Clinical validation of the parent-report Toronto Obsessive-Compulsive Scale (TOCS): A pediatric open-source rating scale.
ROC analysis
cross‐disorder phenotyping
neurodevelopmental disorders
obsessive–compulsive disorder
obsessive–compulsive traits
scale development
Journal
JCPP advances
ISSN: 2692-9384
Titre abrégé: JCPP Adv
Pays: United States
ID NLM: 9918250414706676
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
28
10
2021
accepted:
05
11
2021
medline:
3
12
2021
pubmed:
3
12
2021
entrez:
11
7
2023
Statut:
epublish
Résumé
There is a need to develop a multipurpose obsessive-compulsive disorder (OCD) measure that is useful for cross disorder research and as a reliable clinical rating scale. The current study examined the psychometric properties and established clinical cutoffs for the parent-report version of the Toronto Obsessive-Compulsive Scale (TOCS), a 21-item rating scale of obsessive-compulsive traits. Participants ranged in age from 6 to 21 years old and had a primary diagnosis of OCD ( The psychometric properties of the TOCS were confirmed. ROC analyses across TOCS scoring approaches in the discovery sample indicated excellent diagnostic discrimination (AUC ≥0.95, sensitivity 77%-92%, specificity 92%-98%). Established cutoffs, when applied in the independent validation sample of OCD cases and controls, showed an overall classification accuracy of 85%-90%. The TOCS total score and symptom count showed good discrimination of OCD from ADHD (AUC ≥0.86) and ASD (AUC ≥0.81). The OCD group scored significantly higher on all TOCS dimensions (except Hoarding) than the ADHD and ASD groups. The TOCS is a reliable and valid rating scale with strong sensitivity and specificity in discriminating OCD cases from controls, as well as from ASD and ADHD. It is a quantitative OCD measure with important clinical and research applications, with particular relevance for cross disorder phenotyping and population-based studies.
Sections du résumé
Background
UNASSIGNED
There is a need to develop a multipurpose obsessive-compulsive disorder (OCD) measure that is useful for cross disorder research and as a reliable clinical rating scale. The current study examined the psychometric properties and established clinical cutoffs for the parent-report version of the Toronto Obsessive-Compulsive Scale (TOCS), a 21-item rating scale of obsessive-compulsive traits.
Method
UNASSIGNED
Participants ranged in age from 6 to 21 years old and had a primary diagnosis of OCD (
Results
UNASSIGNED
The psychometric properties of the TOCS were confirmed. ROC analyses across TOCS scoring approaches in the discovery sample indicated excellent diagnostic discrimination (AUC ≥0.95, sensitivity 77%-92%, specificity 92%-98%). Established cutoffs, when applied in the independent validation sample of OCD cases and controls, showed an overall classification accuracy of 85%-90%. The TOCS total score and symptom count showed good discrimination of OCD from ADHD (AUC ≥0.86) and ASD (AUC ≥0.81). The OCD group scored significantly higher on all TOCS dimensions (except Hoarding) than the ADHD and ASD groups.
Conclusion
UNASSIGNED
The TOCS is a reliable and valid rating scale with strong sensitivity and specificity in discriminating OCD cases from controls, as well as from ASD and ADHD. It is a quantitative OCD measure with important clinical and research applications, with particular relevance for cross disorder phenotyping and population-based studies.
Identifiants
pubmed: 37431399
doi: 10.1002/jcv2.12056
pii: JCV212056
pmc: PMC10242913
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12056Informations de copyright
© 2021 The Authors. JCPP Advances published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.
Déclaration de conflit d'intérêts
The authors have declared that they have no competing or potential conflicts of interest.
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