Measurement and correlation of solubility data for deferiprone in propylene glycol and 2-propanol at different temperatures.
Binary solvent mixtures
Cosolvency models
Deferiprone
Thermodynamics
solubility
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
received:
24
04
2023
revised:
15
06
2023
accepted:
15
06
2023
medline:
10
7
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
epublish
Résumé
This investigation dealt with the thermodynamic properties, saturated solubility values, and solvation behavior of deferiprone as an oral iron chelator agent in non-aqueous mixtures of propylene glycol and 2-propanol using experimental measurements and mathematical correlations. The solubility of deferiprone demonstrated a positive correlation with both temperature and propylene glycol mass fraction. Four mathematical models were employed to correlate the solid-liquid equilibrium data, and the low mean relative deviation values of less than 3.6% illustrate the good agreement of computed data with the experimental data. The apparent thermodynamic behavior of deferiprone dissolution was also investigated according to van't Hoff and Gibbs equation.
Identifiants
pubmed: 37426787
doi: 10.1016/j.heliyon.2023.e17402
pii: S2405-8440(23)04610-8
pmc: PMC10329119
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e17402Informations de copyright
© 2023 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper
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