Dysfunction of ubiquitin protein ligase
Journal
NAR cancer
ISSN: 2632-8674
Titre abrégé: NAR Cancer
Pays: England
ID NLM: 101769553
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
26
04
2023
accepted:
26
06
2023
medline:
12
7
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
epublish
Résumé
Breast cancer is the most common type of cancer among women worldwide, and it is estimated that 294 000 new diagnoses and 37 000 deaths will occur each year in the United States alone by 2030. Large-scale genomic studies have identified a number of genetic loci with alterations in breast cancer. However, identification of the genes that are critical for tumorgenicity still remains a challenge. Here, we perform a comprehensive functional multi-omics analysis of somatic mutations in breast cancer and identify previously unknown key regulators of breast cancer tumorgenicity. We identify dysregulation of
Identifiants
pubmed: 37435531
doi: 10.1093/narcan/zcad036
pii: zcad036
pmc: PMC10331931
doi:
Types de publication
Journal Article
Langues
eng
Pagination
zcad036Subventions
Organisme : NIA NIH HHS
ID : U01 AG046170
Pays : United States
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Cancer.
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