Ectopic insulinoma: a systematic review.

Adult Aged Female Humans Male Middle Aged Gallium Radioisotopes Hypoglycemia Insulinoma / diagnostic imaging Pancreatic Neoplasms / diagnostic imaging Positron Emission Tomography Computed Tomography Somatostatin
Aberrant insulinoma Ectopic insulinoma Extra-pancreatic insulinoma Insulinoma

Journal

Reviews in endocrine & metabolic disorders
ISSN: 1573-2606
Titre abrégé: Rev Endocr Metab Disord
Pays: Germany
ID NLM: 100940588

Informations de publication

Date de publication:
12 2023
Historique:
accepted: 07 07 2023
medline: 6 12 2023
pubmed: 12 7 2023
entrez: 11 7 2023
Statut: ppublish

Résumé

Knowledge of ectopic insulinomas comes from single cases. We performed a systematic review through PubMed, Web of Science, Embase, eLibrary and ScienceDirect of all cases reported in the last four decades. We also describe one unreported patient. From 28 patients with ectopic insulinoma, 78.6% were female and mean age was 55.7 ± 19.2 years. Hypoglycaemia was the first symptom in 85.7% while 14.3% complained of abdominal pain or genital symptoms. Median tumour diameter was 27.5 [15-52.5] mm and it was localised by CT (73.1%), MRI (88.9%), [

Identifiants

DOI: 10.1007/s11154-023-09824-2 PMID: 37434098
pubmed: 37434098
doi: 10.1007/s11154-023-09824-2
pii: 10.1007/s11154-023-09824-2
doi:

