Chondroitin Sulfate Supplements for Osteoarthritis: A Critical Review.
chondroitin sulfate
chondroprotection
joint health
osteoarthritis
supplementation
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Jun 2023
Jun 2023
Historique:
accepted:
09
06
2023
medline:
11
7
2023
pubmed:
11
7
2023
entrez:
11
7
2023
Statut:
epublish
Résumé
Over the years, chondroitin sulfate (CS) has been used as a slow-acting drug for the treatment of osteoarthritis, for the reduction of pain and improvement of function, and for its disease-modifying properties by limiting cartilage volume loss and joint space narrowing progression. However, there have been inconsistencies in published trials regarding clinical efficacy, with reports of a lack of significant effects compared to placebo. The therapeutic effects of chondroitin sulfate may depend on many variables, such as the source of origin, purity, and contamination with by-products. Another source of confusion may be related to the fact that CS is commonly combined with glucosamine, which makes it challenging to isolate the specific contribution of chondroitin to the therapeutic outcome. This is aggravated by the fact that CS supplements, used in many countries, are not regulated, and labels wrongly claim high levels of purity. Many of these inferior CS products may have been used in clinical trials, which may have had limited but significant results. This has led to recent recommendations to opt for higher-purity pharmacologic-grade CS for the treatment of OA. This article aims to provide an up-to-date view of the current literature regarding the biological effects and efficacy of CS and discusses the quality of available chondroitin sulfate supplements and the current direction in CS investigation. This review concludes that pharmacologic-grade CS supplements may have clinically significant benefits when properly standardized; however, high-quality evidence from properly designed clinical trials is still needed to draw definitive conclusions about clinical efficacy in osteoarthritis.
Identifiants
pubmed: 37431333
doi: 10.7759/cureus.40192
pmc: PMC10329866
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e40192Informations de copyright
Copyright © 2023, Brito et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
BMJ. 2010 Sep 16;341:c4675
pubmed: 20847017
Osteoarthritis Cartilage. 2006 Jun;14(6):519-25
pubmed: 16503173
Aging Clin Exp Res. 2021 Jan;33(1):37-47
pubmed: 32638342
Curr Rheumatol Rep. 2019 Jun 15;21(8):40
pubmed: 31203463
Osteoarthritis Cartilage. 2006 Feb;14(2):114-9
pubmed: 16242972
J Rheumatol. 2010 Mar;37(3):656-64
pubmed: 20110528
Osteoarthritis Cartilage. 1998 May;6 Suppl A:6-13
pubmed: 9743813
Anal Biochem. 2008 Mar 1;374(1):213-20
pubmed: 18054774
Rheumatol Int. 2018 Aug;38(8):1413-1428
pubmed: 29947998
Osteoarthritis Cartilage. 2004 Apr;12(4):269-76
pubmed: 15023378
Drug Deliv. 2022 Dec;29(1):652-663
pubmed: 35188017
Arthritis Rheum. 2005 Mar;52(3):779-86
pubmed: 15751094
Adv Ther. 2019 May;36(5):1085-1099
pubmed: 30879253
Arthritis Rheum. 2009 Feb;60(2):524-33
pubmed: 19180484
Arthritis Rheum. 1998 Feb;41(2):284-9
pubmed: 9485086
Carbohydr Polym. 2019 Oct 15;222:114984
pubmed: 31320062
IUBMB Life. 2002 Oct;54(4):177-86
pubmed: 12512856
Ann Rheum Dis. 2007 May;66(5):639-45
pubmed: 17204566
Ann Rehabil Med. 2011 Oct;35(5):701-9
pubmed: 22506194
Clin Orthop Relat Res. 2001 Oct;(391 Suppl):S108-15
pubmed: 11603695
Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S32-40
pubmed: 20399899
Acta Biomater. 2022 Oct 1;151:512-527
pubmed: 35964941
Drugs Aging. 2007;24(7):573-80
pubmed: 17658908
J Pharm Sci. 2007 Dec;96(12):3168-80
pubmed: 17630645
Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii75-82
pubmed: 19022820
Exp Biol Med (Maywood). 2005 Apr;230(4):255-62
pubmed: 15792947
Front Pharmacol. 2021 Jul 09;12:655101
pubmed: 34305585
Drugs Aging. 2019 Apr;36(Suppl 1):65-99
pubmed: 31073924
Lancet. 2012 Dec 15;380(9859):2197-223
pubmed: 23245608
Arzneimittelforschung. 2000 Feb;50(2):148-53
pubmed: 10719618
Arthritis Res Ther. 2016 Nov 3;18(1):256
pubmed: 27809891
Arthritis Res Ther. 2007;9(6):R117
pubmed: 17996099
J Pharm Pharmacol. 2009 Oct;61(10):1271-80
pubmed: 19814858
Basic Clin Pharmacol Toxicol. 2008 Jan;102(1):59-65
pubmed: 17983423
Arthritis Res Ther. 2007;9(4):R74
pubmed: 17672891
Exp Mol Med. 2005 Oct 31;37(5):476-81
pubmed: 16264272
Clin Exp Rheumatol. 2002 Sep-Oct;20(5):669-76
pubmed: 12412198
Appl Microbiol Biotechnol. 2012 Apr;94(2):295-305
pubmed: 22391966
Arthritis Rheum. 1999 Jul;42(7):1528-37
pubmed: 10403282
Adv Pharmacol. 2006;53:417-31
pubmed: 17239778
Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31
pubmed: 20399895
Curr Drug Targets. 2007 Feb;8(2):305-13
pubmed: 17305508
Cochrane Database Syst Rev. 2015 Jan 28;1:CD005614
pubmed: 25629804
Inflammopharmacology. 2013 Dec;21(6):407-12
pubmed: 23644893
Dent Mater J. 2010 Aug;29(4):403-10
pubmed: 20610874
Ann Rheum Dis. 2011 Jun;70(6):982-9
pubmed: 21367761
Osteoarthritis Cartilage. 1998 May;6(3):196-204
pubmed: 9682786
J Rheumatol. 2000 Apr;27(4):1005-19
pubmed: 10782830
Clin Chim Acta. 1995 May 15;236(2):195-204
pubmed: 7554286
Bull World Health Organ. 2003;81(9):646-56
pubmed: 14710506
Carbohydr Polym. 2015 Dec 10;134:300-8
pubmed: 26428128
Arthritis Rheum. 2008 Oct;58(10):3183-91
pubmed: 18821708
J Nutr Health Aging. 2022;26(3):307-313
pubmed: 35297475
Am J Pathol. 2007 Sep;171(3):938-46
pubmed: 17640966
Am J Vet Res. 2005 Nov;66(11):1870-6
pubmed: 16334942
Mater Sci Eng C Mater Biol Appl. 2021 Aug;127:112234
pubmed: 34225875
Mol Cell Proteomics. 2012 Jun;11(6):M111.013417
pubmed: 22203690
Rheumatol Int. 2010 Jan;30(3):357-63
pubmed: 19544061
Biol Pharm Bull. 2018 Feb 1;41(2):163-171
pubmed: 29176264
Arthritis Res Ther. 2012 Mar 12;14(2):R58
pubmed: 22409996
Eur Rev Med Pharmacol Sci. 2021 Sep;25(17):5402-5411
pubmed: 34533814
N Engl J Med. 2006 Feb 23;354(8):795-808
pubmed: 16495392
J Spec Oper Med. 2019 Spring;19(1):113-124
pubmed: 30859538
Int J Tissue React. 1992;14(5):231-41
pubmed: 1300309
Aging Clin Exp Res. 2018 Feb;30(2):111-117
pubmed: 29177637