Predictive value of triglycerides to high-density lipoprotein cholesterol and triglyceride glycemic index for diabetes incidence in pre-diabetes patients: a prospective cohort study.
Cox regression model
Diabetes
Fasa Persian cohort study
Pre-diabetes
Triglyceride glucose index
Triglyceride-to-high-density lipoprotein cholesterol ratio
Journal
Journal of health, population, and nutrition
ISSN: 2072-1315
Titre abrégé: J Health Popul Nutr
Pays: Bangladesh
ID NLM: 100959228
Informations de publication
Date de publication:
11 07 2023
11 07 2023
Historique:
received:
26
04
2023
accepted:
28
06
2023
medline:
13
7
2023
pubmed:
12
7
2023
entrez:
11
7
2023
Statut:
epublish
Résumé
The triglyceride glucose (TyG) and triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-c) are the indices that can predict the progression of pre-diabetes to type 2 diabetes mellitus (T2DM). This study aimed to examine the relationship between TyG and TG/HDL-c indices with the incidence of T2DM in pre-diabetes patients. A total of 758 pre-diabetic patients aged 35-70 years who were enrolled in a prospective Fasa Persian Adult Cohort were followed up for 60 months. TyG and TG/HDL-C indices were obtained at baseline data and divided into quartiles. The 5-year cumulative incidence of T2DM was analyzed by Cox proportional hazards regression analysis while controlling for baseline covariates. During 5 years of follow-up, there were 95 incident cases of T2DM, with an overall incidence rate of 12.53%. After adjusting for age, sex, smoking, marital status, socioeconomic status, body mass index, waist circumference, hip circumference, hypertension, total cholesterol, and dyslipidemia, the multivariate-adjusted hazard ratios (HRs) demonstrated that patients with the highest TyG and TG/HDL-C indices quartile were at higher risk of T2DM (HR = 4.42, 95%CI 1.75-11.21) and (HR = 2.15, 95%CI 1.04-4.47), respectively, compared to participants in the lowest quartile. As the quantiles of these indices increase, the HR value shows a significant increment (P < 0.05). The results of our study showed that the TyG and TG/HDL-C indices can be important independent predictors for the progression of pre-diabetes to T2DM. Therefore, controlling the components of these indicators in pre-diabetes patients can prevent developing T2DM or delay its occurrence.
Sections du résumé
BACKGROUND
The triglyceride glucose (TyG) and triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-c) are the indices that can predict the progression of pre-diabetes to type 2 diabetes mellitus (T2DM). This study aimed to examine the relationship between TyG and TG/HDL-c indices with the incidence of T2DM in pre-diabetes patients.
METHODS
A total of 758 pre-diabetic patients aged 35-70 years who were enrolled in a prospective Fasa Persian Adult Cohort were followed up for 60 months. TyG and TG/HDL-C indices were obtained at baseline data and divided into quartiles. The 5-year cumulative incidence of T2DM was analyzed by Cox proportional hazards regression analysis while controlling for baseline covariates.
RESULTS
During 5 years of follow-up, there were 95 incident cases of T2DM, with an overall incidence rate of 12.53%. After adjusting for age, sex, smoking, marital status, socioeconomic status, body mass index, waist circumference, hip circumference, hypertension, total cholesterol, and dyslipidemia, the multivariate-adjusted hazard ratios (HRs) demonstrated that patients with the highest TyG and TG/HDL-C indices quartile were at higher risk of T2DM (HR = 4.42, 95%CI 1.75-11.21) and (HR = 2.15, 95%CI 1.04-4.47), respectively, compared to participants in the lowest quartile. As the quantiles of these indices increase, the HR value shows a significant increment (P < 0.05).
CONCLUSION
The results of our study showed that the TyG and TG/HDL-C indices can be important independent predictors for the progression of pre-diabetes to T2DM. Therefore, controlling the components of these indicators in pre-diabetes patients can prevent developing T2DM or delay its occurrence.
Identifiants
pubmed: 37434259
doi: 10.1186/s41043-023-00410-5
pii: 10.1186/s41043-023-00410-5
pmc: PMC10334632
doi:
Substances chimiques
Triglycerides
0
Lipoproteins, HDL
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
67Informations de copyright
© 2023. The Author(s).
Références
Metabolism. 2012 Jan;61(1):30-6
pubmed: 21664631
Med Arch. 2019 Jun;73(3):163-168
pubmed: 31404127
J Clin Res Pediatr Endocrinol. 2019 May 15;:
pubmed: 31088046
Diabetes Metab J. 2011 Apr;35(2):107-16
pubmed: 21738892
Diabetes Care. 2005 Mar;28(3):617-25
pubmed: 15735198
Sci Rep. 2022 Jul 7;12(1):11504
pubmed: 35798768
J Transl Med. 2016 Sep 07;14:260
pubmed: 27604550
Endocrine. 2021 Apr;72(1):124-131
pubmed: 33433893
Diabetes Res Clin Pract. 2020 May;163:108150
pubmed: 32305400
Cardiovasc Diabetol. 2021 May 26;20(1):113
pubmed: 34039351
Int J Mol Sci. 2014 Apr 11;15(4):6184-223
pubmed: 24733068
Am J Cardiol. 2008 Feb 15;101(4):497-501
pubmed: 18312765
Cardiovasc Diabetol. 2011 Oct 17;10:93
pubmed: 22004541
J Pediatr Endocrinol Metab. 2019 Oct 25;32(10):1163-1170
pubmed: 31472061
J Diabetes Investig. 2021 Oct;12(10):1864-1871
pubmed: 33650324
Int J Epidemiol. 2023 Jun 6;52(3):e172-e178
pubmed: 36592077
Med J Islam Repub Iran. 2021 Jun 16;35:78
pubmed: 34291002
BMJ Open Diabetes Res Care. 2020 Mar;8(1):
pubmed: 32205325
Transl Res. 2021 Feb;228:42-51
pubmed: 32827706
Middle East J Dig Dis. 2018 Jul;10(3):180-187
pubmed: 30186582
PLoS One. 2016 Sep 28;11(9):e0163465
pubmed: 27682598
Prim Care Diabetes. 2020 Apr;14(2):161-167
pubmed: 31466834
Nat Rev Nephrol. 2020 Apr;16(4):223-237
pubmed: 32024986
J Investig Med. 2014 Feb;62(2):345-9
pubmed: 24402298
Lipids Health Dis. 2020 Mar 4;19(1):33
pubmed: 32131838
BMC Med. 2020 Nov 25;18(1):361
pubmed: 33234146
Diabetes Res Clin Pract. 2011 Sep;93(3):e98-e100
pubmed: 21665314
Diabetes Res Clin Pract. 2022 Jan;183:109119
pubmed: 34879977
J Diabetes. 2019 Mar;11(3):183-192
pubmed: 30091266
Diabetes Care. 2019 Jan;42(Suppl 1):S13-S28
pubmed: 30559228
Atherosclerosis. 2015 Sep;242(1):243-50
pubmed: 26232164
Eur J Clin Invest. 2016 Feb;46(2):189-97
pubmed: 26683265
Diabetol Metab Syndr. 2018 Oct 05;10:74
pubmed: 30323862