Substances chimiques

Gallium Radioisotopes 0
Somatostatin 51110-01-1

Types de publication

Journal Article Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1135-1146

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

Shah P, Rahman SA, Demirbilek H, Güemes M, Hussain K. Hyperinsulinaemic hypoglycaemia in children and adults. Lancet Diabetes Endocrinol. 2017;5:729–42. https://doi.org/10.1016/S2213-8587(16)30323-0 .
doi: 10.1016/S2213-8587(16)30323-0 pubmed: 27915035
Douillard C, Jannin A, Vantyghem MC. Rare causes of hypoglycemia in adults. Ann Endocrinol (Paris). 2020;81:110–7. https://doi.org/10.1016/j.ando.2020.04.003 .
doi: 10.1016/j.ando.2020.04.003 pubmed: 32409005
Iglesias P, Díez JJ. Management of endocrine disease: a clinical update on tumor-induced hypoglycemia. Eur J Endocrinol. 2014;170:R147–57. https://doi.org/10.1530/EJE-13-1012 .
doi: 10.1530/EJE-13-1012 pubmed: 24459236
de Groot JW, Rikhof B, van Doorn J, Bilo HJ, Alleman MA, Honkoop AH, et al. Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases. Endocr Relat Cancer. 2007;14:979–93. https://doi.org/10.1677/ERC-07-0161 .
doi: 10.1677/ERC-07-0161 pubmed: 18045950
Maggio I, Mollica V, Brighi N, Lamberti G, Manuzzi L, Ricci AD, et al. The functioning side of the pancreas: a review on insulinomas. J Endocrinol Invest. 2020;43:139–48. https://doi.org/10.1007/s40618-019-01091-w .
doi: 10.1007/s40618-019-01091-w pubmed: 31368049
Kim DU, Lubner MG, Mellnick VM, Joshi G, Pickhardt PJ. Heterotopic pancreatic rests: imaging features, complications, and unifying concepts. Abdom Radiol (NY). 2017;42:216–25. https://doi.org/10.1007/s00261-016-0874-9 .
doi: 10.1007/s00261-016-0874-9 pubmed: 27544356
Rezvani M, Menias C, Sandrasegaran K, Olpin JD, Elsayes KM, Shaaban AM. Heterotopic pancreas: histopathologic features, imaging findings, and complications. Radiographics. 2017;37:484–99. https://doi.org/10.1148/rg.2017160091 .
doi: 10.1148/rg.2017160091 pubmed: 28287935
Yan ML, Wang YD, Tian YF, Lin Y. Adenocarcinoma arising from intrahepatic heterotopic pancreas: a case report and literature review. World J Gastroenterol. 2012;18:2881–4. https://doi.org/10.3748/wjg.v18.i22.2881 .
doi: 10.3748/wjg.v18.i22.2881 pubmed: 22719201 pmcid: 3374996
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71 .
doi: 10.1136/bmj.n71 pubmed: 33782057 pmcid: 8005924
Lloyd RV, Osamura RY, Kloppel G, Rosai J. WHO classification of Tumours of Endocrine Organs. 4th ed. Lyon: IARC Press; 2018.
Walker MP, Shenoy V, Metz DC, Stanley CA, Fraker D, Chandrasekhara V, et al. Case presentation of 8-year follow up of recurrent malignant duodenal insulinoma and lymph node metastases and literature review of malignant Insulinoma management. BMC Endocr Disord. 2022;22:310. https://doi.org/10.1186/s12902-022-01219-9 .
doi: 10.1186/s12902-022-01219-9 pubmed: 36494838 pmcid: 9733155
Zhang X, Jia H, Li F, Fang C, Zhen J, He Q, et al. Ectopic insulinoma diagnosed by 68Ga-Exendin-4 PET/CT: a case report and review of literature. Med (Baltim). 2021;100:e25076. https://doi.org/10.1097/MD.0000000000025076 .
doi: 10.1097/MD.0000000000025076
Wang M, Vasey Q, Varikatt W, Mclean M. Ectopic insulin secretion by a large-cell neuroendocrine carcinoma of the cervix. Clin Case Rep. 2020;9:482–6. https://doi.org/10.1002/ccr3.3562 .
doi: 10.1002/ccr3.3562 pubmed: 33505694 pmcid: 7813122
Kriger A, Berelavichus S, Gorin D, Galkin G, Yukina M, Ilovayskaya I, et al. Successful surgical treatment of a patient with primary insulinoma of the liver. J Surg Case Rep. 2020;2020:rjaa519. https://doi.org/10.1093/jscr/rjaa519 .
doi: 10.1093/jscr/rjaa519 pubmed: 33391648 pmcid: 7769218
Garg R, Memon S, Patil V, Bandgar T. Extrapancreatic insulinoma. World J Nucl Med. 2020;19:162–4. https://doi.org/10.4103/wjnm.WJNM_41_19 .
doi: 10.4103/wjnm.WJNM_41_19 pubmed: 32939209 pmcid: 7478312
Sun M, Luo Y, You Y, Han X, Zhao Y, Han X, et al. Ectopic insulinoma: case report. BMC Surg. 2019;19:197. https://doi.org/10.1186/s12893-019-0661-y .
doi: 10.1186/s12893-019-0661-y pubmed: 31852474 pmcid: 6921582
Liu Q, Duan J, Zheng Y, Luo J, Cai X, Tan H. Rare malignant insulinoma with multiple liver metastases derived from ectopic pancreas: 3-year follow-up and literature review. Onco Targets Ther. 2018;11:1813–9. https://doi.org/10.2147/OTT.S154991 .
doi: 10.2147/OTT.S154991 pubmed: 29662318 pmcid: 5892612
