Pharmacogenetic Guided Opioid Therapy Improves Chronic Pain Outcomes and Comorbid Mental Health: A Randomized, Double-Blind, Controlled Study.

Humans Analgesics, Opioid / adverse effects Pharmacogenetics Chronic Pain / drug therapy Cytochrome P-450 CYP2D6 / genetics Catechol O-Methyltransferase / genetics Quality of Life Mental Health Practice Patterns, Physicians' Comorbidity Receptors, Opioid, mu / genetics
COMT CYP2D6 OPRM1 chronic pain opioids pharmacogenetics

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
28 Jun 2023
Historique:
received: 20 05 2023
revised: 20 06 2023
accepted: 25 06 2023
medline: 17 7 2023
pubmed: 14 7 2023
entrez: 14 7 2023
Statut: epublish

Résumé

Interindividual variability in analgesic response is at least partly due to well-characterized polymorphisms that are associated with opioid dosing and adverse outcomes. The Clinical Pharmacogenetics Implementation Consortium (CPIC) has put forward recommendations for the

Identifiants

DOI: 10.3390/ijms241310754 PMID: 37445931 PMC: PMC10341655
pubmed: 37445931
pii: ijms241310754
doi: 10.3390/ijms241310754
pmc: PMC10341655
pii:
doi:

Substances chimiques

Analgesics, Opioid 0
Cytochrome P-450 CYP2D6 EC 1.14.14.1
Catechol O-Methyltransferase EC 2.1.1.6
Receptors, Opioid, mu 0

Types de publication

Randomized Controlled Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
ID : AES, ICI20/00146

Références

Dan Med J. 2020 Jul 1;67(7):
pubmed: 32734883
Genet Med. 2017 Jan;19(1):69-76
pubmed: 27388693
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13
pubmed: 9689128
Biomolecules. 2021 Oct 15;11(10):
pubmed: 34680158
CNS Neurol Disord Drug Targets. 2012 May;11(3):264-72
pubmed: 22483292
J Manag Care Spec Pharm. 2020 Dec;26(12):1597-1602
pubmed: 33252002
Pain Res Manag. 2020 Nov 20;2020:8847777
pubmed: 33273995
Trends Mol Med. 2005 Feb;11(2):82-9
pubmed: 15694871
Intensive Care Med. 2014 Aug;40(8):1177-8
pubmed: 24968714
OMICS. 2017 Jan;21(1):17-26
pubmed: 28271978
Lancet. 2018 Oct 27;392(10157):1553-1598
pubmed: 30314863
Genet Med. 2021 Apr;23(4):621-628
pubmed: 33420349
Pain Med. 2014 May;15(5):791-806
pubmed: 24517173
Clin Gastroenterol Hepatol. 2023 Jul;21(7):1781-1791.e4
pubmed: 36191836
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Farm Hosp. 2020 Apr 14;44(3):109-113
pubmed: 32452310
Pharmacol Res Perspect. 2018 Jul 05;6(4):e00419
pubmed: 29992026
J Pers Med. 2022 Mar 08;12(3):
pubmed: 35330421
Biomedicines. 2022 Oct 02;10(10):
pubmed: 36289731
Toxicol Appl Pharmacol. 2018 May 1;346:37-44
pubmed: 29555325
Lancet. 2023 Feb 4;401(10374):347-356
pubmed: 36739136
Pain. 1998 May;76(1-2):27-33
pubmed: 9696456
Clin Pharmacol Ther. 2021 Oct;110(4):888-896
pubmed: 33387367
Pain Pract. 2019 Nov;19(8):836-847
pubmed: 31269327
Nurse Pract. 2021 Apr 1;46(4):12-19
pubmed: 33739321
Osteoarthritis Cartilage. 2022 Dec;30(12):1561-1574
pubmed: 35961505
Mol Psychiatry. 2006 May;11(5):446-58
pubmed: 16505837
J Psychiatry Neurosci. 2013 Nov;38(6):366-80
pubmed: 23527885
Clin Pharmacol Ther. 2006 Jan;79(1):35-48
pubmed: 16413240
BMC Musculoskelet Disord. 2022 Dec 22;23(1):1115
pubmed: 36544130
Curr Psychiatry Rep. 2018 Mar 5;20(2):12
pubmed: 29504088
Curr Top Behav Neurosci. 2011;8:119-40
pubmed: 21769726
Am J Hosp Palliat Care. 2011 Aug;28(5):378-83
pubmed: 21622486
Arch Pharm Res. 2018 Mar;41(3):288-298
pubmed: 29196917
Eur J Clin Pharmacol. 2018 Nov;74(11):1461-1469
pubmed: 30051214
Pain. 2009 Jul;144(1-2):119-24
pubmed: 19395173
Forensic Sci Int. 2014 May;238:125-32
pubmed: 24709712
Clin Pharmacol Ther. 2014 Apr;95(4):376-82
pubmed: 24458010
Clin Pharmacol Ther. 2011 Mar;89(3):464-7
pubmed: 21270786
Eur J Clin Pharmacol. 2012 Jan;68(1):55-64
pubmed: 21735164
Pharmacogenomics. 2017 Mar;18(4):337-348
pubmed: 28244808
Genet Med. 2019 Aug;21(8):1842-1850
pubmed: 30670877
Pain Pract. 2008 Jul-Aug;8(4):287-313
pubmed: 18503626
Arch Pharm Res. 2018 May;41(5):554-563
pubmed: 29524157
Eur J Clin Pharmacol. 2015 Jun;71(6):681-686
pubmed: 25948472
Clin Pharmacol Ther. 2008 Feb;83(2):234-42
pubmed: 17971818
Forensic Sci Int. 2016 Aug;265:153-9
pubmed: 26926096
Folia Med (Plovdiv). 2020 Dec 31;62(4):645-654
pubmed: 33415907
Expert Opin Drug Metab Toxicol. 2022 Apr;18(4):261-275
pubmed: 35649041
Bratisl Lek Listy. 2012;113(3):152-5
pubmed: 22428763
Science. 2003 Feb 21;299(5610):1240-3
pubmed: 12595695
Health Qual Life Outcomes. 2003 Aug 01;1:29
pubmed: 12914662
Clin Pharmacol Ther. 1996 Dec;60(6):636-44
pubmed: 8988065
Eur J Clin Pharmacol. 2011 Aug;67(8):855-8
pubmed: 21691803
Pain. 2016 Aug;157(8):1618-25
pubmed: 26934512
Pharmgenomics Pers Med. 2018 Oct 24;11:179-191
pubmed: 30425549
Drug Metab Pharmacokinet. 2014;29(1):29-43
pubmed: 23759977
J Clin Pharmacol. 2011 Nov;51(11):1529-38
pubmed: 21209234
Pediatrics. 2015 Mar;135(3):e753-5
pubmed: 25647677
PLoS One. 2013;8(3):e60239
pubmed: 23555934
BMJ Open. 2021 Jun 30;11(6):e044157
pubmed: 34193479
Pain Med. 2020 Nov 1;21(11):3199-3204
pubmed: 32443139
Pharmacotherapy. 2017 Sep;37(9):1105-1121
pubmed: 28699646
Int Rev Neurobiol. 2010;95:227-79
pubmed: 21095465
Pain Med. 2009 Jul-Aug;10(5):799-805
pubmed: 19523031

