Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
13 07 2023
13 07 2023
Historique:
received:
12
12
2022
accepted:
03
07
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
13
7
2023
Statut:
epublish
Résumé
Transient stress experiences not only trigger acute stress responses, but can also have long-lasting effects on cellular functions. In Caenorhabditis elegans, a brief exposure to heat shock during early adulthood extends lifespan and improves stress resistance, a phenomenon known as heat hormesis. Here, we investigated the prolonged effect of hormetic heat stress on the transcriptome of worms and found that the canonical heat shock response is followed by a profound transcriptional reprogramming in the post-stress period. This reprogramming relies on the endoribonuclease ENDU-2 but not the heat shock factor 1. ENDU-2 co-localizes with chromatin and interacts with RNA polymerase II, enabling specific regulation of transcription after the stress period. Failure to activate the post-stress response does not affect the resistance of animals to heat shock but eliminates the beneficial effects of hormetic heat stress. In summary, our work discovers that the RNA-binding protein ENDU-2 mediates the long-term impacts of transient heat stress via reprogramming transcriptome after stress exposure.
Identifiants
pubmed: 37443152
doi: 10.1038/s41467-023-39882-8
pii: 10.1038/s41467-023-39882-8
pmc: PMC10345090
doi:
Substances chimiques
Caenorhabditis elegans Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4176Subventions
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Informations de copyright
© 2023. The Author(s).
Références
J Cell Biol. 2014 Oct 13;207(1):41-57
pubmed: 25287301
Front Oncol. 2021 Feb 05;10:522332
pubmed: 33614471
PLoS Genet. 2018 Aug 10;14(8):e1007559
pubmed: 30096138
Nucleic Acids Res. 2018 Jul 2;46(W1):W537-W544
pubmed: 29790989
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
BMC Bioinformatics. 2016 Sep 13;17(1):366
pubmed: 27618863
Exp Gerontol. 2006 Oct;41(10):935-9
pubmed: 17067771
Nat Commun. 2017 Feb 15;8:14337
pubmed: 28198373
Genetics. 1974 May;77(1):71-94
pubmed: 4366476
Curr Protoc. 2021 Jul;1(7):e187
pubmed: 34242493
Int Immunol. 2023 Apr 4;35(4):181-196
pubmed: 36409527
G3 (Bethesda). 2014 Mar 20;4(3):471-83
pubmed: 24402584
Int J Mol Sci. 2022 Aug 20;23(16):
pubmed: 36012666
Cell. 2019 Jun 27;178(1):107-121.e18
pubmed: 31251911
Cell. 2009 Oct 2;139(1):123-34
pubmed: 19804758
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
PLoS One. 2017 Dec 11;12(12):e0189445
pubmed: 29228038
Dose Response. 2006 May 22;3(4):533-46
pubmed: 18648625
Genome Biol. 2014;15(12):550
pubmed: 25516281
Exp Gerontol. 2021 Oct 15;154:111509
pubmed: 34363927
Sci Adv. 2022 Dec 9;8(49):eabq3970
pubmed: 36490338
EMBO J. 2021 Jun 1;40(11):e104123
pubmed: 33511665
PLoS Genet. 2019 Apr 29;15(4):e1008122
pubmed: 31034475
Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):8823-8828
pubmed: 30104389
Cold Spring Harb Symp Quant Biol. 2011;76:91-9
pubmed: 22371371
Bio Protoc. 2018 Oct 20;8(20):
pubmed: 30467549
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2153-8
pubmed: 20133860
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Nat Commun. 2019 Dec 11;10(1):5648
pubmed: 31827090
Environ Pollut. 2020 Jun;261:114081
pubmed: 32062098
Sci Adv. 2021 Jan 1;7(1):
pubmed: 33523838
Metallomics. 2020 Jul 22;12(7):1142-1158
pubmed: 32453327
Nat Protoc. 2016 Dec;11(12):2301-2319
pubmed: 27809316
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
BMC Genomics. 2016 Aug 05;17:559
pubmed: 27496166
Am J Physiol Cell Physiol. 2011 Apr;300(4):C723-42
pubmed: 21209361
Cell Rep. 2020 Feb 11;30(6):1848-1861.e5
pubmed: 32049015
Life (Basel). 2021 Jun 17;11(6):
pubmed: 34204549
Mol Cell Proteomics. 2014 Sep;13(9):2513-26
pubmed: 24942700
Elife. 2019 Sep 18;8:
pubmed: 31532389
MicroPubl Biol. 2018 Mar 27;2018:
pubmed: 32550381
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
Biogerontology. 2006 Aug;7(4):221-30
pubmed: 16826446
Nat Commun. 2021 Feb 24;12(1):1262
pubmed: 33627668
Cell Host Microbe. 2012 Apr 19;11(4):375-86
pubmed: 22520465
Electrophoresis. 2012 Jan;33(2):366-9
pubmed: 22222980
J Biol Chem. 2008 Dec 12;283(50):34712-9
pubmed: 18936097
J Biol Chem. 2003 Apr 11;278(15):13026-32
pubmed: 12571235