Pyroptosis and the cellular consequences of gasdermin pores.
Gasdermin
Inflammasome
Inflammation
Pyroptosis
Regulated cell death
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
14
04
2023
revised:
13
06
2023
accepted:
27
06
2023
pmc-release:
01
09
2024
medline:
21
8
2023
pubmed:
12
7
2023
entrez:
12
7
2023
Statut:
ppublish
Résumé
The family of gasdermin proteins plays a key role in the host response against external and internal pathogenic signals by mediating the form of inflammatory regulated cell death known as pyroptosis. One of the most well-studied gasdermins within innate immunity is gasdermin D, which is cleaved, oligomerizes, and forms plasma membrane pores. Gasdermin D pores lead to a number of downstream cellular consequences including plasma membrane rupture, or cell lysis. In this review, we describe mechanisms of activation for each of the gasdermins, their cell type specificity and some disease associations. We then discuss downstream consequences of gasdermin pore formation, including cellular mechanisms of membrane repair. Finally, we present some important next steps to better understand pyroptosis and the cellular consequences of gasdermin pore formation.
Identifiants
pubmed: 37437353
pii: S1044-5323(23)00094-5
doi: 10.1016/j.smim.2023.101803
pmc: PMC10530493
mid: NIHMS1918521
pii:
doi:
Substances chimiques
Gasdermins
0
Inflammasomes
0
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
101803Subventions
Organisme : NIAID NIH HHS
ID : R01 AI162684
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI153487
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI178367
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
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