Optical Approaches for Investigating Neuromodulation and G Protein-Coupled Receptor Signaling.
Journal
Pharmacological reviews
ISSN: 1521-0081
Titre abrégé: Pharmacol Rev
Pays: United States
ID NLM: 0421737
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
05
02
2022
revised:
06
04
2023
accepted:
01
05
2023
medline:
23
10
2023
pubmed:
11
7
2023
entrez:
10
7
2023
Statut:
ppublish
Résumé
Despite the fact that roughly 40% of all US Food and Drug Administration (FDA)-approved pharmacological therapeutics target G protein-coupled receptors (GPCRs), there remains a gap in our understanding of the physiologic and functional role of these receptors at the systems level. Although heterologous expression systems and in vitro assays have revealed a tremendous amount about GPCR signaling cascades, how these cascades interact across cell types, tissues, and organ systems remains obscure. Classic behavioral pharmacology experiments lack both the temporal and spatial resolution to resolve these long-standing issues. Over the past half century, there has been a concerted effort toward the development of optical tools for understanding GPCR signaling. From initial ligand uncaging approaches to more recent development of optogenetic techniques, these strategies have allowed researchers to probe longstanding questions in GPCR pharmacology both in vivo and in vitro. These tools have been employed across biologic systems and have allowed for interrogation of everything from specific intramolecular events to pharmacology at the systems level in a spatiotemporally specific manner. In this review, we present a historical perspective on the motivation behind and development of a variety of optical toolkits that have been generated to probe GPCR signaling. Here we highlight how these tools have been used in vivo to uncover the functional role of distinct populations of GPCRs and their signaling cascades at a systems level. SIGNIFICANCE STATEMENT: G protein-coupled receptors (GPCRs) remain one of the most targeted classes of proteins for pharmaceutical intervention, yet we still have a limited understanding of how their unique signaling cascades effect physiology and behavior at the systems level. In this review, we discuss a vast array of optical techniques that have been devised to probe GPCR signaling both in vitro and in vivo.
Identifiants
pubmed: 37429736
pii: pharmrev.122.000584
doi: 10.1124/pharmrev.122.000584
pmc: PMC10595021
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Pharmaceutical Preparations
0
Ligands
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1119-1139Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL150836
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH112355
Pays : United States
Organisme : NIDA NIH HHS
ID : F32 DA054709
Pays : United States
Organisme : NIMH NIH HHS
ID : P50 MH119467
Pays : United States
Organisme : NIDA NIH HHS
ID : R37 DA033396
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS128537
Pays : United States
Organisme : NIDA NIH HHS
ID : R61 DA051489
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033396
Pays : United States
Informations de copyright
Copyright © 2023 by The Author(s).
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