Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
11 Jul 2023
Historique:
received: 12 02 2023
accepted: 16 06 2023
revised: 31 05 2023
medline: 12 7 2023
pubmed: 12 7 2023
entrez: 11 7 2023
Statut: aheadofprint

Résumé

Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores. In this study, we developed a polygenic score for lithium treatment response (Li

Identifiants

pubmed: 37433967
doi: 10.1038/s41380-023-02149-1
pii: 10.1038/s41380-023-02149-1
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : Emerging Leadership Investigator Grant 2021 - 2008000

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2023. The Author(s).

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Auteurs

Azmeraw T Amare (AT)

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia. azmeraw.amare@adelaide.edu.au.

Anbupalam Thalamuthu (A)

Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, UNSW Medicine & Health, University of New South Wales, Sydney, Australia.

Klaus Oliver Schubert (KO)

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.
Northern Adelaide Local Health Network, Mental Health Services, Adelaide, SA, Australia.

Janice M Fullerton (JM)

Neuroscience Research Australia, Sydney, NSW, Australia.
School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Muktar Ahmed (M)

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Simon Hartmann (S)

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Sergi Papiol (S)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.

Urs Heilbronner (U)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Franziska Degenhardt (F)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, LVR Klinikum Essen, University of Duisburg-Essen, Rheinische Kliniken, Essen, Germany.

Fasil Tekola-Ayele (F)

Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Liping Hou (L)

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

Yi-Hsiang Hsu (YH)

HSL Institute for Aging Research, Harvard Medical School, Boston, MA, USA.
Program for Quantitative Genomics, Harvard School of Public Health, Boston, MA, USA.

Tatyana Shekhtman (T)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Mazda Adli (M)

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.

Nirmala Akula (N)

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

Kazufumi Akiyama (K)

Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.

Raffaella Ardau (R)

Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.

Bárbara Arias (B)

Unitat de Zoologia i Antropologia Biològica (Dpt. Biologia Evolutiva, Ecologia i Ciències Ambientals), Facultat de Biologia and Institut de Biomedicina (IBUB), University of Barcelona, CIBERSAM, Barcelona, Spain.

Jean-Michel Aubry (JM)

Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.

Roland Hasler (R)

Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.

Hélène Richard-Lepouriel (H)

Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.

Nader Perroud (N)

Department of Psychiatry, Mood Disorders Unit, HUG - Geneva University Hospitals, Geneva, Switzerland.

Lena Backlund (L)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Abesh Kumar Bhattacharjee (AK)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Frank Bellivier (F)

INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.

Antonio Benabarre (A)

Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Susanne Bengesser (S)

Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.

Joanna M Biernacka (JM)

Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Armin Birner (A)

Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.

Cynthia Marie-Claire (C)

INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.
Université Paris Cité, Inserm, Optimisation Thérapeutique en Neuropsychopharmacologie, F-75006, Paris, France.

Pablo Cervantes (P)

The Neuromodulation Unit, McGill University Health Centre, Montreal, Canada.

Hsi-Chung Chen (HC)

Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.

Caterina Chillotti (C)

Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.

Sven Cichon (S)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.

Cristiana Cruceanu (C)

Douglas Mental Health University Institute, McGill University, Montreal, Canada.

Piotr M Czerski (PM)

Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.

Nina Dalkner (N)

Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.

Maria Del Zompo (M)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

J Raymond DePaulo (JR)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Bruno Étain (B)

INSERM UMR-S 1144, Université Paris Cité, Département de Psychiatrie et de Médecine Addictologique, AP-HP, Groupe Hospitalier Saint-Louis-Lariboisière-F.Widal, Paris, France.

Stephane Jamain (S)

Inserm U955, Translational Psychiatry laboratory, Fondation FondaMental, Créteil, France.

Peter Falkai (P)

Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Max Planck Institute of Psychiatry, Munich, Germany.

Andreas J Forstner (AJ)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Institute of Neuroscience and Medicine (INM-1), Research Center Jülich, Jülich, Germany.

Louise Frisen (L)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Mark A Frye (MA)

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Sébastien Gard (S)

Pôle de Psychiatrie Générale Universitaire, Hôpital Charles Perrens, Bordeaux, France.

Julie S Garnham (JS)

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Fernando S Goes (FS)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Maria Grigoroiu-Serbanescu (M)

Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.

Andreas J Fallgatter (AJ)

University Department of Psychiatry and Psychotherapy Tuebingen, University of Tübingen, Tuebingen, Germany.

Sophia Stegmaier (S)

Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany.

Thomas Ethofer (T)

Department of General Psychiatry, University of Tuebingen, Tuebingen, Germany.
Department of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany.

Silvia Biere (S)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.

Kristiyana Petrova (K)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.

Ceylan Schuster (C)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.

Kristina Adorjan (K)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.

Monika Budde (M)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Maria Heilbronner (M)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Janos L Kalman (JL)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.

Mojtaba Oraki Kohshour (MO)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Daniela Reich-Erkelenz (D)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Sabrina K Schaupp (SK)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Eva C Schulte (EC)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.

Fanny Senner (F)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.

Thomas Vogl (T)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Ion-George Anghelescu (IG)

Department of Psychiatry and Psychotherapy, Mental Health Institute Berlin, Berlin, Germany.

Volker Arolt (V)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Udo Dannlowski (U)

Institute for Translational Psychiatry, University of Münster, Münster, Germany.

Detlef Dietrich (D)

AMEOS Clinical Center Hildesheim, Hildesheim, Germany.
Center for Systems Neuroscience (ZSN), Hannover, Germany.

Christian Figge (C)

Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, 26160, Germany.

