Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes.
biosynthesis
efflux
fibroblast-like synoviocytes
functions
inflammation
lipidomics
lipids
lysophosphatidylcholine
lysophospholipid
orbitrap
osteoarthritis
phospholipids
proteomics
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
29 Jun 2023
29 Jun 2023
Historique:
received:
01
06
2023
revised:
23
06
2023
accepted:
27
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Synovial fluid (SF) from human knee joints with osteoarthritis (OA) has elevated levels of lysophosphatidylcholine (LPC) species, but their functional role is not well understood. This in vitro study was designed to test the hypothesis that various LPCs found elevated in OA SF and their metabolites, lysophosphatidic acids (LPAs), modulate the abundance of proteins and phospholipids (PLs) in human fibroblast-like synoviocytes (FLSs), with even minute chemical variations in lysophospholipids determining the extent of regulation. Cultured FLSs (
Identifiants
pubmed: 37443777
pii: cells12131743
doi: 10.3390/cells12131743
pmc: PMC10340184
pii:
doi:
Substances chimiques
Lysophospholipids
0
Lysophosphatidylcholines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dr. Reinhold Bisinger Foundation (DRB)
ID : 39/2017
Organisme : Deutsche Forschungsgemeinschaft
ID : 426546972
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