Heart Disease and Microgravity: The Dawn of a New Medical Era?: A Narrative Review.
Journal
Cardiology in review
ISSN: 1538-4683
Titre abrégé: Cardiol Rev
Pays: United States
ID NLM: 9304686
Informations de publication
Date de publication:
10 Jul 2023
10 Jul 2023
Historique:
medline:
10
7
2023
pubmed:
10
7
2023
entrez:
10
7
2023
Statut:
aheadofprint
Résumé
After a decline in interest in space missions following the cessation of the Apollo missions, there has been a recent resurgence. Activities on the International Space Station have raised awareness of a positive resumption of space travel to more challenging destinations such as Mars and a possible adaptation of human life on the Moon. The biological and physiological studies conducted on these stations in low Earth orbit are crucial in familiarizing humanity with the potential problems that can arise during long journeys. Cosmic rays and microgravity are the 2 main negative phenomena in space flights. Microgravity in the interplanetary environment plays a special role in altering normal organic processes. These studies are compared to studies conducted on Earth with laboratory technologies that mimic the space environment. To date, the molecular and physiological adaptations of the human body to this unnatural environment are very poor. The aim of this review is therefore to provide an overview of the most important findings on the molecular and physiological anomalies that develop during microgravity in short and long space flights.
Identifiants
pubmed: 37428118
doi: 10.1097/CRD.0000000000000581
pii: 00045415-990000000-00128
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure: The authors have no conflicts of interest to report.
Références
Kapitonova MY, Muid S, Froemming GR, et al. Real space flight travel is associated with ultrastructural changes, cytoskeletal disruption and premature senescence of HUVEC. Malays J Pathol. 2012;34:103–113.
Kapitonova MY, Kuznetsov SL, Froemming GR, et al. Effects of space mission factors on the morphology and function of endothelial cells. Bull Exp Biol Med. 2013;154:796–801.
Ma X, Sickmann A, Pietsch J, et al. Proteomic differences between microvascular endothelial cells and the EA.hy926 cell line forming three-dimensional structures. Proteomics. 2014;14:689–698.
Liu H, Wang ZC, Bai YG, et al. Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-kappaB activation. Clin Exp Pharmacol Physiol. 2015;42:510–519.
Dittrich A, Grimm D, Sahana J, et al. Key proteins involved in spheroid formation and angiogenesis in endothelial cells after long-term exposure to simulated microgravity. Cell Physiol Biochem. 2018;45:429–445.
Morbidelli L, Monici M, Marziliano N, et al. Simulated hypogravity impairs the angiogenic response of endothelium by up-regulating apoptotic signals. Biochem Biophys Res Commun. 2005;334:491–499.
Carlsson SI, Bertilaccio MT, Ballabio E, et al. Endothelial stress by gravitational unloading: effects on cell growth and cytoskeletal organization. Biochim Biophys Acta. 2003;1642:173–179.
Crawford-Young SJ. Effects of microgravity on cell cytoskeleton and embryogenesis. Int J Dev Biol. 2006;50:183–191.
Janmaleki M, Pachenari M, Seyedpour SM, et al. Impact of simulated microgravity on cytoskeleton and viscoelastic properties of endothelial cell. Sci Rep. 2016;6:32418.
Giacinto O, Pelliccia F, Minati A, et al. Cosmic radiations and the cardiovascular system: a narrative review [published online ahead of print December 28, 2022]. Cardiol Rev. doi:10.1097/CRD.0000000000000521.
doi: 10.1097/CRD.0000000000000521
Eilenberg W, Stojkovic S, Piechota-Polanczyk A, et al. Neutrophil gelatinase-associated lipocalin (NGAL) is associated with symptomatic carotid atherosclerosis and drives pro-inflammatory state in vitro. Eur J Vasc Endovasc Surg. 2016;51:623–631.
Suffee N, Hlawaty H, Meddahi-Pelle A, et al. RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans. Angiogenesis. 2012;15:727–744.
Glasauer A, Chandel NS. ROS. Curr Biol. 2013;23:R100–R102.
Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84.
Mates JM, Segura JA, Alonso FJ, et al. Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol. 2008;82:273–299.
Sugamura K, Keaney JF Jr. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 2011;51:978–992.
Lambeth JD. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic Biol Med. 2007;43:332–347.
Li Q, Youn JY, Cai H. Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension. J Hypertens. 2015;33:1128–1136.
Rochette L, Lorin J, Zeller M, et al. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets?. Pharmacol Ther. 2013;140:239–257.
Wang J, Zhang J, Bai S, et al. Simulated microgravity promotes cellular senescence via oxidant stress in rat PC12 cells. Neurochem Int. 2009;55:710–716.
Zhang R, Bai YG, Lin LJ, et al. Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats. J Appl Physiol (1985). 2009;106:251–258.
Peng L, Ran HH, Zhang Y, et al. NADPH oxidase accounts for changes in cerebrovascular redox status in hindlimb unweighting rats. Biomed Environ Sci. 2015;28:799–807.
Zhang R, Ran HH, Peng L, et al. Mitochondrial regulation of NADPH oxidase in hindlimb unweighting rat cerebral arteries. PLoS One. 2014;9:e95916.
Cazzaniga A, Locatelli L, Castiglioni S, et al. The dynamic adaptation of primary human endothelial cells to simulated microgravity. FASEB J. 2019;33:5957–5966.
Kirsch KA, Baartz FJ, Gunga HC, et al. Fluid shifts into and out of superficial tissues under microgravity and terrestrial conditions. Clin Investig. 1993;71:687–689.