Li TN, Liu Z, Zhang Y, Wang F. Ectopic insulinomas in the pelvis secondary to rectum neuroendocrine tumour. BMJ Case Rep. 2018;2018:bcr2018224281. https://doi.org/10.1136/bcr-2018-224281 .
doi: 10.1136/bcr-2018-224281 pubmed: 29960958 pmcid: 6040560
Mossman AK, Pattison DA, Hicks RJ, Hamblin PS, Yates CJ. Localisation of occult extra-pancreatic insulinoma using glucagon-like peptide-1 receptor molecular imaging. Intern Med J. 2018;48:97–8.
doi: 10.1111/imj.13664 pubmed: 29314520
Lombardi M, Battezzati MA, Grosso F, Muni A, Volante M, Ansaldi E. Appendix insulin secreting neuroendocrine tumor in a diabetic patient: a challenging diagnosis. J Syst Integr Neurosci. 2015. https://doi.org/10.15761/JSIN.1000128 .
doi: 10.15761/JSIN.1000128
Battocchio M, Zatelli MC, Chiarelli S, Trento M, Ambrosio MR, Pasquali C, et al. Ovarian tumors secreting insulin. Endocrine. 2015;49:611–9. https://doi.org/10.1007/s12020-015-0605-y .
doi: 10.1007/s12020-015-0605-y pubmed: 25896552
Liu J, Zhang CW, Hong DF, Wu J, Yang HG, Chen Y, et al. Laparoscope resection of retroperitoneal ectopic insulinoma: a rare case. World J Gastroenterol. 2015;21:4413–8. https://doi.org/10.3748/wjg.v21.i14.4413 .
doi: 10.3748/wjg.v21.i14.4413 pubmed: 25892896 pmcid: 4394107
Ramkumar S, Dhingra A, Jyotsna V, Ganie MA, Das CJ, Seth A, et al. Ectopic insulin secreting neuroendocrine tumor of kidney with recurrent hypoglycemia: a diagnostic dilemma. BMC Endocr Disord. 2014;14:36. https://doi.org/10.1186/1472-6823-14-36 .
doi: 10.1186/1472-6823-14-36 pubmed: 24741994 pmcid: 4046058
La Rosa S, Pariani D, Calandra C, Marando A, Sessa F, Cortese F, et al. Ectopic duodenal insulinoma: a very rare and challenging tumor type. Description of a case and review of the literature. Endocr Pathol. 2013;24:213–9. https://doi.org/10.1007/s12022-013-9262-y .
doi: 10.1007/s12022-013-9262-y pubmed: 24006218
Xian-Ling W, Yi-Ming M, Jing-Tao D, Wen-Wen Z, Zhao-Hui L, Rong L, et al. Successful laparoscope resection of ectopic insulinoma in duodenohepatic ligament. Am J Med Sci. 2011;341:420–2. https://doi.org/10.1097/MAJ.0b013e31820b8a67 .
doi: 10.1097/MAJ.0b013e31820b8a67 pubmed: 21358311
Christ E, Wild D, Forrer F, Brändle M, Sahli R, Clerici T, et al. Glucagon-like peptide-1 receptor imaging for localization of insulinomas. J Clin Endocrinol Metab. 2009;94:4398–405. https://doi.org/10.1210/jc.2009-1082 .
doi: 10.1210/jc.2009-1082 pubmed: 19820010
Cárdenas CM, Domínguez I, Campuzano M, Bezaury P, Iñiguez-Rodríguez M, Gamboa-Domínguez A, et al. Malignant insulinoma arising from intrasplenic heterotopic pancreas. JOP. 2009;10:321–3.
pubmed: 19454827
Morken NH, Majak B, Kahn JA. Insulin producing primary ovarian carcinoid tumor. Acta Obstet Gynecol Scand. 2007;86:500–1. https://doi.org/10.1080/00016340600613477 .
doi: 10.1080/00016340600613477 pubmed: 17486477
Hennings J, Garske U, Botling J, Hellman P. Malignant insulinoma in ectopic pancreatic tissue. Dig Surg. 2005;22:377–9. https://doi.org/10.1159/000090998 .
doi: 10.1159/000090998 pubmed: 16432300
Seckl MJ, Mulholland PJ, Bishop AE, Teale JD, Hales CN, Glaser M, et al. Hypoglycemia due to an insulin-secreting small-cell carcinoma of the cervix. N Engl J Med. 1999;341:733–6. https://doi.org/10.1056/NEJM199909023411004 .
doi: 10.1056/NEJM199909023411004 pubmed: 10471459
Ashton MA. Strumal carcinoid of the ovary associated with hyperinsulinaemic hypoglycaemia and cutaneous melanosis. Histopathology. 1995;27:463–7. https://doi.org/10.1111/j.1365-2559.1995.tb00311.x .
doi: 10.1111/j.1365-2559.1995.tb00311.x pubmed: 8575738
Leach SD, LaMorte AI, True LD, Flynn SD, Schwartz PE, Cahow CE, et al. Aberrant hormone production from ovarian neoplasms: strategies for diagnosis and therapy. World J Surg. 1990;14. https://doi.org/10.1007/BF01658520 . 335 – 40; discussion 340-1.
Gray HW, Smith ML, Chung FF, Yogorajah S, Beastall GH. Hyperinsulinism associated with primary renal cell carcinoma. Urology. 1989;33:238–40. https://doi.org/10.1016/0090-4295(89)90401-9 .
doi: 10.1016/0090-4295(89)90401-9 pubmed: 2919487
Morgello S, Schwartz E, Horwith M, King ME, Gorden P, Alonso DR. Ectopic insulin production by a primary ovarian carcinoid. Cancer. 1988;61:800–5. https://doi.org/10.1002/1097-0142(19880215)61:4<800::aid-cncr2820610426>3.0.co;2-3 .
doi: 10.1002/1097-0142(19880215)61:4<800::aid-cncr2820610426>3.0.co;2-3 pubmed: 3276388
