Effect of chromosomal polymorphisms on the outcome of in vitro fertilization and embryo transfer.
chromosomal polymorphisms
clinical pregnancy rate
embryo quality
embryo transfer
in vitro fertilization
Journal
The journal of obstetrics and gynaecology research
ISSN: 1447-0756
Titre abrégé: J Obstet Gynaecol Res
Pays: Australia
ID NLM: 9612761
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
26
12
2022
accepted:
17
06
2023
medline:
6
9
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
ppublish
Résumé
The incidence of chromosomal polymorphisms (CP) is increased in infertile couples, but its impact on reproduction is uncertain, especially undergoing assisted reproductive technology treatment. The purpose of the present study was to investigate the effect of CP on the outcomes of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) treatment METHODS: A total of 1331 infertile couples undergoing IVF/ICSI treatment were involved in this retrospective case-control study. The participants were divided into 4 groups according to CP variations: (i) normal chromosomes (NC) group; (ii) CP group; (iii) both chromosomal polymorphisms (BCP) group; and (iv) double chromosomal polymorphisms (DCP) group. The CP group was further divided into five subgroups: qh+, D/G, inv(9), Yqh+ and Yqh-. The outcomes of IVF/ICSI-ET treatment were compared among the groups. There were no differences observed between the eight groups in terms of number of oocytes retrieved, MII rate, fertilization rate, cleaved embryo rate, and quality embryo rate for both females and males (p > 0.05). In both male and female, some of the CP subgroups experienced more oocyte retrieval operations and more embryo transfer operations to achieve pregnancy than the NC groups (p < 0.05). The rates of live births were significantly lower in some of the CP subgroups compared to the NC group (p < 0.05). In conclusion, the pregnancy outcomes of ET were affected by CP. It was speculated that this may be associated with the effect of chromosome polymorphism on embryo quality, although this could not be observed or determined by morphological evaluation.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2351-2360Subventions
Organisme : Innovation plan of Medical Science and Technology of "Four in a batch"
ID : 2020TD19
Organisme : the Hospital Foundation of Shanxi Maternal and Child Health Hospital
ID : 2022041
Informations de copyright
© 2023 The Authors. Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology.
Références
Hong Y, Zhou YW, Tao J, Wang SX, Zhao XM. Do polymorphic variants of chromosomes affect the outcome of in vitro fertilization and embryo transfer treatment? Hum Reprod. 2011;26(4):933-40. https://doi.org/10.1093/humrep/deq333
Lee KB, Kunugi H, Nanko S. Familial schizophrenia with pericentric inversion of chromosome 9: a case report. Schizophr Res. 1998;32(2):123-6. https://doi.org/10.1016/s0920-9964(98)00031-0
Serra A, Brahe C, Millington-Ward A, Neri G, Tedeschi B, Tassone F, et al. Pericentric inversion of chromosome 9: prevalence in 300 Down syndrome families and molecular studies of nondisjunction. Am J Med Genet Suppl. 1990;7:162-8. https://doi.org/10.1002/ajmg.1320370733
Uehara S, Akai Y, Takeyama Y, Takabayashi T, Okamura K, Yajima A. Pericentric inversion of chromosome 9 in prenatal diagnosis and infertility. Tohoku J Exp Med. 1992;166(4):417-27. https://doi.org/10.1620/tjem.166.417
Li SJ, Cheng YX, Ye S, Zhou DN, Zhang Y, Yin TL, et al. Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET. J Assist Reprod Genet. 2020;37(7):1703-10. https://doi.org/10.1007/s10815-020-01793-8
Sahin FI, Yilmaz Z, Yuregir OO, Bulakbasi T, Ozer O, Zeyneloglu HB. Chromosome heteromorphisms: an impact on infertility. J Assist Reprod Genet. 2008;25(5):191-5. https://doi.org/10.1007/s10815-008-9216-3
Madon PF, Athalye AS, Parikh FR. Polymorphic variants on chromosomes probably play a significant role in infertility. Reprod Biomed Online. 2005;11(6):726-32. https://doi.org/10.1016/s1472-6483(10)61691-4
Minocherhomji S, Athalye AS, Madon PF, Kulkarni D, Uttamchandani SA, Parikh FR. A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype. Fertil Steril. 2009;92(1):88-95. https://doi.org/10.1016/j.fertnstert.2008.05.071
Guo T, Qin Y, Gao X, Chen H, Li G, Ma J, et al. The role of male chromosomal polymorphism played in spermatogenesis and the outcome of IVF/ICSI-ET treatment. Int J Androl. 2012;35(6):802-9. https://doi.org/10.1111/j.1365-2605.2012.01284.x
Arce JC, Ziebe S, Lundin K, Janssens R, Helmgaard L, Sørensen P. Interobserver agreement and intraobserver reproducibility of embryo quality assessments. Hum Reprod. 2006;21(8):2141-8. https://doi.org/10.1093/humrep/del106
Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270-83. https://doi.org/10.1093/humrep/der037
Bhasin M. Human population cytogenetics: a review. Int J HumGenet. 2005;5:83.
