Increased transferrin protects from thrombosis in Chuvash erythrocytosis.

Humans Polycythemia / genetics Transferrin Von Hippel-Lindau Tumor Suppressor Protein / genetics Thrombosis / genetics Hypoxia Erythropoietin / genetics Ferritins Iron Deficiencies

Journal

American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369

Informations de publication

Date de publication:
10 2023
Historique:
revised: 19 06 2023
received: 13 06 2023
accepted: 30 06 2023
pmc-release: 01 10 2024
medline: 11 9 2023
pubmed: 12 7 2023
entrez: 12 7 2023
Statut: ppublish

Résumé

Von Hippel-Lindau protein (VHL) is essential to hypoxic regulation of cellular processes. VHL promotes proteolytic clearance of hypoxia-inducible transcription factors (HIFs) that have been modified by oxygen-dependent HIF-prolyl hydroxylases. A homozygous loss-of-function VHL

Identifiants

DOI: 10.1002/ajh.27021 PMID: 37435906 PMC: PMC10529798
pubmed: 37435906
doi: 10.1002/ajh.27021
pmc: PMC10529798
mid: NIHMS1915724
doi:

Substances chimiques

Transferrin 0
Von Hippel-Lindau Tumor Suppressor Protein EC 2.3.2.27
Erythropoietin 11096-26-7
Ferritins 9007-73-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1532-1539

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL137991
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL090508
Pays : United States
Organisme : NHLBI NIH HHS
ID : P50 HL118006
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA108671
Pays : United States
Organisme : NHLBI NIH HHS
ID : R25 HL003679
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL079912
Pays : United States
Organisme : NHLBI NIH HHS
ID : U10 HL083748
Pays : United States

Informations de copyright

© 2023 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.

Références

Haematologica. 2012 Feb;97(2):193-200
pubmed: 21993671
Aging (Albany NY). 2023 Mar 27;15(6):2237-2274
pubmed: 36988549
Haematologica. 2017 May;102(5):e166-e169
pubmed: 28104701
Ann Hematol. 2008 Mar;87(3):167-73
pubmed: 18066546
Cell Res. 2020 Feb;30(2):119-132
pubmed: 31811276
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
Haematologica. 2008 Feb;93(2):279-82
pubmed: 18223282
J Mol Med (Berl). 2013 Jan;91(1):59-67
pubmed: 23015148
Biochim Biophys Acta. 2016 Apr;1862(4):670-678
pubmed: 26826018
Cold Spring Harb Perspect Med. 2013 Mar 01;3(3):a011619
pubmed: 23457296
Nat Genet. 2002 Dec;32(4):614-21
pubmed: 12415268
Am J Hum Genet. 2022 Sep 1;109(9):1638-1652
pubmed: 36055212
Stroke. 1996 May;27(5):1002-5
pubmed: 8623090
Circulation. 1994 Jan;89(1):102-8
pubmed: 8281634
Science. 1988 Dec 9;242(4884):1412-5
pubmed: 2849206
Circ Res. 2020 Aug 14;127(5):651-663
pubmed: 32450779
Biostatistics. 2007 Apr;8(2):485-99
pubmed: 17189563
J Biol Chem. 1997 Aug 8;272(32):20055-62
pubmed: 9242677
Blood. 2023 Apr 27;141(17):2042-2044
pubmed: 37103951
Stat Methods Med Res. 2017 Oct;26(5):2333-2355
pubmed: 26282889
Am J Hematol. 2022 Feb 1;97(2):E37-E40
pubmed: 34748652
Blood. 2023 Apr 27;141(17):2127-2140
pubmed: 36758212
Blood Adv. 2020 Mar 24;4(6):1115-1130
pubmed: 32203583
Physiology (Bethesda). 2009 Apr;24:97-106
pubmed: 19364912
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Am J Hematol. 2020 Jul 3;:
pubmed: 32619079
Front Pediatr. 2022 Aug 01;10:926925
pubmed: 35979407
Blood Adv. 2019 Nov 26;3(22):3713-3723
pubmed: 31765479
Blood Adv. 2023 Mar 14;7(5):712-717
pubmed: 36343116
J Clin Invest. 2003 Mar;111(6):779-83
pubmed: 12639980
Probl Gematol Pereliv Krovi. 1974 Oct;19(10):30-3
pubmed: 4431763
Haematologica. 2020 Mar;105(3):e87-e90
pubmed: 31289208
Stroke. 1990 Mar;21(3):488-93
pubmed: 2309275
Blood Cells Mol Dis. 2014 Jan;52(1):35-45
pubmed: 23993337
Science. 2001 Apr 20;292(5516):468-72
pubmed: 11292861
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Curr Med Chem. 2007;14(17):1853-62
pubmed: 17627521
Blood. 2022 Nov 10;140(19):2063-2075
pubmed: 36040436
Nat Struct Mol Biol. 2007 May;14(5):420-6
pubmed: 17417656
J Am Heart Assoc. 2019 Aug 6;8(15):e012994
pubmed: 31310728
Diagnostics (Basel). 2020 Jul 30;10(8):
pubmed: 32751741
Semin Thromb Hemost. 2010 Jul;36(5):537-49
pubmed: 20632251
JCI Insight. 2017 Feb 23;2(4):e91700
pubmed: 28239661
Nat Methods. 2011 Dec 04;9(2):179-81
pubmed: 22138821
J Clin Invest. 2022 Feb 1;132(3):
pubmed: 34793333
Blood. 2011 Nov 10;118(19):5278-82
pubmed: 21876117
Sci Transl Med. 2022 Aug 31;14(660):eabj7465
pubmed: 36044595
Am J Hum Genet. 2009 Jan;84(1):60-5
pubmed: 19084217
Blood. 2004 May 15;103(10):3924-32
pubmed: 14726398

Auteurs

Binal N Shah (BN)

Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
ORCID: 0000-0001-5169-7301

Xu Zhang (X)

Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
ORCID: 0000-0002-7732-1385

Adelina I Sergueeva (AI)

Department of Pediatric Oncology and Hematology, N. Ulianov Chuvash State University, Cheboksary, Chuvashia, Russia.

Galina Y Miasnikova (GY)

Department of Hematology and Chemotherapy, Chuvash Republic Clinical Hospital, Cheboksary, Chuvashia, Russia.

Tomas Ganz (T)

Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
ORCID: 0000-0002-2830-5469

Josef T Prchal (JT)

Department of Medicine, University of Utah, VAH, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.
ORCID: 0000-0002-8019-2940

Victor R Gordeuk (VR)

Division of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
ORCID: 0000-0003-4725-7295

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Hémopathies et maladies lymphatiques › Hémopathies › Polyglobulie › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Transferrines › Transferrine › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéine Von Hippel-Lindau supresseur de tumeur › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Increased transferrin protects from thrombosis...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Facteurs de stimulation des colonies › Érythropoïétine › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Ferritines › Increased transferrin protects from thrombosis...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme du fer › Carences en fer › Increased transferrin protects from thrombosis...