Transposable elements in early human embryo development and embryo models.
Journal
Current opinion in genetics & development
ISSN: 1879-0380
Titre abrégé: Curr Opin Genet Dev
Pays: England
ID NLM: 9111375
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
27
01
2023
revised:
31
05
2023
accepted:
15
06
2023
medline:
15
8
2023
pubmed:
14
7
2023
entrez:
13
7
2023
Statut:
ppublish
Résumé
Transposable elements (TEs), long discounted as 'selfish genomic elements,' are increasingly appreciated as the drivers of genomic evolution, genome organization, and gene regulation. TEs are particularly important in early embryo development, where advances in stem cell technologies, in tandem with improved computational and next-generation sequencing approaches, have provided an unprecedented opportunity to study the contribution of TEs to early mammalian development. Here, we summarize advances in our understanding of TEs in early human development and expand on how new stem cell-based embryo models can be leveraged to augment this understanding.
Identifiants
pubmed: 37441874
pii: S0959-437X(23)00066-7
doi: 10.1016/j.gde.2023.102086
pii:
doi:
Substances chimiques
DNA Transposable Elements
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102086Subventions
Organisme : NICHD NIH HHS
ID : R01 HD079546
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD098278
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD058047
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.