Reasons for antiretroviral switching in Colombia: A retrospective cohort study.

Long-term use of antiretroviral therapy (ART) for HIV infection might lead to the necessity of switching regimens. We aimed to analyze the reasons for the ART switch, the time-to-switch of ART, and its associated factors in a Colombian cohort. We conducted a retrospective cohort in 20 HIV clinics, including participants ≥18 years old with confirmed HIV infection who underwent an ART switch from January 2017 to December 2019 with at least 6 months of follow-up. A time-to-event analysis and an exploratory Cox model were performed. 796 participants switched ART during the study period. The leading cause of ART switch was drug intolerance ( In this Colombian cohort, drug intolerance was the main cause of the ART switch, and the time-to-switch is shorter than reports from other countries. In Colombia, it is crucial to apply current recommendations for ART initiation to choose regimens with a better tolerability profile.

Déclaration de conflit d'intérêts

Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: WL declares MSD unrestricted grant. MGG and SMV declare personal fees from MSD. SLVB and CAM declare MSD grant. CBR and JU are employees of MSD, Colombia, who may own stock and/or hold stock options in Merck and Co., Inc., Kenilworth, NJ USA. EM reports grants, personal fees and other from VIIV/ GSK, personal fees and other from Merck Sharp and Dohme Corp, personal fees and other from Biotoscana gilead group. SL was MSD employee during manuscript development SVC, MJR, LAM, MM, LMR, OS, JF, CG, NF, MB, JA, DA, JAA do not declare any conflict of interest.