Markus Jäger (M)

Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.

Fabian U Lang (FU)

Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.

Georg Juckel (G)

Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.

Carsten Konrad (C)

Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.

Jens Reimer (J)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Department of Psychiatry, Health North Hospital Group, Bremen, Germany.

Max Schmauß (M)

Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.

Andrea Schmitt (A)

Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany.
Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil.

Carsten Spitzer (C)

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Rostock, Rostock, Germany.

Martin von Hagen (M)

Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.

Jens Wiltfang (J)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.

Jörg Zimmermann (J)

Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.

Till F M Andlauer (TFM)

Department of Neurology, University Hospital rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

Andre Fischer (A)

German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.

Felix Bermpohl (F)

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.

Philipp Ritter (P)

Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Silke Matura (S)

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Frankfurt, Goethe University, Frankfurt, Germany.

Anna Gryaznova (A)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.

Irina Falkenberg (I)

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.

Cüneyt Yildiz (C)

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.

Tilo Kircher (T)

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.

Julia Schmidt (J)

Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.

Marius Koch (M)

Institute for Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.

Kathrin Gade (K)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Sarah Trost (S)

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Ida S Haussleiter (IS)

Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.

Martin Lambert (M)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Anja C Rohenkohl (AC)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Vivien Kraft (V)

Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Paul Grof (P)

Mood Disorders Center of Ottawa, Ontario, Canada.

Ryota Hashimoto (R)

Department of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8553, Japan.

Joanna Hauser (J)

Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.

Stefan Herms (S)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Per Hoffmann (P)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

Esther Jiménez (E)

Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Jean-Pierre Kahn (JP)

Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.

Layla Kassem (L)

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

Po-Hsiu Kuo (PH)

Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Tadafumi Kato (T)

Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.

John Kelsoe (J)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Sarah Kittel-Schneider (S)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Würzburg, Wurzburg, Germany.

Ewa Ferensztajn-Rochowiak (E)

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Barbara König (B)

Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.

Ichiro Kusumi (I)

Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Gonzalo Laje (G)

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

Mikael Landén (M)

Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Catharina Lavebratt (C)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Marion Leboyer (M)

Inserm U955, Translational Psychiatry laboratory, Université Paris-Est-Créteil, Department of Psychiatry and Addictology of Mondor University Hospital, AP-HP, Fondation FondaMental, Créteil, France.

Susan G Leckband (SG)

Office of Mental Health, VA San Diego Healthcare System, San Diego, CA, USA.

Alfonso Tortorella (A)

Department of Psychiatry, University of Perugia, Perugia, Italy.

Mirko Manchia (M)

Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

Lina Martinsson (L)

Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.

Michael J McCarthy (MJ)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.

Susan McElroy (S)

Department of Psychiatry, Lindner Center of Hope / University of Cincinnati, Mason, OH, USA.

Francesc Colom (F)

Mental Health Research Group, IMIM-Hospital del Mar, Barcelona, Catalonia, Spain.
Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.

Vincent Millischer (V)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Marina Mitjans (M)

Department of Genetics, Microbiology and Statistics, Faculty of Biology, University of Barcelona, Barcelona, Spain.
Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain.
Centro de Investigación Biomédica en Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.

Francis M Mondimore (FM)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Palmiero Monteleone (P)

Neurosciences Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Caroline M Nievergelt (CM)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Markus M Nöthen (MM)

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.

Tomas Novák (T)

National Institute of Mental Health, Klecany, Czech Republic.

Claire O'Donovan (C)

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Norio Ozaki (N)

Department of Psychiatry & Department of Child and Adolescent Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Andrea Pfennig (A)

Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Claudia Pisanu (C)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

James B Potash (JB)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Andreas Reif (A)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.

Eva Reininghaus (E)

Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for bipolar affective disorder, Medical University of Graz, Graz, Austria.

Guy A Rouleau (GA)

Montreal Neurological Institute and Hospital, McGill University, Montreal, Canada.

Janusz K Rybakowski (JK)

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Martin Schalling (M)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Peter R Schofield (PR)

Neuroscience Research Australia, Sydney, NSW, Australia.
School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Barbara W Schweizer (BW)

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.

Giovanni Severino (G)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Paul D Shilling (PD)

Department of Psychiatry, University of California San Diego, San Diego, CA, USA.

Katzutaka Shimoda (K)

Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.

Christian Simhandl (C)

Bipolar Center Wiener Neustadt, Sigmund Freud University, Medical Faculty, Vienna, Austria.

Claire M Slaney (CM)

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Alessio Squassina (A)

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Thomas Stamm (T)

Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
Department of Clinical Psychiatry and Psychotherapy, Brandenburg Medical School, Brandenburg, Germany.

Pavla Stopkova (P)

National Institute of Mental Health, Klecany, Czech Republic.

Mario Maj (M)

Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Gustavo Turecki (G)

Douglas Mental Health University Institute, McGill University, Montreal, Canada.

Eduard Vieta (E)

Bipolar and Depressive Disorders Program,, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Julia Veeh (J)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.

Stephanie H Witt (SH)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Adam Wright (A)

School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.

Peter P Zandi (PP)

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Philip B Mitchell (PB)

School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.

Michael Bauer (M)

Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.

Martin Alda (M)

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
National Institute of Mental Health, Klecany, Czech Republic.

Marcella Rietschel (M)

Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Francis J McMahon (FJ)

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.

Thomas G Schulze (TG)

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Norton College of Medicine, Syracuse, NY, USA.

Scott R Clark (SR)

Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia.

Bernhard T Baune (BT)

Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.
Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, VIC, Australia.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia.

Classifications MeSH