Teratogenesis and the epigenetic programming of congenital defects: Why paternal exposures matter.
birth defects
congenital malformations
epigenetics
paternal
paternal effect
programming
sperm
teratogen
Journal
Birth defects research
ISSN: 2472-1727
Titre abrégé: Birth Defects Res
Pays: United States
ID NLM: 101701004
Informations de publication
Date de publication:
15 Nov 2023
15 Nov 2023
Historique:
revised:
16
06
2023
received:
12
01
2023
accepted:
23
06
2023
medline:
29
11
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
Until recently, clinicians and researchers did not realize paternal exposures could impact child developmental outcomes. Indeed, although there is growing recognition that sperm carry a large amount of non-genomic information and that paternal stressors influence the health of the next generation, toxicologists are only now beginning to explore the role paternal exposures have in dysgenesis and the incidence of congenital malformations. In this commentary, I will briefly summarize the few studies describing congenital malformations resulting from preconception paternal stressors, argue for the theoretical expansion of teratogenic perspectives into the male preconception period, and discuss some of the challenges in this newly emerging branch of toxicology. I argue that we must consider gametes the same as any other malleable precursor cell type and recognize that environmentally-induced epigenetic changes acquired during the formation of the sperm and oocyte hold equal teratogenic potential as exposures during early development. Here, I propose the term epiteratogen to reference agents acting outside of pregnancy that, through epigenetic mechanisms, induce congenital malformations. Understanding the interactions between the environment, the essential epigenetic processes intrinsic to spermatogenesis, and their cumulative influences on embryo patterning is essential to addressing a significant blind spot in the field of developmental toxicology.
Substances chimiques
Teratogens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1825-1834Subventions
Organisme : NIAAA NIH HHS
ID : R01AA028219
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01AA028219
Pays : United States
Informations de copyright
© 2023 The Author. Birth Defects Research published by Wiley Periodicals LLC.
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