Whole-brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice.
glutamatergic neurons
lateral periaqueductal gray
monosynaptic inputs
rabies virus
Journal
CNS neuroscience & therapeutics
ISSN: 1755-5949
Titre abrégé: CNS Neurosci Ther
Pays: England
ID NLM: 101473265
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
26
05
2023
received:
30
03
2023
accepted:
24
06
2023
medline:
27
11
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
The lateral periaqueductal gray (LPAG), which mainly contains glutamatergic neurons, plays an important role in social responses, pain, and offensive and defensive behaviors. Currently, the whole-brain monosynaptic inputs to LPAG glutamatergic neurons are unknown. This study aims to explore the structural framework of the underlying neural mechanisms of LPAG glutamatergic neurons. This study used retrograde tracing systems based on the rabies virus, Cre-LoxP technology, and immunofluorescence analysis. We found that 59 nuclei projected monosynaptic inputs to the LPAG glutamatergic neurons. In addition, seven hypothalamic nuclei, namely the lateral hypothalamic area (LH), lateral preoptic area (LPO), substantia innominata (SI), medial preoptic area, ventral pallidum, posterior hypothalamic area, and lateral globus pallidus, projected most densely to the LPAG glutamatergic neurons. Notably, we discovered through further immunofluorescence analysis that the inputs to the LPAG glutamatergic neurons were colocalized with several markers related to important neurological functions associated with physiological behaviors. The LPAG glutamatergic neurons received dense projections from the hypothalamus, especially nuclei such as LH, LPO, and SI. The input neurons were colocalized with several markers of physiological behaviors, which show the pivotal role of glutamatergic neurons in the physiological behaviors regulation by LPAG.
Identifiants
pubmed: 37424163
doi: 10.1111/cns.14338
pmc: PMC10651995
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4147-4159Subventions
Organisme : The National Key Research and Development Program of China
ID : 2022YFA1604504
Organisme : The STI 2030-major project
ID : 2021ZD0203400
Organisme : The National Natural Science Foundation of China
ID : 82171479
Organisme : The National Natural Science Foundation of China
ID : 82020108014
Organisme : The National Natural Science Foundation of China
ID : 32070984
Organisme : Shanghai Science and Technology Innovation Action Plan Laboratory Animal Research Project
ID : 201409001800
Organisme : Program for Shanghai Outstanding Academic Leaders
Organisme : Shanghai Municipal Science and Technology Major Project, and ZJLab, and Shanghai Center for Brain Science and Brain-inspired Technology
ID : 2018SHZDZX01
Organisme : Lingang Laboratory & National Key Laboratory of Human Factors Engineering Joint Grant
ID : LG-TKN-202203-01
Informations de copyright
© 2023 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
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