Targeting hepatitis B vaccine escape using immunogenetics in Bangladeshi infants.

Genome-wide association studies escape variants hepatitis B virus human leukocyte antigen major histocompatibility complex vaccination

Journal

medRxiv : the preprint server for health sciences
Titre abrégé: medRxiv
Pays: United States
ID NLM: 101767986

Informations de publication

Date de publication:
29 Jun 2023
Historique:
pubmed: 10 7 2023
medline: 10 7 2023
entrez: 10 7 2023
Statut: epublish

Résumé

Hepatitis B virus (HBV) vaccine escape mutants (VEM) are increasingly described, threatening progress in control of this virus worldwide. Here we studied the relationship between host genetic variation, vaccine immunogenicity and viral sequences implicating VEM emergence. In a cohort of 1,096 Bangladeshi children, we identified human leukocyte antigen (HLA) variants associated with response vaccine antigens. Using an HLA imputation panel with 9,448 south Asian individuals

Identifiants

DOI: 10.1101/2023.06.26.23291885 PMID: 37425840 PMC: PMC10327284
pubmed: 37425840
doi: 10.1101/2023.06.26.23291885
pmc: PMC10327284
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI043596
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI026649
Pays : United States

Déclaration de conflit d'intérêts

Competing interests: JBR’s institution has received investigator-initiated grant funding from Eli Lilly, GlaxoSmithKline and Biogen for projects unrelated to this research. He is the CEO of 5 Prime Sciences Inc (www.5primesciences.com).

Auteurs

Guillaume Butler-Laporte (G)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Division of Infectious Diseases, McGill University Health Centre, Montréal, Québec, Canada.

Kathryn Auckland (K)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

Zannatun Noor (Z)

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Mamun Kabir (M)

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Masud Alam (M)

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Tommy Carstensen (T)

Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom.
Queen Mary University of London, London, United Kingdom.

Genevieve L Wojcik (GL)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Amanda Y Chong (AY)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

Cristina Pomilla (C)

Wellcome Trust Sanger Institute, University of Cambridge, Hinxton, United Kingdom.

Janelle A Noble (JA)

Children's Hospital Oakland Research Institute, Oakland, California, USA.
Department of Pediatrics, University of California, San Francisco, California, USA.

Shana L McDevitt (SL)

Media Labs, Inc. Alameda, CA, USA.

Gaby Smits (G)

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Susan Wareing (S)

Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.

Fiona Rm van der Klis (FR)

National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

Katie Jeffery (K)

Microbiology Department, John Radcliffe Hospital, Oxford University NHS Foundation Trust, Oxford, UK.

Beth D Kirkpatrick (BD)

Department of Microbiology and Molecular Genetics, Vaccine Testing Center, University of Vermont College of Medicine, Vermont, USA.

Sodiomon Sirima (S)

Groupe de Recherche Action en Santé (GRAS) 06 BP 10248 Ouagadougou, Burkina Faso.

Shabir Madhi (S)

South African Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, University of the Witwatersrand, Johannesburg, South Africa.

Alison Elliott (A)

Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

J Brent Richards (JB)

Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada.
Department of Human Genetics, McGill University, Montréal, Québec, Canada.
5 Prime Sciences Inc, Montreal, Quebec, Canada.
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada.
Department of Twin Research, King's College London, London, United Kingdom.

Adrian Vs Hill (AV)

The Jenner Institute, University of Oxford, Oxford, United Kingdom.

Priya Duggal (P)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Manjinder S Sandhu (MS)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom.

Rashidul Haque (R)

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

William A Petri (WA)

Department of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA.

Alexander J Mentzer (AJ)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

Classifications MeSH