Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle.
amodiaquine
infectious disease
malaria
organometallics
quinoline
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
02 Oct 2023
02 Oct 2023
Historique:
received:
23
05
2023
medline:
4
10
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with antimalarial quinolines to be used as chemical tools to overcome the disadvantages of quinolines, improving their bioactive speciation, cellular distribution, and subsequently broadening the spectrum of activity to multiple stages of the complex Plasmodium life cycle. In this study, four novel complexes of ruthenium(II)- and gold(I)-containing amodiaquine (AQ) were synthesized, and a careful chemical characterization revealed the precise coordination site of AQ to the metals. Their speciation in solution was investigated, demonstrating the stability of the quinoline-metal bond. Ru
Identifiants
pubmed: 37427863
doi: 10.1002/chem.202301642
doi:
Substances chimiques
Antimalarials
0
Amodiaquine
220236ED28
Coordination Complexes
0
Quinolines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202301642Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
ID : 54829.632.62060.05032021
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 16/23130-5, 21/02522-0, and 17/15850-0
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 305388/2022-3
Organisme : Fundação Oswaldo Cruz
ID : 002-FIO-20-2-25
Informations de copyright
© 2023 Wiley-VCH GmbH.
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