TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
Cancer
Oncogenesis
T-cell receptor excision circles (TREC)
Journal
Molecular cancer
ISSN: 1476-4598
Titre abrégé: Mol Cancer
Pays: England
ID NLM: 101147698
Informations de publication
Date de publication:
10 07 2023
10 07 2023
Historique:
received:
17
03
2023
accepted:
25
05
2023
medline:
12
7
2023
pubmed:
11
7
2023
entrez:
10
7
2023
Statut:
epublish
Résumé
The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.3%) patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Remarkably, the reintegration of TREC recurrently targeted the tumor suppressor gene, ZFP36L2, in 17/20 samples. Thus, our data identified a new and hardly detectable mechanism of gene deregulation in lymphoid cancers providing new insights in human oncogenesis.
Identifiants
pubmed: 37430263
doi: 10.1186/s12943-023-01794-y
pii: 10.1186/s12943-023-01794-y
pmc: PMC10332067
doi:
Substances chimiques
ZFP36L2 protein, human
0
Transcription Factors
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108Informations de copyright
© 2023. The Author(s).
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