Comparative assessment of choroidal thickness and choroidal vascularity index in patients with restless legs syndrome.
Choroidal thickness
Choroidal vascularity index, OCT
Restless legs syndrome
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
27
04
2023
revised:
14
06
2023
accepted:
07
07
2023
medline:
8
9
2023
pubmed:
11
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
Increased sympathetic activity has been emphasized in the pathophysiology of restless legs syndrome (RLS). This study aims to evaluate the choroidal thickness (CT) and choroidal vascularity index (CVI) values of individuals with RLS. A total of 60 volunteers, 30 individuals with RLS and 30 healthy individuals, were included in the study. The central macular thickness, subfoveal CT, and the CTs 1000 μm away from the fovea in the temporal and nasal regions were measured by optical coherence tomography. Total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using the binarization method. CVI was calculated as the ratio of lumen area to total choroidal area (LA/TCA). There was no significant difference between the participants in terms of age, gender, spherical equivalent, intraocular pressure, and axial length (p>0.05). The mean LA/SA was 1.56%±0.05 in RLS group and 1.99%±0.28 in the control group. The mean CVI was 0.64%±0.02% in RLS group and 0.66%±0.03 in the control group. There was no significant difference between the groups in terms of CT, TCA and LA values. There were significant differences between the groups in SA, LA/SA and CVI values (p = 0.017, p<0.001, and p = 0.004, respectively). SA values were significantly higher in RLS group than in control group. The LA/SA and CVI values were significantly lower in RLS group than in control group. These findings suggests that there is vascular narrowing due to sympathetic overactivity in RLS patients.
Sections du résumé
BACKGROUND
BACKGROUND
Increased sympathetic activity has been emphasized in the pathophysiology of restless legs syndrome (RLS). This study aims to evaluate the choroidal thickness (CT) and choroidal vascularity index (CVI) values of individuals with RLS.
METHODS
METHODS
A total of 60 volunteers, 30 individuals with RLS and 30 healthy individuals, were included in the study. The central macular thickness, subfoveal CT, and the CTs 1000 μm away from the fovea in the temporal and nasal regions were measured by optical coherence tomography. Total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using the binarization method. CVI was calculated as the ratio of lumen area to total choroidal area (LA/TCA).
RESULTS
RESULTS
There was no significant difference between the participants in terms of age, gender, spherical equivalent, intraocular pressure, and axial length (p>0.05). The mean LA/SA was 1.56%±0.05 in RLS group and 1.99%±0.28 in the control group. The mean CVI was 0.64%±0.02% in RLS group and 0.66%±0.03 in the control group. There was no significant difference between the groups in terms of CT, TCA and LA values. There were significant differences between the groups in SA, LA/SA and CVI values (p = 0.017, p<0.001, and p = 0.004, respectively).
CONCLUSION
CONCLUSIONS
SA values were significantly higher in RLS group than in control group. The LA/SA and CVI values were significantly lower in RLS group than in control group. These findings suggests that there is vascular narrowing due to sympathetic overactivity in RLS patients.
Identifiants
pubmed: 37429457
pii: S1572-1000(23)00428-3
doi: 10.1016/j.pdpdt.2023.103701
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103701Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None of the authors have any proprietary interests or conflicts of interest related to this submission