Miyazaki K, Funakoshi A, Nishihara S, Wasada T, Koga A, Ibayashi H. Aberrant insulinoma in the duodenum. Gastroenterology. 1986;90:1280–5. https://doi.org/10.1016/0016-5085(86)90397-5 .
doi: 10.1016/0016-5085(86)90397-5 pubmed: 3007262
Shetty MR, Boghossian HM, Duffell D, Freel R, Gonzales JC. Tumor-induced hypoglycemia: a result of ectopic insulin production. Cancer. 1982;49:1920–3. https://doi.org/10.1002/1097-0142(19820501)49:9<1920::aidcncr2820490927>3.0.co;2-m .
doi: 10.1002/1097-0142(19820501)49:9<1920::aidcncr2820490927>3.0.co;2-m pubmed: 6280848
Yoshikawa K, Wakasa H. Hypoglycemia associated with aberrant insulinoma: a case report of 16 years follow-up. Tohoku J Exp Med. 1980;132:17–29. https://doi.org/10.1620/tjem.132.17 .
doi: 10.1620/tjem.132.17 pubmed: 6259773
Ghali F, Hyams ES. Heterotopic pancreatic tail appearing as adrenal mass in a patient with left pelvic kidney. Urology. 2015;85:e37–8. https://doi.org/10.1016/j.urology.2015.01.037 .
doi: 10.1016/j.urology.2015.01.037 pubmed: 25917743
Koh HM, Chang JW, Jeong SY, Hyun CL, Kim YS, Jang BG, et al. Ectopic pancreas presenting as a solid Mediastinal Mass. Int J Surg Pathol. 2015;23:585–8. https://doi.org/10.1177/1066896915596810 .
doi: 10.1177/1066896915596810 pubmed: 26215218
Goodarzi M, Rashid A, Maru D. Invasive ductal adenocarcinoma arising from pancreatic heterotopia in rectum: case report and review of literature. Hum Pathol. 2010;41:1809–13. https://doi.org/10.1016/j.humpath.2010.06.005 .
doi: 10.1016/j.humpath.2010.06.005 pubmed: 20869744
Makhlouf HR, Almeida JL, Sobin LH. Carcinoma in jejunal pancreatic heterotopia. Arch Pathol Lab Med. 1999;123:707–11. https://doi.org/10.5858/1999-123-0707-CIJPH .
doi: 10.5858/1999-123-0707-CIJPH pubmed: 10420228
Service FJ, McMahon MM, O’Brien PC, Ballard DJ. Functioning insulinoma–incidence, recurrence, and long-term survival of patients: a 60-year study. Mayo Clin Proc. 1991;66:711–9. https://doi.org/10.1016/s0025-6196(12)62083-7 .
doi: 10.1016/s0025-6196(12)62083-7 pubmed: 1677058
Okabayashi T, Shima Y, Sumiyoshi T, Kozuki A, Ito S, Ogawa Y, et al. Diagnosis and management of insulinoma. World J Gastroenterol. 2013;19:829–37. https://doi.org/10.3748/wjg.v19.i6.829 .
doi: 10.3748/wjg.v19.i6.829 pubmed: 23430217 pmcid: 3574879
Giannis D, Moris D, Karachaliou GS, Tsilimigras DI, Karaolanis G, Papalampros A, et al. Insulinomas: from diagnosis to treatment. A review of the literature. J BUON. 2020;25:1302–14.
pubmed: 32862570
Placzkowski KA, Vella A, Thompson GB, Grant CS, Reading CC, Charboneau JW, et al. Secular trends in the presentation and management of functioning insulinoma at the Mayo Clinic, 1987–2007. J Clin Endocrinol Metab. 2009;94:1069–73. https://doi.org/10.1210/jc.2008-2031 .
doi: 10.1210/jc.2008-2031 pubmed: 19141587
Borson-Chazot F, Cardot-Bauters C, Mirallie É, Pattou F. French endocrine society. Insulinoma of genetic aetiology. Ann Endocrinol (Paris). 2013;74:200–2. https://doi.org/10.1016/j.ando.2013.05.006 .
doi: 10.1016/j.ando.2013.05.006 pubmed: 23769271
Soga J. Statistical evaluation of 2001 carcinoid cases with metastases, collected from literature: a comparative study between ordinary carcinoids and atypical varieties. J Exp Clin Cancer Res. 1998;17:3–12.
pubmed: 9646227
Low SK, Giannis D, Bahaie NS, Trong BLH, Moris D, Huy NT. Competing mortality in patients with neuroendocrine tumors. Am J Clin Oncol. 2019;42:668–74. https://doi.org/10.1097/COC.0000000000000575 .
doi: 10.1097/COC.0000000000000575 pubmed: 31343423
Ma H, Zhang XP, Zhang Y, Lu HD, Wang JT, Zhang Y, et al. Pancreatic insulinoma misdiagnosed as Epilepsy for eight years: a Case Report and Literature Review. Intern Med. 2015;54:1519–22. https://doi.org/10.2169/internalmedicine.54.3708 .
doi: 10.2169/internalmedicine.54.3708 pubmed: 26267909
Vella A. Insulinoma. UpToDate. 2023. http://www.uptodate.com . Accessed April, 2023.
Burghardt L, Meier JJ, Uhl W, Kahle-Stefan M, Schmidt WE, Nauck MA. Importance of localization of insulinomas: a systematic analysis. J Hepatobiliary Pancreat Sci. 2019;26:383–92. https://doi.org/10.1002/jhbp.642 .
doi: 10.1002/jhbp.642 pubmed: 31211879
Rayamajhi SJ, Lee J, Mittal BR, Jessop AC, Chasen B, Bhosale P. Cross sectional and nuclear medicine imaging of pancreatic insulinomas. Abdom Radiol (NY). 2017;42:531–43. https://doi.org/10.1007/s00261-016-0904-7 .
doi: 10.1007/s00261-016-0904-7 pubmed: 27639564
