Cell Type- and Tissue-specific Enhancers in Craniofacial Development.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
26 Jun 2023
Historique:
pubmed: 10 7 2023
medline: 10 7 2023
entrez: 10 7 2023
Statut: epublish

Résumé

The genetic basis of craniofacial birth defects and general variation in human facial shape remains poorly understood. Distant-acting transcriptional enhancers are a major category of non-coding genome function and have been shown to control the fine-tuned spatiotemporal expression of genes during critical stages of craniofacial development

Identifiants

DOI: 10.1101/2023.06.26.546603 PMID: 37425964 PMC: PMC10327103
pubmed: 37425964
doi: 10.1101/2023.06.26.546603
pmc: PMC10327103
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NHGRI NIH HHS
ID : R01 HG003988
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028599
Pays : United States
Organisme : NIDCR NIH HHS
ID : U01 DE024427
Pays : United States
Organisme : Medical Research Council
ID : MR/R006237/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom

Déclaration de conflit d'intérêts

Declaration of Interests Bing Ren is a co-founder of Arima Genomics, Inc, and Epigenome Technologies, Inc.

Auteurs

Sudha Sunil Rajderkar (SS)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Kitt Paraiso (K)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Maria Luisa Amaral (ML)

Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA, USA.

Michael Kosicki (M)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Laura E Cook (LE)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Fabrice Darbellay (F)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.

Cailyn H Spurrell (CH)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Marco Osterwalder (M)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Department for BioMedical Research, University of Bern, 3008 Bern, Switzerland.

Yiwen Zhu (Y)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Han Wu (H)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Sarah Yasmeen Afzal (SY)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Lucile Packard Children's Hospital, Stanford University, Stanford, CA 94304.

Matthew J Blow (MJ)

U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Guy Kelman (G)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
The Jerusalem Center for Personalized Computational Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Iros Barozzi (I)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Center for Cancer Research, Medical University of Vienna, Borschkegasse 8a 1090, Vienna, Austria.
Department of Surgery and Cancer, Imperial College London, London, UK.

Yoko Fukuda-Yuzawa (Y)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
University Research Management Center, Tohoku University, Sendai, Miyagi, 980-8577, Japan.

Jennifer A Akiyama (JA)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Veena Afzal (V)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Stella Tran (S)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Ingrid Plajzer-Frick (I)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Catherine S Novak (CS)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Momoe Kato (M)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Riana D Hunter (RD)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
UC San Francisco, Division of Experimental Medicine, 1001 Potrero Ave, San Francisco, CA 94110.

Kianna von Maydell (K)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.

Allen Wang (A)

Center for Epigenomics, University of California San Diego School of Medicine, La Jolla, CA, USA.

Lin Lin (L)

Center for Epigenomics, University of California San Diego School of Medicine, La Jolla, CA, USA.

Sebastian Preissl (S)

Center for Epigenomics, University of California San Diego School of Medicine, La Jolla, CA, USA.
Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Steven Lisgo (S)

Human Developmental Biology Resource, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.
Newcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle, NE1 3BZ, UK.

Bing Ren (B)

Institute of Genome Medicine, Moores Cancer Center, University of California, San Diego School of Medicine, La Jolla, CA, USA.

Diane E Dickel (DE)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Octant Inc., Emeryville, CA 94608, USA.

Len A Pennacchio (LA)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA.
Comparative Biochemistry Program, University of California, Berkeley, CA 94720, USA.

Axel Visel (A)

Environmental Genomics & System Biology Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA.
U.S. Department of Energy Joint Genome Institute, 1 Cyclotron Road, Berkeley, CA 94720, USA.
School of Natural Sciences, University of California, Merced, Merced, California, USA.

Classifications MeSH