Lemon-derived nanovesicles achieve antioxidant and anti-inflammatory effects activating the AhR/Nrf2 signaling pathway.
Cell biology
Immunology
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jul 2023
21 Jul 2023
Historique:
received:
01
02
2023
revised:
20
04
2023
accepted:
01
06
2023
medline:
10
7
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
epublish
Résumé
In the last years, extracellular vesicles (EVs) from different plant matrices have been isolated and gained the interest of the scientific community for their intriguing biological properties. In this study, we isolated and characterized nanovesicles from lemon juice (LNVs) and evaluated their antioxidant effects. We tested LNV antioxidant activity using human dermal fibroblasts that were pre-treated with LNVs for 24 h and then stimulated with hydrogen peroxide (H
Identifiants
pubmed: 37426343
doi: 10.1016/j.isci.2023.107041
pii: S2589-0042(23)01118-5
pmc: PMC10329147
doi:
Types de publication
Journal Article
Langues
eng
Pagination
107041Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest that could be perceived as prejudicing the impartiality of the research reported. The authors Raimondo, Conigliaro, and Alessandro are co-founders of the Academic SpinOff of the University of Palermo, Navhetec, which does not have any role in this article. Navhetec has not provided any product to be used for any experimental procedures described in the article. The same authors are inventors of the Italian patents 102019000005090 and 102015902344749. Mauro Manno is co-founder of EVE—The Biofactory, a Spin-Off of the Italian National Research Council (CNR), which does not have any role in this article.
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