Microvascular Thrombosis and Liver Fibrosis Progression: Mechanisms and Clinical Applications.
ADAMTS-13
coagulation
fibrosis
hepatic stellate cells
liver cirrhosis
microthrombosis
parenchymal extinction
platelets
von Willebrand factor
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
24 Jun 2023
24 Jun 2023
Historique:
received:
09
05
2023
revised:
14
06
2023
accepted:
16
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Fibrosis is an unavoidable consequence of chronic inflammation. Extracellular matrix deposition by fibroblasts, stimulated by multiple pathways, is the first step in the onset of chronic liver disease, and its propagation promotes liver dysfunction. At the same time, chronic liver disease is characterized by alterations in primary and secondary hemostasis but unlike previously thought, these changes are not associated with an increased risk of bleeding complications. In recent years, the role of coagulation imbalance has been postulated as one of the main mechanisms promoting hepatic fibrogenesis. In this review, we aim to investigate the function of microvascular thrombosis in the progression of liver disease and highlight the molecular and cellular networks linking hemostasis to fibrosis in this context. We analyze the predictive and prognostic role of coagulation products as biomarkers of liver decompensation (ascites, variceal hemorrhage, and hepatic encephalopathy) and liver-related mortality. Finally, we evaluate the current evidence on the application of antiplatelet and anticoagulant therapies for prophylaxis of hepatic decompensation or prevention of the progression of liver fibrosis.
Identifiants
pubmed: 37443746
pii: cells12131712
doi: 10.3390/cells12131712
pmc: PMC10341358
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Surg Res. 2020 Feb;246:568-583
pubmed: 31653415
Nat Med. 2019 Apr;25(4):641-655
pubmed: 30936549
Platelets. 2022 Feb 17;33(2):212-218
pubmed: 34806523
Thromb Haemost. 2008 Feb;99(2):305-15
pubmed: 18278179
J Hepatol. 2017 Jan;66(1):212-227
pubmed: 27423426
Circ Res. 2007 Jun 22;100(12):1686-95
pubmed: 17585076
Hepatology. 2010 Apr;51(4):1345-53
pubmed: 20162727
Biomed Rep. 2017 Sep;7(3):277-285
pubmed: 28894574
Adv Nephrol Necker Hosp. 2000;30:71-81
pubmed: 11068635
Hepatology. 2015 Feb;61(2):648-59
pubmed: 25142214
Res Pract Thromb Haemost. 2020 Jun 25;4(5):906-917
pubmed: 32685902
Alcohol Clin Exp Res. 2007 Jan;31(1 Suppl):S27-35
pubmed: 17331163
Gut. 2015 Sep;64(9):1434-43
pubmed: 25500203
Hum Gene Ther. 2006 Jun;17(6):589-600
pubmed: 16776568
N Engl J Med. 2021 Jun 17;384(24):2317-2330
pubmed: 34133861
Pharmacol Rep. 2015 Aug;67(4):689-94
pubmed: 26321269
Blood. 2020 Sep 3;136(10):1169-1179
pubmed: 32597954
Biochem J. 1998 Jul 1;333 ( Pt 1):121-7
pubmed: 9639571
Front Med (Lausanne). 2022 May 16;9:866746
pubmed: 35652066
Hepatology. 2010 Jul;52(1):249-55
pubmed: 20578143
Platelets. 2021 Apr 3;32(3):314-324
pubmed: 32896192
J Biol Chem. 2001 Nov 2;276(44):41059-63
pubmed: 11557746
Antioxid Redox Signal. 2011 Sep 1;15(5):1449-61
pubmed: 20919941
J Clin Invest. 2003 Jul;112(1):58-66
pubmed: 12840059
Front Med (Lausanne). 2022 Jan 11;8:814496
pubmed: 35087852
Dig Liver Dis. 2022 May;54(5):565-571
pubmed: 35093272
Gastroenterology. 2018 Nov;155(5):1564-1577
pubmed: 30055171
Dig Dis Sci. 2007 May;52(5):1187-93
pubmed: 17372820
Am J Gastroenterol. 2017 Feb;112(2):274-281
pubmed: 27801884
Indian J Gastroenterol. 2022 Apr;41(2):119-126
pubmed: 35318571
Life Sci. 2019 Aug 15;231:116522
pubmed: 31158377
J Clin Med. 2022 Mar 26;11(7):
