BDNF and Cognitive Function in Chilean Schizophrenic Patients.
BDNF plasma levels
Montreal Cognitive Assessment (MoCA)
brain-derived neurotrophic factor
cognition
cognition biomarker
cognitive impairment
neurotrophins
schizophrenia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jun 2023
24 Jun 2023
Historique:
received:
21
04
2023
revised:
16
06
2023
accepted:
19
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Despite cognitive symptoms being very important in schizophrenia, not every schizophrenic patient has a significant cognitive deficit. The molecular mechanisms underlying the different degrees of cognitive functioning in schizophrenic patients are not sufficiently understood. We studied the relation between brain-derived neurotrophic factor (BDNF) and cognitive functioning in two groups of schizophrenic patients with different cognitive statuses. According to the Montreal Cognitive Assessment (MoCA) results, the schizophrenic patients were classified into two subgroups: normal cognition (26 or more) and cognitive deficit (25 or less). We measured their plasma BDNF levels using ELISAs. The statistical analyses were performed using Spearman's Rho and Kruskal-Wallis tests. We found a statistically significant positive correlation between the plasma BDNF levels and MoCA score (
Identifiants
pubmed: 37445746
pii: ijms241310569
doi: 10.3390/ijms241310569
pmc: PMC10341589
pii:
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agencia Nacional de Investigación y Desarrollo
ID : 11231216
Organisme : Ministry of Economy, Development and Tourism
ID : P09-015-F
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