Antwi K, Fani M, Nicolas G, Rottenburger C, Heye T, Reubi JC, et al. Localization of Hidden Insulinomas with
doi: 10.2967/jnumed.115.157768 pubmed: 25999434
Luo Y, Yu M, Pan Q, Wu W, Zhang T, Kiesewetter DO, et al. 68Ga-NOTA-exendin-4 PET/CT in detection of occult insulinoma and evaluation of physiological uptake. Eur J Nucl Med Mol Imaging. 2015;42:531–2. https://doi.org/10.1007/s00259-014-2946-9 .
doi: 10.1007/s00259-014-2946-9 pubmed: 25398421
Luo Y, Li N, Kiesewetter DO, Chen X, Li F. 68Ga-NOTA-Exendin-4 PET/CT in localization of an Occult Insulinoma and Appearance of coexisting esophageal carcinoma. Clin Nucl Med. 2016;41:341–3. https://doi.org/10.1097/RLU.0000000000001087 .
doi: 10.1097/RLU.0000000000001087 pubmed: 26647001 pmcid: 4779726
Prasad V, Sainz-Esteban A, Arsenic R, Plöckinger U, Denecke T, Pape UF, et al. Role of (68)Ga somatostatin receptor PET/CT in the detection of endogenous hyperinsulinaemic focus: an explorative study. Eur J Nucl Med Mol Imaging. 2016;43:1593–600. https://doi.org/10.1007/s00259-016-3331-7 .
doi: 10.1007/s00259-016-3331-7 pubmed: 26923247
Shah R, Garg R, Majmundar M, Purandare N, Malhotra G, Patil V, et al. Exendin-4-based imaging in insulinoma localization: systematic review and meta-analysis. Clin Endocrinol (Oxf). 2021;95:354–64. https://doi.org/10.1111/cen.14406 .
doi: 10.1111/cen.14406 pubmed: 33386617
Kann PH, Moll R, Bartsch D, Pfützner A, Forst T, Tamagno G, et al. Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA) in insulinomas: indications and clinical relevance in a single investigator cohort of 47 patients. Endocrine. 2017;56:158–63. https://doi.org/10.1007/s12020-016-1179-z .
doi: 10.1007/s12020-016-1179-z pubmed: 27905047
Wang H, Ba Y, Xing Q, Cai RC. Diagnostic value of ASVS for insulinoma localization: a systematic review and meta-analysis. PLoS ONE. 2019;14:e0224928. https://doi.org/10.1371/journal.pone.0224928 .
doi: 10.1371/journal.pone.0224928 pubmed: 31743337 pmcid: 6863549
Mehrabi A, Fischer L, Hafezi M, Dirlewanger A, Grenacher L, Diener MK, et al. A systematic review of localization, surgical treatment options, and outcome of insulinoma. Pancreas. 2014;43:675–86. https://doi.org/10.1097/MPA.0000000000000110 .
doi: 10.1097/MPA.0000000000000110 pubmed: 24921202
Aggeli C, Nixon AM, Karoumpalis I, Kaltsas G, Zografos GN. Laparoscopic surgery for pancreatic insulinomas: an update. Horm (Athens). 2016;15:157–69. https://doi.org/10.14310/horm.2002.1670 .
doi: 10.14310/horm.2002.1670
Qin S, Liu Y, Ning H, Tao L, Luo W, Lu D, et al. EUS-guided lauromacrogol ablation of insulinomas: a novel treatment. Scand J Gastroenterol. 2018;53:616–20. https://doi.org/10.1080/00365521.2017.1402206 .
doi: 10.1080/00365521.2017.1402206 pubmed: 29141488
Qin SY, Lu XP, Jiang HX. EUS-guided ethanol ablation of insulinomas: case series and literature review. Med (Baltim). 2014;93:e85. https://doi.org/10.1097/MD.0000000000000085 .
doi: 10.1097/MD.0000000000000085
Berwaerts J, Verhelst J, Hubens H, Kunnen J, Schrijvers D, Joosens E, et al. Role of hepatic arterial embolisation in the treatment for metastatic insulinoma. Report of two cases and review of the literature. Acta Clin Belg. 1997;52:263–74. https://doi.org/10.1080/17843286.1997.11718588 .
doi: 10.1080/17843286.1997.11718588 pubmed: 9489120
Cigrovski Berkovic M, Ulamec M, Marinovic S, Balen I, Mrzljak A. Malignant insulinoma: can we predict the long-term outcomes? World J Clin Cases. 2022;10:5124–32. https://doi.org/10.12998/wjcc.v10.i16.5124 .
doi: 10.12998/wjcc.v10.i16.5124 pubmed: 35812675 pmcid: 9210919
Magalhães D, Sampaio IL, Ferreira G, Bogalho P, Martins-Branco D, Santos R, et al. Peptide receptor radionuclide therapy with
doi: 10.1007/s40618-018-0911-3 pubmed: 29949120
Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR, et al. Improved contemporary surgical management of insulinomas: a 25-year experience at the Massachusetts General Hospital. Ann Surg. 2008;247:165–72. https://doi.org/10.1097/SLA.0b013e31815792ed .
doi: 10.1097/SLA.0b013e31815792ed pubmed: 18156937
Crippa S, Zerbi A, Boninsegna L, Capitanio V, Partelli S, Balzano G, et al. Surgical management of insulinomas: short- and long-term outcomes after enucleations and pancreatic resections. Arch Surg. 2012;147:261–6. https://doi.org/10.1001/archsurg.2011.1843 .
doi: 10.1001/archsurg.2011.1843 pubmed: 22430908

