Role of lung lobar sliding on parenchymal distortion during breathing.
finite element method
lobar fissures
lobar sliding
lung mechanics
tissue mechanics
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 09 2023
01 09 2023
Historique:
pmc-release:
01
09
2024
medline:
14
8
2023
pubmed:
13
7
2023
entrez:
13
7
2023
Statut:
ppublish
Résumé
Sliding between lung lobes along lobar fissures is a poorly understood aspect of lung mechanics. The objective of this study was to test the hypothesis that lobar sliding helps reduce distortion in the lung parenchyma during breathing. Finite element models of left lungs with geometries and boundary conditions derived from medical images of human subjects were developed. Effect of lobar sliding was studied by comparing nonlinear finite elastic contact mechanics simulations that allowed and disallowed lobar sliding. Lung parenchymal distortion during simulated breath-holds and tidal breathing was quantified with the model's spatial mean anisotropic deformation index (ADI), a measure of directional preference in volume change that varies spatially in the lung. Models that allowed lobar sliding had significantly lower mean ADI (i.e., lesser parenchymal distortion) than models that disallowed lobar sliding under simulations of both tidal breathing (5.3% median difference,
Identifiants
pubmed: 37439240
doi: 10.1152/japplphysiol.00631.2022
pmc: PMC10538991
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
534-541Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142625
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL144461
Pays : United States
Références
Int J Radiat Oncol Biol Phys. 2007 Jul 1;68(3):650-3
pubmed: 17445997
N Engl J Med. 2000 May 4;342(18):1301-8
pubmed: 10793162
Indian J Chest Dis Allied Sci. 2004 Jul-Sep;46(3):179-82
pubmed: 15553206
J Mech Behav Biomed Mater. 2019 Jun;94:126-143
pubmed: 30884281
Am Rev Respir Dis. 1987 Sep;136(3):730-6
pubmed: 3307572
J Biomech. 2011 Sep 2;44(13):2489-95
pubmed: 21802086
J Biomech. 1983;16(9):679-90
pubmed: 6643540
J Biomech Eng. 2015 May;137(5):051010
pubmed: 25727935
J Appl Physiol (1985). 1987 Dec;63(6):2467-75
pubmed: 3436878
J Biomech Eng. 2019 Nov 1;141(11):
pubmed: 31233096
Ann Biomed Eng. 2014 Mar;42(3):642-50
pubmed: 24114112
J Thorac Imaging. 2004 Jul;19(3):186-91
pubmed: 15273615
J Appl Physiol (1985). 1985 Aug;59(2):481-91
pubmed: 4030600
J Appl Physiol (1985). 1985 Jan;58(1):164-72
pubmed: 3968007
Acta Biomater. 2019 Oct 1;97:513-523
pubmed: 31330329
Sci Rep. 2022 May 2;12(1):7094
pubmed: 35501363
Med Phys. 2009 May;36(5):1500-11
pubmed: 19544766
Magn Reson Imaging. 2012 Nov;30(9):1323-41
pubmed: 22770690
J Biomech. 1981;14(4):243-52
pubmed: 7240286
Med Image Comput Comput Assist Interv. 2010;13(Pt 2):578-85
pubmed: 20879362
Anat Cell Biol. 2014 Dec;47(4):253-8
pubmed: 25548723
Acad Radiol. 2016 Oct;23(10):1255-63
pubmed: 27055745
Med Image Comput Comput Assist Interv. 2009;12(Pt 1):739-46
pubmed: 20426054
Intensive Care Med. 2016 May;42(5):637-639
pubmed: 26972902
J Appl Physiol (1985). 2013 Sep 1;115(5):730-42
pubmed: 23743399
J Biomech Eng. 2012 Jan;134(1):011005
pubmed: 22482660
Med Phys. 2012 Mar;39(3):1595-608
pubmed: 22380392
J Mech Behav Biomed Mater. 2018 Jan;77:754-763
pubmed: 28822739
J Appl Physiol. 1972 Mar;32(3):332-45
pubmed: 5010043
J Appl Physiol. 1975 Nov;39(5):742-51
pubmed: 1184513
J Mech Behav Biomed Mater. 2019 Jun;94:164-175
pubmed: 30897504
Int J Chron Obstruct Pulmon Dis. 2016 Apr 13;11:765-73
pubmed: 27110109
Phys Med Biol. 2008 Jan 7;53(1):305-17
pubmed: 18182705
J Biomech Eng. 2018 Aug 1;140(8):
pubmed: 30003262
J Appl Physiol (1985). 2009 Sep;107(3):912-20
pubmed: 19589959
Med Phys. 2009 Sep;36(9):4213-22
pubmed: 19810495