Analysis of the Mutational Landscape of Osteosarcomas Identifies Genes Related to Metastasis and Prognosis and Disrupted Biological Pathways of Immune Response and Bone Development.
DMD
KNL1
PTPRQ
RB1
TNFRSF11B
TP53
ZFHX4
chromoanasynthesis
chromothripsis
osteosarcoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Jun 2023
21 Jun 2023
Historique:
received:
02
05
2023
revised:
08
06
2023
accepted:
10
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Osteosarcoma (OS) is the most prevalent type of bone tumor, but slow progress has been achieved in disentangling the full set of genomic events involved in its initiation and progression. We assessed by NGS the mutational spectrum of 28 primary OSs from Brazilian patients, and identified 445 potentially deleterious SNVs/indels and 1176 copy number alterations (CNAs).
Identifiants
pubmed: 37445641
pii: ijms241310463
doi: 10.3390/ijms241310463
pmc: PMC10342084
pii:
doi:
Substances chimiques
PTPRQ protein, human
EC 3.1.3.48
Receptor-Like Protein Tyrosine Phosphatases, Class 3
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : São Paulo Research Foundation
ID : 2013/08028-1
Organisme : São Paulo Research Foundation
ID : 2014/10250-7
Organisme : São Paulo Research Foundation
ID : 2018/21047-9
Organisme : National Council for Scientific and Technological Development
ID : 305806/2019-0
Organisme : National Council for Scientific and Technological Development
ID : 311141/2021-8
Organisme : Coordenação de Aperfeicoamento de Pessoal de Nível Superior
ID : 88887.508357/2020-00
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