Capacitation induces changes in metabolic pathways supporting motility of epididymal and ejaculated sperm.
capacitation
extracellular flux analysis
hyperactivation
metabolic profiling
sperm maturation
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2023
2023
Historique:
received:
06
02
2023
accepted:
12
06
2023
medline:
13
7
2023
pubmed:
13
7
2023
entrez:
13
7
2023
Statut:
epublish
Résumé
Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted from the cauda epididymis. Due to the differences in methods of collection, it remains unclear whether any observed differences between mouse and human sperm represent species differences or reflect the distinct maturation states of the sperm under study. Here we compare the metabolic changes during capacitation of epididymal
Identifiants
pubmed: 37440924
doi: 10.3389/fcell.2023.1160154
pii: 1160154
pmc: PMC10335746
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1160154Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD088571
Pays : United States
Informations de copyright
Copyright © 2023 Balbach, Ghanem, Violante, Kyaw, Romarowski, Cross, Visconti, Levin and Buck.
Déclaration de conflit d'intérêts
JB and LL have licensed commercialization of a panel of monoclonal antibodies directed against sAC to Millipore. LL and JB are co-founders of Sacyl Pharmaceuticals, Inc. established to develop sAC inhibitors into on-demand contraceptives. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor RF declared a shared affiliation with the author(s) AR and PV at the time of review.
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