One-year longitudinal study of the stratum corneum proteome of retinol and all-trans-retinoic acid treated human skin: an orchestrated molecular event.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 07 2023
11 07 2023
Historique:
received:
09
03
2023
accepted:
27
06
2023
medline:
13
7
2023
pubmed:
12
7
2023
entrez:
11
7
2023
Statut:
epublish
Résumé
Topically applied all-trans-retinoic acid (RA) is a gold-standard anti-aging molecule used in dermatology. As its cosmetic counterpart used in anti-aging, Retinol (ROL) is also a known metabolic precursor of RA. Despite this metabolic link, they haven't been compared exhaustively in vivo at a mechanistic level. Therefore, to highlight the effect of a topical application of both molecules on in vivo skin, we undertook a longitudinal 1-year study and performed an untargeted proteomic analysis to get a more holistic view on the underlying biological mechanisms of action. The generation of the temporal proteomics signatures of retinol and all-trans-retinoic acid reveals the impact of these molecules on biological functions related to the aging of skin. New biological functions impacted by retinoids were discovered: glycan metabolism and protein biosynthesis. In addition, the temporal analysis reveals highest modulations at early time points while the physical measures, such as epidermal thickening, was mostly observed at the latest time point, demonstrating a strong time lapse between molecular and morphological impacts. Finally, these global temporal signatures could be used to identify new cosmetic compounds of interest.
Identifiants
pubmed: 37433822
doi: 10.1038/s41598-023-37750-5
pii: 10.1038/s41598-023-37750-5
pmc: PMC10336116
doi:
Substances chimiques
Vitamin A
11103-57-4
Proteome
0
Tretinoin
5688UTC01R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11196Informations de copyright
© 2023. The Author(s).
Références
Cells. 2020 Jul 01;9(7):
pubmed: 32630207
Bioinformatics. 2009 Jan 15;25(2):288-9
pubmed: 19033274
Aging (Albany NY). 2020 Jun 29;12(13):13529-13554
pubmed: 32602849
J Invest Dermatol. 1990 Nov;95(5):510-5
pubmed: 1700022
J Biol Chem. 2003 Oct 24;278(43):41589-92
pubmed: 12963727
Skin Res Technol. 2020 Nov;26(6):794-803
pubmed: 32713074
FASEB J. 2010 Feb;24(2):627-36
pubmed: 19812372
Clin Geriatr Med. 2013 May;29(2):xi-xx
pubmed: 23571044
BMC Genomics. 2017 Feb 15;18(1):169
pubmed: 28201987
Skin Pharmacol Physiol. 2009;22(4):200-9
pubmed: 19648781
J Gerontol A Biol Sci Med Sci. 2004 May;59(5):411-5
pubmed: 15123749
PLoS One. 2015 May 07;10(5):e0125934
pubmed: 25950531
Arch Biochem Biophys. 2000 Jan 1;373(1):91-101
pubmed: 10620327
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Cell Cycle. 2013 Jun 15;12(12):1922-7
pubmed: 23673343
Skin Res Technol. 2011 Feb;17(1):119-28
pubmed: 21226879
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
J Invest Dermatol. 2000 Mar;114(3):487-93
pubmed: 10692107
RSC Adv. 2018 Apr 16;8(25):14048-14055
pubmed: 35539303
Adv Wound Care (New Rochelle). 2020 Mar 1;9(3):127-143
pubmed: 31993254
Arch Dermatol. 2007 May;143(5):606-12
pubmed: 17515510
J Biol Chem. 1991 Sep 15;266(26):17662-6
pubmed: 1654334
Cell. 2007 May 18;129(4):649-51
pubmed: 17512397
Dermatoendocrinol. 2011 Jul;3(3):136-40
pubmed: 22110773
J Invest Dermatol. 1992 Mar;98(3):343-50
pubmed: 1372028
Biofactors. 2005;25(1-4):179-85
pubmed: 16873944
J Drugs Dermatol. 2013 Jun 1;12(6):638-42
pubmed: 23839179
J Am Acad Dermatol. 1998 Aug;39(2 Pt 3):S55-61
pubmed: 9703125
J Invest Dermatol. 2023 Mar;143(3):492-494.e10
pubmed: 36055400
Dermatol Nurs. 2006 Jun;18(3):265-6
pubmed: 16856682
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Cutis. 2001 Aug;68(2):135-42
pubmed: 11534915