[Pathophysiology of myelodysplastic syndromes].

Physiopathologie des syndromes myélodysplasiques.
Humans Hematopoiesis / genetics Myelodysplastic Syndromes / genetics Bone Marrow Leukemia Mutation
Erythropoiesis Mutation Mutations Myelodysplastic syndrome Splicing Syndromes myélodysplasiques Traduction Translation Épissage Érythropoïèse

Journal

Bulletin du cancer
ISSN: 1769-6917
Titre abrégé: Bull Cancer
Pays: France
ID NLM: 0072416

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 09 01 2023
accepted: 15 02 2023
medline: 13 11 2023
pubmed: 10 7 2023
entrez: 9 7 2023
Statut: ppublish

Résumé

During aging, the onset of mutations at low frequency in hematopoietic cells or clonal hematopoiesis of indeterminate significance favors the evolution towards hemopathies such as myelodysplastic syndromes or acute leukemias, but also cardiovascular diseases and other pathologies. Acute or chronic inflammation related to age influences the clonal evolution and the immune response. Conversely, mutated hematopoietic cells create an inflammatory bone marrow environment facilitating their expansion. Various pathophysiological mechanisms depending on the type of mutation produce the diversity of phenotypes. Identifying factors affecting clonal selection is mandatory to improve patient care.

Identifiants

DOI: 10.1016/j.bulcan.2023.02.026 PMID: 37423830
pubmed: 37423830
pii: S0007-4551(23)00281-3
doi: 10.1016/j.bulcan.2023.02.026
pii:
doi:

Types de publication

English Abstract Journal Article Review

Langues

fre

Sous-ensembles de citation

IM

Pagination

1097-1105

Informations de copyright

Copyright © 2023 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Auteurs

Michaela Fontenay (M)

Assistance publique-Hôpitaux de Paris, université Paris Cité, hôpital Cochin, laboratoire d'hématologie, Inserm, Institut Cochin, Paris, France. Electronic address: michaela.fontenay@aphp.fr.

Ismael Boussaid (I)

Assistance publique-Hôpitaux de Paris, université Paris Cité, hôpital Cochin, laboratoire d'hématologie, Inserm, Institut Cochin, Paris, France.

Nicolas Chapuis (N)

Assistance publique-Hôpitaux de Paris, université Paris Cité, hôpital Cochin, laboratoire d'hématologie, Inserm, Institut Cochin, Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › [Pathophysiology of myelodysplastic syndromes].
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › [Pathophysiology of myelodysplastic syndromes].
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Maladies de la moelle osseuse › Syndromes myélodysplasiques › [Pathophysiology of myelodysplastic syndromes].
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › [Pathophysiology of myelodysplastic syndromes].
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Leucémies › [Pathophysiology of myelodysplastic syndromes].
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › [Pathophysiology of myelodysplastic syndromes].