Characterizing metal-biomolecule interactions by mass spectrometry.
disease diagnostics
metal binding
metallomics
metalloproteome
proteomics
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
15
02
2023
revised:
13
06
2023
accepted:
14
06
2023
medline:
14
8
2023
pubmed:
12
7
2023
entrez:
11
7
2023
Statut:
ppublish
Résumé
Metal micronutrients are essential for life and exist in a delicate balance to maintain an organism's health. The labile nature of metal-biomolecule interactions clouds the understanding of metal binders and metal-mediated conformational changes that are influential to health and disease. Mass spectrometry (MS)-based methods and technologies have been developed to better understand metal micronutrient dynamics in the intra- and extracellular environment. In this review, we describe the challenges associated with studying labile metals in human biology and highlight MS-based methods for the discovery and study of metal-biomolecule interactions.
Identifiants
pubmed: 37433704
pii: S0968-0004(23)00145-7
doi: 10.1016/j.tibs.2023.06.006
pii:
doi:
Substances chimiques
Metals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
815-825Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.