Vinci G, Raicu F, Popa L, Popa O, Cocos R, McElreavey K. A deletion of a novel heat shock gene on the Y chromosome associated with azoospermia. Mol Hum Reprod. 2005;11(4):295-8. https://doi.org/10.1093/molehr/gah153
Šípek A Jr, Panczak A, Mihalová R, Hrčková L, Suttrová E, Sobotka V, et al. Pericentric inversion of human chromosome 9 epidemiology study in Czech males and females. Folia Biol (Praha). 2015;61(4):140-6.
Cheng R, Ma Y, Nie Y, Qiao X, Yang Z, Zeng R, et al. Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study. Reprod Biomed Online. 2017;35(1):72-80. https://doi.org/10.1016/j.rbmo.2017.03.022
Antonelli A, Gandini L, Petrinelli P, Marcucci L, Elli R, Lombardo F, et al. Chromosomal alterations and male infertility. J Endocrinol Invest. 2000;23(10):677-83. https://doi.org/10.1007/BF03343793
Pan Y, Zhang HG, Xi QI, Zhang H, Wang RX, Li LL, et al. Molecular microdeletion analysis of infertile men with karyotypic Y chromosome abnormalities. J Int Med Res. 2018;46(1):307-15. https://doi.org/10.1177/0300060517719394
Shinka T, Sato Y, Chen G, Naroda T, Kinoshita K, Unemi Y, et al. Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. Biol Reprod. 2004;71(1):297-306. https://doi.org/10.1095/biolreprod.103.023580
Murthy SK, Prabhakara K. Mitotic disturbances associated with inversion 9qh. A Case Report Ann Genet. 1990;33(3):169-72.
Belangero SI, Christofolini DM, Bianco B, Gava MM, Wroclawski ER, Barbosa CP. Male infertility related to an aberrant karyotype, 46,XY,9ph,9qh+. Fertil Steril. 2009;91(6):2732.e1-2732.e27323. https://doi.org/10.1016/j.fertnstert.2008.10.057
Karpen G, Endow S. Meiosis: chromosome behaviour and spindle dynamics. In: Endow S, Glover D, editors. Frontiers in biology. Oxford: Oxford University Press; 1998.
Morales R, Lledó B, Ortiz JA, Ten J, Llácer J, Bernabeu R. Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos. Syst Biol Reprod Med. 2016;62(5):317-24. https://doi.org/10.1080/19396368.2016.1212949
Yilmaz A, Zhang L, Zhang XY, Son WY, Holzer H, Ao A. Chromosomal complement and clinical relevance of multinucleated embryos in PGD and PGS cycles. Reprod Biomed Online. 2014;28(3):380-7. https://doi.org/10.1016/j.rbmo.2013.11.003
Sun L, Chen ZH, Yang L, Yi CX, Liu J, Ou CQ. Chromosomal polymorphisms are independently associated with multinucleated embryo formation. J Assist Reprod Genet. 2018;35(1):149-56. https://doi.org/10.1007/s10815-017-1037-9