Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex.
ALK
NRP-1
RPTPZ1
cerebellum
development
human
pleiotrophin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 Jun 2023
27 Jun 2023
Historique:
received:
05
05
2023
revised:
19
06
2023
accepted:
24
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
During embryonic and fetal development, the cerebellum undergoes several histological changes that require a specific microenvironment. Pleiotrophin (PTN) has been related to cerebral and cerebellar cortex ontogenesis in different species. PTN signaling includes PTPRZ1, ALK, and NRP-1 receptors, which are implicated in cell differentiation, migration, and proliferation. However, its involvement in human cerebellar development has not been described so far. Therefore, we investigated whether PTN and its receptors were expressed in the human cerebellar cortex during fetal and early neonatal development. The expression profile of PTN and its receptors was analyzed using an immunohistochemical method. PTN, PTPRZ1, and NRP-1 were expressed from week 17 to the postnatal stage, with variable expression among granule cell precursors, glial cells, and Purkinje cells. ALK was only expressed during week 31. These results suggest that, in the fetal and neonatal human cerebellum, PTN is involved in cell communication through granule cell precursors, Bergmann glia, and Purkinje cells via PTPRZ1, NRP-1, and ALK signaling. This communication could be involved in cell proliferation and cellular migration. Overall, the present study represents the first characterization of PTN, PTPRZ1, ALK, and NRP-1 expression in human tissues, suggesting their involvement in cerebellar cortex development.
Identifiants
pubmed: 37443767
pii: cells12131733
doi: 10.3390/cells12131733
pmc: PMC10341181
pii:
doi:
Substances chimiques
pleiotrophin
134034-50-7
Cytokines
0
Carrier Proteins
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
PTPRZ1 protein, human
EC 3.1.3.48
Receptor-Like Protein Tyrosine Phosphatases, Class 5
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Guadalajara
ID : 269639-PROSNI
Organisme : University of Guadalajara
ID : PROINPEP 2021
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : 2019-552265
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