Visualization of the protein-protein interactions of hormone receptors in hormone-dependent cancer research.
breast cancer
prostate cancer
protein–protein interactions
proximity ligation assay
steroid hormone receptor
Journal
Endocrine oncology (Bristol, England)
ISSN: 2634-4793
Titre abrégé: Endocr Oncol
Pays: England
ID NLM: 9918540584106676
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
30
08
2022
accepted:
03
10
2022
medline:
12
7
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
epublish
Résumé
In hormone-dependent cancers, the activation of hormone receptors promotes the progression of cancer cells. Many proteins exert their functions through protein-protein interactions (PPIs). Moreover, in such cancers, hormone-hormone receptor binding, receptor dimerization, and cofactor mobilization PPIs occur primarily in hormone receptors, including estrogen, progesterone, glucocorticoid, androgen, and mineralocorticoid receptors. The visualization of hormone signaling has been primarily reported by immunohistochemistry using specific antibodies; however, the visualization of PPIs is expected to improve our understanding of hormone signaling and disease pathogenesis. Visualization techniques for PPIs include Förster resonance energy transfer (FRET) and bimolecular fluorescence complementation analysis; however, these techniques require the insertion of probes in the cells for PPI detection. Proximity ligation assay (PLA) is a method that could be used for both formalin-fixed paraffin-embedded (FFPE) tissue as well as immunostaining. It can also visualize hormone receptor localization and post-translational modifications of hormone receptors. This review summarizes the results of recent studies on visualization techniques for PPIs with hormone receptors; these techniques include FRET and PLA. In addition, super-resolution microscopy has been recently reported to be applicable to their visualization in both FFPE tissues and living cells. Super-resolution microscopy in conjunction with PLA and FRET could also contribute to the visualization of PPIs and subsequently provide a better understanding of the pathogenesis of hormone-dependent cancers in the future.
Identifiants
pubmed: 37435453
doi: 10.1530/EO-22-0059
pii: EO-22-0059
pmc: PMC10259353
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
R132-R142Informations de copyright
© The authors.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of this review.
Références
Asian J Urol. 2020 Jul;7(3):191-202
pubmed: 32742923
J Biol Chem. 1998 Mar 6;273(10):5455-60
pubmed: 9488667
Nat Methods. 2006 Dec;3(12):995-1000
pubmed: 17072308
Biol Reprod. 2021 Feb 11;104(2):445-456
pubmed: 33048113
Front Endocrinol (Lausanne). 2020 Oct 07;11:568375
pubmed: 33117284
Front Endocrinol (Lausanne). 2021 Jan 21;11:612396
pubmed: 33552000
Life Sci Alliance. 2019 Aug 20;2(4):
pubmed: 31431473
Mol Cell Proteomics. 2013 Jul;12(7):1764-79
pubmed: 23339905
Acta Histochem Cytochem. 2021 Dec 24;54(6):177-183
pubmed: 35023880
Cell Death Dis. 2019 Sep 9;10(9):652
pubmed: 31501416
J Amino Acids. 2011;2011:812540
pubmed: 22312471
Steroids. 2018 May;133:2-7
pubmed: 29155216
Mol Endocrinol. 2003 Apr;17(4):589-99
pubmed: 12554772
J Biol Chem. 2014 Mar 28;289(13):8839-51
pubmed: 24523409
Cell. 1995 Dec 15;83(6):835-9
pubmed: 8521507
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Breast Cancer Res. 2020 May 19;22(1):50
pubmed: 32429997
Cell Commun Signal. 2020 Sep 18;18(1):154
pubmed: 32948192
Cells. 2021 Oct 31;10(11):
pubmed: 34831189
Mol Cell Endocrinol. 2021 Jun 15;530:111282
pubmed: 33894309
Cancer Res. 2009 Mar 15;69(6):2305-13
pubmed: 19244107
BMC Biochem. 2013 Apr 08;14:10
pubmed: 23566155
Biochem Biophys Res Commun. 2005 Nov 4;336(4):1023-7
pubmed: 16165085
Steroids. 2003 Nov;68(10-13):771-8
pubmed: 14667967
Mol Endocrinol. 2009 Mar;23(3):292-307
pubmed: 19116244
Mol Med. 2014 Oct 02;20:427-34
pubmed: 25032955
PLoS One. 2020 Jan 10;15(1):e0227520
pubmed: 31923266
J Biol Chem. 2002 Feb 15;277(7):5209-18
pubmed: 11717311
Int J Proteomics. 2014;2014:147648
pubmed: 24693427
Int J Mol Sci. 2018 Oct 15;19(10):
pubmed: 30326622
FEBS Lett. 2010 Jun 18;584(12):2510-5
pubmed: 20303958
Nat Rev Mol Cell Biol. 2006 Jun;7(6):449-56
pubmed: 16625152
Int J Mol Sci. 2021 Mar 04;22(5):
pubmed: 33806648
Front Plant Sci. 2013 Oct 29;4:413
pubmed: 24194740
Clin Chem. 2010 Jan;56(1):99-110
pubmed: 19926775
Mol Cell Endocrinol. 2003 Mar 28;201(1-2):165-75
pubmed: 12706304
Int J Mol Sci. 2021 Apr 24;22(9):
pubmed: 33923160
Structure. 2015 Dec 1;23(12):2280-2290
pubmed: 26602186
Oncogene. 2022 Feb;41(7):943-959
pubmed: 34667276
Mol Endocrinol. 2005 Apr;19(4):843-54
pubmed: 15637147
Methods. 2020 Mar 15;175:66-71
pubmed: 31499160
J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):159-169
pubmed: 27264933
Mol Endocrinol. 2007 Jan;21(1):14-29
pubmed: 17021053
Breast Cancer. 2022 Jan;29(1):144-155
pubmed: 34498219
Mod Pathol. 2010 May;23 Suppl 2:S52-9
pubmed: 20436503
Nat Commun. 2017 Feb 06;8:14388
pubmed: 28165461
Sci Rep. 2017 Apr 24;7(1):1109
pubmed: 28439080
EMBO Mol Med. 2014 Sep 11;6(10):1328-46
pubmed: 25214462
J Biol Chem. 1999 Sep 24;274(39):27857-66
pubmed: 10488132
Sci Adv. 2016 Jun 24;2(6):e1501924
pubmed: 27386569
Cells. 2022 Feb 15;11(4):
pubmed: 35203332
Breast Cancer Res Treat. 2020 Feb;180(1):97-110
pubmed: 31989378
Br J Cancer. 2018 Nov;119(11):1316-1325
pubmed: 30410061
J Biol Chem. 1996 Apr 19;271(16):9550-9
pubmed: 8621628
Endocrinology. 2019 Nov 1;160(11):2692-2708
pubmed: 31433456
Endocr Relat Cancer. 2011 Sep 20;18(5):R183-96
pubmed: 21778211
Br J Cancer. 2021 Jan;124(1):217-227
pubmed: 33144693
Nature. 2017 Aug 3;548(7665):97-102
pubmed: 28746306
Endocr Relat Cancer. 2019 Aug;26(8):R479-R497
pubmed: 31252411
Acta Histochem Cytochem. 2017 Apr 27;50(2):85-93
pubmed: 28522883
Br J Cancer. 2006 Nov 6;95(9):1220-8
pubmed: 17043687
J Cell Biol. 2010 Jul 26;190(2):165-75
pubmed: 20643879
Nature. 2015 Jul 16;523(7560):313-7
pubmed: 26153859
Cancer Res. 2015 Sep 1;75(17):3663-71
pubmed: 26060018