdjohan M, Ketzer J et al (2022) Long-term outcomes of adult patients following surgery for congenital colorectal conditions: analysis of psychosocial functioning. Pediatr Surg Int 38:1685–1692. https://doi.org/10.1007/s00383-022-05212-0
doi: 10.1007/s00383-022-05212-0
pubmed: 36127514
Harris PA, Taylor R, Thielke R et al (2009) Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377–381. https://doi.org/10.1016/j.jbi.2008.08.010
doi: 10.1016/j.jbi.2008.08.010
pubmed: 18929686
Boivin J, Takefman J, Braverman A (2011) The fertility quality of life (FertiQoL) tool: development and general psychometric properties. Fertil Steril 96:409-415.e3. https://doi.org/10.1016/j.fertnstert.2011.02.046
doi: 10.1016/j.fertnstert.2011.02.046
pubmed: 21458806
pmcid: 7094343
Breech L (2016) Gynecologic concerns in patients with cloacal anomaly. Semin Pediatr Surg 25:90–95. https://doi.org/10.1053/j.sempedsurg.2015.11.006
doi: 10.1053/j.sempedsurg.2015.11.006
pubmed: 26969232
Breech L (2010) Gynecologic concerns in patients with anorectal malformations. Semin Pediatr Surg 19:139–145. https://doi.org/10.1053/j.sempedsurg.2009.11.019
doi: 10.1053/j.sempedsurg.2009.11.019
pubmed: 20307850