The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets.
Journal
Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
21
03
2022
accepted:
30
05
2023
medline:
14
8
2023
pubmed:
14
7
2023
entrez:
13
7
2023
Statut:
ppublish
Résumé
Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism, but the molecular mechanisms mediating LD degradation by selective autophagy (lipophagy) are unknown. Here we identify spartin as a receptor localizing to LDs and interacting with core autophagy machinery, and we show that spartin is required to deliver LDs to lysosomes for triglyceride mobilization. Mutations in SPART (encoding spartin) lead to Troyer syndrome, a form of complex hereditary spastic paraplegia
Identifiants
pubmed: 37443287
doi: 10.1038/s41556-023-01178-w
pii: 10.1038/s41556-023-01178-w
pmc: PMC10415183
doi:
Substances chimiques
Cell Cycle Proteins
0
Carrier Proteins
0
Triglycerides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1101-1110Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM097194
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM124348
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG068423
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2023. The Author(s).
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