Auteurs

Laura Agulló (L)

Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.
Clinical Pharmacology, Toxicology and Chemical Safety Unit, Institute of Bioengineering, Miguel Hernández University, Avda. de la Universidad s/n, 03202 Elche, Spain.
ORCID: 0000-0002-8739-0456

Isidro Aguado (I)

Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.

Javier Muriel (J)

Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.
Clinical Pharmacology, Toxicology and Chemical Safety Unit, Institute of Bioengineering, Miguel Hernández University, Avda. de la Universidad s/n, 03202 Elche, Spain.
ORCID: 0000-0003-0048-9451

César Margarit (C)

Pain Unit, Department of Health of Alicante, General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.

Alba Gómez (A)

Clinical Pharmacology, Toxicology and Chemical Safety Unit, Institute of Bioengineering, Miguel Hernández University, Avda. de la Universidad s/n, 03202 Elche, Spain.

Mónica Escorial (M)

Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.
Clinical Pharmacology, Toxicology and Chemical Safety Unit, Institute of Bioengineering, Miguel Hernández University, Avda. de la Universidad s/n, 03202 Elche, Spain.

Astrid Sánchez (A)

San Vicente del Raspeig II Health Center, c/Alicante, 78, Sant Vicent del Raspeig, 03690 Alicante, Spain.

Alicia Fernández (A)

San Vicente del Raspeig II Health Center, c/Alicante, 78, Sant Vicent del Raspeig, 03690 Alicante, Spain.

Ana M Peiró (AM)

Pharmacogenetic Unit, Clinical Pharmacology Department, Alicante Institute for Health and Biomedical Research (ISABIAL), General University Hospital of Alicante, c/Pintor Baeza, 12, 03010 Alicante, Spain.
Clinical Pharmacology, Toxicology and Chemical Safety Unit, Institute of Bioengineering, Miguel Hernández University, Avda. de la Universidad s/n, 03202 Elche, Spain.
ORCID: 0000-0002-2385-3749

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Stupéfiants › Analgésiques morphiniques › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacogénétique › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2D6 › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Catechol O-methyltransferase › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Caractéristiques de la population › Santé › Santé mentale › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Prestations des soins de santé › Types de pratiques des médecins › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Comorbidité › Pharmacogenetic Guided Opioid Therapy Improves...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur mu › Pharmacogenetic Guided Opioid Therapy Improves...