Auteurs

Fernando Guerrero-Pérez (F)

Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain. fguerrerop@bellvitgehospital.cat.
Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. fguerrerop@bellvitgehospital.cat.
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. fguerrerop@bellvitgehospital.cat.
ORCID: 0000-0002-4165-4356

Nuria Vilarrasa (N)

Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain.
Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
ORCID: 0000-0003-3188-1990

Lidia V Huánuco (LV)

Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain.
Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

Juli Busquets (J)

Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Hepatobiliary and Pancreatic Surgery, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Lluis Secanella (L)

Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Hepatobiliary and Pancreatic Surgery, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

José L Vercher-Conejero (JL)

Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Nuclear Medicine-PET Unit, University Hospital Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Noemi Vidal (N)

Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Department of Pathology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.

Silvia Näf Cortés (S)

Department of Endocrinology, Joan XXIII University Hospital, Tarragona, Spain.

Carles Villabona (C)

Department of Endocrinology, Bellvitge University Hospital, Barcelona, Spain.
Biomedical Research Institute of Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.

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Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
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Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du glucose › Hypoglycémie › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Adénome langerhansien › Insulinome › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Tomographie par émission de positons couplée à la tomodensitométrie › Ectopic insulinoma: a systematic review.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypothalamiques hypophysotropes inhibitrices › Somatostatine › Ectopic insulinoma: a systematic review.