The association of childhood trauma with depressive and negative symptoms in recent onset psychosis: a sex-specific analysis.

Childhood trauma depressive symptoms first-episode psychosis negative symptoms psychosis schizophrenia sex

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
12 Jul 2023
Historique:
medline: 12 7 2023
pubmed: 12 7 2023
entrez: 12 7 2023
Statut: aheadofprint

Résumé

Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific. A total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men: Women reported higher rates of sexual abuse than men (23.5% Depressive symptom severity was associated with different types of trauma in men and women with recent-onset SSD. Specifically, in women, depressive symptom severity was associated with childhood sexual abuse, which was reported three times as often as in men. Our results emphasize the importance of sex-specific analyses in SSD research.

Sections du résumé

BACKGROUND BACKGROUND
Childhood trauma may impact the course of schizophrenia spectrum disorders (SSD), specifically in relation to the increased severity of depressive or negative symptoms. The type and impact of trauma may differ between sexes. In a large sample of recent-onset patients, we investigated the associations of depressive and negative symptoms with childhood trauma and whether these are sex-specific.
METHODS METHODS
A total of 187 first-episode psychosis patients in remission (Handling Antipsychotic Medication: Long-term Evaluation of Targeted Treatment study) and 115 recent-onset SSD patients (Simvastatin study) were included in this cross-sectional study (men:
RESULTS RESULTS
Women reported higher rates of sexual abuse than men (23.5%
CONCLUSIONS CONCLUSIONS
Depressive symptom severity was associated with different types of trauma in men and women with recent-onset SSD. Specifically, in women, depressive symptom severity was associated with childhood sexual abuse, which was reported three times as often as in men. Our results emphasize the importance of sex-specific analyses in SSD research.

Identifiants

DOI: 10.1017/S0033291723001824 PMID: 37435649
pubmed: 37435649
doi: 10.1017/S0033291723001824
pii: S0033291723001824
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-10

Subventions

Organisme : ZonMw
ID : 80-84800-98-41015
Pays : Netherlands

Auteurs

Anne-Sophie D Enthoven (AD)

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
ORCID: 0000-0001-7268-2950

Shiral S Gangadin (SS)

Department of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Lieuwe de Haan (L)

Department of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, The Netherlands.

Wim Veling (W)

Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Erik F J de Vries (EFJ)

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Janine Doorduin (J)

Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Marieke J H Begemann (MJH)

Department of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Iris E C Sommer (IEC)

Department of Biomedical Sciences of Cells and Systems, and Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Classifications MeSH