Rhodium(III)-Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy.

Humans Female Rhodium / pharmacology Antineoplastic Agents / pharmacology Apoptosis Cell Proliferation Breast Neoplasms Autophagy Cell Line, Tumor Coordination Complexes / pharmacology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
27 07 2023
Historique:
medline: 28 7 2023
pubmed: 11 7 2023
entrez: 11 7 2023
Statut: ppublish

Résumé

As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and antimetastatic activities, herein, we reported the syntheses of 11 new rhodium(III)-picolinamide complexes and the exploration of their potential anticancer activities. These Rh(III) complexes showed high antiproliferative activity against the tested cancer cell lines in vitro. The mechanism study indicated that

Identifiants

DOI: 10.1021/acs.jmedchem.3c00318 PMID: 37432720
pubmed: 37432720
doi: 10.1021/acs.jmedchem.3c00318
doi:

Substances chimiques

Rhodium DMK383DSAC
picolinamide I3550CCL59
Antineoplastic Agents 0
Coordination Complexes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9592-9606

Auteurs

Yun-Qiong Gu (YQ)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
School of Environment and Life Science, Nanning Normal University, Nanning 530001, P. R China.

Kun Yang (K)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Qi-Yuan Yang (QY)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Huan-Qing Li (HQ)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Mei-Qi Hu (MQ)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Meng-Xue Ma (MX)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Nan-Feng Chen (NF)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Yang-Han Liu (YH)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Hong Liang (H)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.

Zhen-Feng Chen (ZF)

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Centre for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
ORCID: 0000-0002-6548-6131

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Rhodium › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Rhodium(III)-Picolinamide Complexes Act as...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Rhodium(III)-Picolinamide Complexes Act as...