pubmed: 35407443
Gut. 2008 Nov;57(11):1583-91
pubmed: 18596193
Eur Rev Med Pharmacol Sci. 2020 Dec;24(24):13072-13088
pubmed: 33378061
Sci Rep. 2021 Jul 28;11(1):15308
pubmed: 34321503
J Pharmacol Exp Ther. 2003 May;305(2):417-25
pubmed: 12606620
Ann Surg. 2008 Nov;248(5):821-8
pubmed: 18948810
N Engl J Med. 2015 Mar 19;372(12):1138-49
pubmed: 25785971
Toxicol Sci. 2016 Dec;154(2):381-391
pubmed: 27613713
Dig Dis Sci. 2019 Jan;64(1):102-112
pubmed: 30288660
Nature. 1998 Aug 13;394(6694):690-4
pubmed: 9716134
Arterioscler Thromb Vasc Biol. 2006 May;26(5):1185-9
pubmed: 16514085
J Thromb Haemost. 2018 Jun;16(6):1132-1140
pubmed: 29577605
J Thromb Thrombolysis. 2021 Jul;52(1):9-17
pubmed: 33534029
Haemostasis. 1993;23(1):58-64
pubmed: 8477909
Proc Am Thorac Soc. 2012 Jul;9(3):96-101
pubmed: 22802281
Biochem Biophys Res Commun. 2004 Jan 2;313(1):212-6
pubmed: 14672719
Hepatology. 2005 Mar;41(3):553-8
pubmed: 15726661
Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G304-10
pubmed: 10915638
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2165-72
pubmed: 22753481
Chem Biol Interact. 2022 Feb 25;354:109809
pubmed: 35031271
J Am Heart Assoc. 2020 Jun 16;9(12):e015616
pubmed: 32495720
Blood. 2003 Nov 1;102(9):3224-31
pubmed: 12869501
J Hepatol. 2015 Jan;62(1):18-23
pubmed: 25135867
Blood. 2016 Jul 7;128(1):104-9
pubmed: 27207787
Pharmacol Res. 2005 Jan;51(1):59-67
pubmed: 15519536
Platelets. 2022 Feb 17;33(2):219-228
pubmed: 33577391
Nature. 2019 Nov;575(7783):512-518
pubmed: 31597160
Aliment Pharmacol Ther. 2020 Sep;52(6):1060-1068
pubmed: 32628793
Am J Respir Crit Care Med. 2011 Jun 15;183(12):1703-14
pubmed: 21471103
Hepatology. 2017 Jun;65(6):2031-2044
pubmed: 28142199
J Gastroenterol Hepatol. 2008 Sep;23(9):1403-9
pubmed: 18005014
J Hepatol. 2007 Feb;46(2):286-94
pubmed: 17166617
J Cell Mol Med. 2015 Jun;19(6):1346-56
pubmed: 25689283
Liver Int. 2015 Jan;35(1):37-45
pubmed: 25113276
Aliment Pharmacol Ther. 2014 Feb;39(3):331-8
pubmed: 24308724
Gut. 2020 Aug;69(8):1545-1547
pubmed: 32414813
J Hepatol. 2022 May;76(5):1090-1099
pubmed: 35066090
Semin Liver Dis. 2010 Aug;30(3):211-4
pubmed: 20665373
Blood. 2004 Jul 1;104(1):100-6
pubmed: 15026315
Liver Int. 2020 Sep;40(9):2110-2116
pubmed: 32654359
Hepatology. 2021 May;73(5):1882-1891
pubmed: 32767567
World J Gastroenterol. 2005 Nov 28;11(44):6936-40
pubmed: 16437596
J Immunol. 2011 Apr 1;186(7):4147-55
pubmed: 21368224
Physiol Rev. 2023 Jan 1;103(1):717-785
pubmed: 35901239
J Biochem. 2001 Oct;130(4):475-80
pubmed: 11574066
BMC Gastroenterol. 2018 May 8;18(1):60
pubmed: 29739329
Hepatol Res. 2021 Sep;51(9):1000-1006
pubmed: 34260803
Can J Gastroenterol Hepatol. 2020 Dec 11;2020:8887574
pubmed: 33381477
Hepatology. 1995 May;21(5):1232-7
pubmed: 7737628
Trends Immunol. 2021 Jun;42(6):508-522
pubmed: 33906793
J Hepatol. 2023 Jul;79(1):e25-e27
pubmed: 36603663
Front Immunol. 2022 Nov 14;13:1039843
pubmed: 36451834
Front Oncol. 2021 Jul 21;11:643815
pubmed: 34367949
Front Cardiovasc Med. 2021 Feb 02;8:636843
pubmed: 33604359
J Hepatol. 2015 Jul;63(1):277-8
pubmed: 25725439
Liver Int. 2011 Jan;31(1):75-82
pubmed: 20958919
BMC Med. 2022 Sep 29;20(1):335
pubmed: 36171606
N Engl J Med. 2020 Mar 12;382(11):1018-1028
pubmed: 32160663
Hepatology. 2004 Feb;39(2):365-75
pubmed: 14767989
Lab Invest. 2005 Jun;85(6):780-8
pubmed: 15806136
Int J Hematol. 2002 Jan;75(1):25-34
pubmed: 11843286
Alcohol Clin Exp Res. 2010 Feb;34 Suppl 1:S25-33
pubmed: 19094193
Trends Cardiovasc Med. 2002 May;12(4):149-54
pubmed: 12069753
