Arylureidoaurones: Synthesis, in vitro α-glucosidase, and α-amylase inhibition activity.
Phenylureidoaurone
α-Amylase
α-Glucosidase
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
10
04
2023
revised:
14
06
2023
accepted:
28
06
2023
pubmed:
14
7
2023
medline:
14
7
2023
entrez:
13
7
2023
Statut:
ppublish
Résumé
Because of the colossal global burden of diabetes, there is an urgent need for more effective and safer drugs. We designed and synthesized a new series of aurone derivatives possessing phenylureido or bis-phenylureido moieties as α-glucosidase and α-amylase inhibitors. Most of the synthesized phenylureidoaurones have demonstrated superior inhibition activities (IC
Identifiants
pubmed: 37442042
pii: S0045-2068(23)00370-X
doi: 10.1016/j.bioorg.2023.106709
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106709Informations de copyright
Copyright © 2023. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Latifeh Navidpour reports financial support was provided by Tehran University of Medical Sciences.