Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells.

Humans Glucosylceramidase / genetics Rotenone / pharmacology HEK293 Cells Hydrogen Peroxide / metabolism alpha-Synuclein / metabolism Parkinson Disease / metabolism Lysosomes / metabolism Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 / metabolism
HEK-293 LRRK2 Parkinson’s autophagy conduritol-β-epoxide glucocerebrosidase rotenone

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 Jun 2023
Historique:
received: 29 05 2023
revised: 18 06 2023
accepted: 19 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra and the intraneuronal presence of Lewy bodies (LBs), composed of aggregates of phosphorylated alpha-synuclein at residue Ser

Identifiants

DOI: 10.3390/ijms241310589 PMID: 37445771 PMC: PMC10341970
pubmed: 37445771
pii: ijms241310589
doi: 10.3390/ijms241310589
pmc: PMC10341970
pii:
doi:

Substances chimiques

Glucosylceramidase EC 3.2.1.45
Rotenone 03L9OT429T
Hydrogen Peroxide BBX060AN9V
alpha-Synuclein 0
LRRK2 protein, human EC 2.7.11.1
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 EC 2.7.11.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Colciencias
ID : 1115-844-67799

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Auteurs

Laura Patricia Perez-Abshana (LP)

Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.

Miguel Mendivil-Perez (M)

Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.

Carlos Velez-Pardo (C)

Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.

Marlene Jimenez-Del-Rio (M)

Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.
ORCID: 0000-0003-3477-2386

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › Glucosylceramidase › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques avec 4 noyaux ou plus › Roténone › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › alpha-Synucléine › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Rotenone Blocks the Glucocerebrosidase Enzyme...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées à la maladie de Parkinson › Leucine-rich repeat serine-threonine protein kinase-2 › Rotenone Blocks the Glucocerebrosidase Enzyme...