Nat Rev Nephrol. 2019 Feb;15(2):87-108
pubmed: 30607032
Biology (Basel). 2023 Jan 20;12(2):
pubmed: 36829443
J Clin Invest. 1989 Dec;84(6):1786-93
pubmed: 2592560
J Hepatol. 2016 Apr;64(4):834-42
pubmed: 26686269
J Hepatol. 2013 Jan;58(1):98-103
pubmed: 22989565
Hepatology. 1983 Nov-Dec;3(6):964-73
pubmed: 6313508
Gastroenterology. 2019 Jul;157(1):193-209.e9
pubmed: 30872106
J Hepatol. 2010 Oct;53(4):702-12
pubmed: 20633948
Nature. 2001 Oct 4;413(6855):488-94
pubmed: 11586351
Gastroenterology. 2009 Dec;137(6):2105-11
pubmed: 19706293
Am J Pathol. 2012 Oct;181(4):1287-95
pubmed: 22841818
Blood. 2015 Mar 26;125(13):2019-28
pubmed: 25712991
Blood Rev. 1993 Mar;7(1):52-62
pubmed: 8467233
J Thromb Haemost. 2012 Sep;10(9):1823-9
pubmed: 22712870
Blood Rev. 2021 Mar;46:100733
pubmed: 32682574
Br J Haematol. 2007 Aug;138(4):534-40
pubmed: 17608762
Gut. 2011 Aug;60(8):1133-8
pubmed: 21427197
Blood. 2005 Aug 1;106(3):922-4
pubmed: 15855280
Best Pract Res Clin Gastroenterol. 2011 Apr;25(2):195-206
pubmed: 21497738
J Hepatol. 2016 Sep;65(3):608-17
pubmed: 27151183
Am J Pathol. 2011 Nov;179(5):2278-89
pubmed: 21907177
N Engl J Med. 2002 Aug 22;347(8):589-600
pubmed: 12192020
Am J Pathol. 2010 Dec;177(6):2837-49
pubmed: 21037076
World J Gastroenterol. 2017 Sep 21;23(35):6412-6419
pubmed: 29085190
J Hepatol. 2017 Nov;67(5):950-956
pubmed: 28716745
Liver Int. 2018 Jan;38(1):102-112
pubmed: 28665498
Gastroenterology. 2014 Dec;147(6):1378-92
pubmed: 25173753
J Thromb Haemost. 2015 Jan;13(1):57-71
pubmed: 25353084
J Thromb Haemost. 2014 Jan;12(1):36-42
pubmed: 24118899
J Exp Med. 2004 May 17;199(10):1305-15
pubmed: 15136591
Alcohol Clin Exp Res. 2005 Dec;29(12 Suppl):264S-71S
pubmed: 16385234
J Biochem Mol Toxicol. 2019 May;33(5):e22287
pubmed: 30719803
Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11902-7
pubmed: 12181489
Front Immunol. 2022 Oct 27;13:1037645
pubmed: 36389830
Hepatology. 2018 Oct;68(4):1347-1360
pubmed: 29631332
Hepatol Res. 2012 Jan;42(1):91-102
pubmed: 21988364
J Hepatol. 2016 Nov;65(5):921-928
pubmed: 27297911
Gastroenterol Rep (Oxf). 2022 Nov 07;10:goac065
pubmed: 36381222
Respir Res. 2003;4:13
pubmed: 14624704
Gastroenterology. 2009 May;136(5):1651-8
pubmed: 19208350
J Hepatol. 2002 Mar;36(3):362-9
pubmed: 11867180
Front Immunol. 2022 Jun 28;13:936196
pubmed: 35837401
Gastroenterology. 2016 Feb;150(2):430-40.e1
pubmed: 26484707
Hepatology. 1995 May;21(5):1238-47
pubmed: 7737629
Gastroenterology. 2012 Nov;143(5):1253-1260.e4
pubmed: 22819864
EBioMedicine. 2020 Aug;58:102925
pubmed: 32745993
Clin Res Hepatol Gastroenterol. 2014 Oct;38(5):570-6
pubmed: 25130796
Virchows Arch. 2006 Jan;448(1):46-51
pubmed: 16193294
Hepatology. 1985 Jul-Aug;5(4):649-60
pubmed: 2991107
Microvasc Res. 1988 Sep;36(2):140-9
pubmed: 2846988
Cells. 2022 Mar 29;11(7):
pubmed: 35406712
Hepatology. 2012 Oct;56(4):1439-47
pubmed: 22532296
Aliment Pharmacol Ther. 2018 Apr;47(7):980-988
pubmed: 29377193
Gastroenterology. 2010 Jun;138(7):2487-98, 2498.e1-7
pubmed: 20206174
Hepatology. 2002 May;35(5):1010-21
pubmed: 11981751
Hepatology. 2007 Jul;46(1):242-53
pubmed: 17596891
BMJ Open. 2019 Aug 30;9(8):e025656
pubmed: 31473610
Nat Med. 2000 Dec;6(12):1348-54
pubmed: 11100119
Thromb Haemost. 2008 Jun;99(6):1019-29
pubmed: 18521503
J Hepatol. 2013 Nov;59(5):1094-106
pubmed: 23811302
Intern Emerg Med. 2012 Apr;7(2):139-44
pubmed: 21298360
Genes (Basel). 2022 Dec 22;14(1):
pubmed: 36672763
Int J Mol Sci. 2021 Apr 26;22(9):
pubmed: 33925804
Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G226-35
pubmed: 17962354