Navasiolava NM, Dignat-George F, Sabatier F, et al. Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers. Am J Physiol Heart Circ Physiol. 2010;299:H248–H256.
Demiot C, Dignat-George F, Fortrat JO, et al. WISE 2005: chronic bed rest impairs microcirculatory endothelium in women. Am J Physiol Heart Circ Physiol. 2007;293:H3159–H3164.
Alfrey CP, Udden MM, Huntoon CL, et al. Destruction of newly released red blood cells in space flight. Med Sci Sports Exerc. 1996;28:S42–S44.
Hughson RL, Helm A, Durante M. Heart in space: effect of the extraterrestrial environment on the cardiovascular system. Nat Rev Cardiol. 2018;15:167–180.
Norsk P, Christensen NJ. The paradox of systemic vasodilatation and sympathetic nervous stimulation in space. Respir Physiol Neurobiol. 2009;169:S26–S29.
Prisk GK, Guy HJ, Elliott AR, et al. Pulmonary diffusing capacity, capillary blood volume, and cardiac output during sustained microgravity. J Appl Physiol (1985). 1993;75:15–26.
Arbeille P, Fomina G, Roumy J, et al. Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflights. Eur J Appl Physiol. 2001;86:157–168.
Norsk P, Asmar A, Damgaard M, et al. Fluid shifts, vasodilatation and ambulatory blood pressure reduction during long duration spaceflight. J Physiol. 2015;593:573–584.
Carrick-Ranson G, Hastings JL, Bhella PS, et al. The effect of exercise training on left ventricular relaxation and diastolic suction at rest and during orthostatic stress after bed rest. Exp Physiol. 2013;98:501–513.
Dorfman TA, Levine BD, Tillery T, et al. Cardiac atrophy in women following bed rest. J Appl Physiol (1985). 2007;103:8–16.
Summers RL, Martin DS, Meck JV, et al. Mechanism of spaceflight-induced changes in left ventricular mass. Am J Cardiol. 2005;95:1128–1130.
May C, Borowski A, Martin D, et al. Affect of microgravity on cardiac shape: comparison of pre- and in-flight data to mathematical modeling. J Am Coll Cardiol. 2014;63:A1096-A.
Abdullah SM, Hastings JL, Shibata S, et al. Abstract 18672: effects of prolonged space flight on cardiac structure and function. Circulation. 2013;128:A18672-A.
Mulvagh SL, Charles JB, Riddle JM, et al. Echocardiographic evaluation of the cardiovascular effects of short-duration spaceflight. J Clin Pharmacol. 1991;31:1024–1026.
Vernice NA, Meydan C, Afshinnekoo E, et al. Long-term spaceflight and the cardiovascular system. Precis Clin Med. 2020;3:284–291.
D’Aunno DS, Dougherty AH, DeBlock HF, et al. Effect of short- and long-duration spaceflight on QTc intervals in healthy astronauts. Am J Cardiol. 2003;91:494–497.
Baran R, Marchal S, Garcia Campos S, et al. The cardiovascular system in space: focus on in vivo and in vitro studies. Biomedicines. 2021;10:59.
Shaffer F, Ginsberg JP. An overview of heart rate variability metrics and norms. Front Public Health. 2017;5:258.
Xu D, Shoemaker JK, Blaber AP, et al. Reduced heart rate variability during sleep in long-duration spaceflight. Am J Physiol Regul Integr Comp Physiol. 2013;305:R164–R170.
Bogomolov VV, Kondratenko SN, Kovachevich IV, et al. Propranolol pharmacokinetics and hemodynamic indices in antiorthostatic hypokinesia. Aviakosm Ekolog Med. 2016;50:5–10.
Soucy KG, Lim HK, Kim JH, et al. HZE (5)(6)Fe-ion irradiation induces endothelial dysfunction in rat aorta: role of xanthine oxidase. Radiat Res. 2011;176:474–485.
LaRocca TJ, Martens CR, Seals DR. Nutrition and other lifestyle influences on arterial aging. Ageing Res Rev. 2017;39:106–119.
Boehm F, Edge R, Truscott TG, et al. A dramatic effect of oxygen on protection of human cells against gamma-radiation by lycopene. FEBS Lett. 2016;590:1086–1093.
Martens CR, Seals DR. Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing. J Physiol. 2016;594:7177–7195.
Sun H, Ling S, Zhao D, et al. Panax quinquefolium saponin attenuates cardiac remodeling induced by simulated microgravity. Phytomedicine. 2019;56:83–93.
Arbeille P, Provost R, Zuj K. Carotid and femoral artery intima-media thickness during 6 months of spaceflight. Aerosp Med Hum Perform. 2016;87:449–453.
Hughson RL, Robertson AD, Arbeille P, et al. Increased postflight carotid artery stiffness and inflight insulin resistance resulting from 6-mo spaceflight in male and female astronauts. Am J Physiol Heart Circ Physiol. 2016;310:H628–H638.
Zhang LF. Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment. Eur J Appl Physiol. 2013;113:2873–2895.
Lackner JR, DiZio P. Artificial gravity as a countermeasure in long-duration space flight. J Neurosci Res. 2000;62:169–176.
Tays GD, McGregor HR, Lee JK, et al. The effects of 30 minutes of artificial gravity on cognitive and sensorimotor performance in a spaceflight analog environment. Front Neural Circuits. 2022;16:784280.
Griffoni C, Di Molfetta S, Fantozzi L, et al. Modification of proteins secreted by endothelial cells during modeled low gravity exposure. J Cell Biochem. 2011;112:265−272.
Infanger M, Kossmehl P, Shakibaei M, et al. Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity: impact of vascular endothelial growth factor. Apoptosis. 2006;11:749−764.