Proteoglycans in Articular Cartilage and Their Contribution to Chondral Injury and Repair Mechanisms.
articular cartilage
biomarkers
chondral injury
extracellular matrix
proteoglycans
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jun 2023
28 Jun 2023
Historique:
received:
31
05
2023
revised:
17
06
2023
accepted:
23
06
2023
medline:
17
7
2023
pubmed:
14
7
2023
entrez:
14
7
2023
Statut:
epublish
Résumé
Proteoglycans are vital components of the extracellular matrix in articular cartilage, providing biomechanical properties crucial for its proper functioning. They are key players in chondral diseases, specifically in the degradation of the extracellular matrix. Evaluating proteoglycan molecules can serve as a biomarker for joint degradation in osteoarthritis patients, as well as assessing the quality of repaired tissue following different treatment strategies for chondral injuries. Despite ongoing research, understanding osteoarthritis and cartilage repair remains unclear, making the identification of key molecules essential for early diagnosis and effective treatment. This review offers an overview of proteoglycans as primary molecules in articular cartilage. It describes the various types of proteoglycans present in both healthy and damaged cartilage, highlighting their roles. Additionally, the review emphasizes the importance of assessing proteoglycans to evaluate the quality of repaired articular tissue. It concludes by providing a visual and narrative description of aggrecan distribution and presence in healthy cartilage. Proteoglycans, such as aggrecan, biglycan, decorin, perlecan, and versican, significantly contribute to maintaining the health of articular cartilage and the cartilage repair process. Therefore, studying these proteoglycans is vital for early diagnosis, evaluating the quality of repaired cartilage, and assessing treatment effectiveness.
Identifiants
pubmed: 37446002
pii: ijms241310824
doi: 10.3390/ijms241310824
pmc: PMC10341989
pii:
doi:
Substances chimiques
Aggrecans
0
Decorin
0
Extracellular Matrix Proteins
0
Biglycan
0
Lectins, C-Type
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Arthritis Rheum. 1989 Nov;32(11):1434-42
pubmed: 2554931
J Biol Chem. 2003 Sep 26;278(39):37698-704
pubmed: 12840020
J Exp Orthop. 2015 Dec;2(1):13
pubmed: 26914881
J Orthop Res. 1987;5(4):509-22
pubmed: 3681525
Clin Interv Aging. 2017 Sep 14;12:1471-1479
pubmed: 29066871
BMC Musculoskelet Disord. 2013 May 30;14:174
pubmed: 23721417
Curr Opin Rheumatol. 2022 Jan 1;34(1):54-60
pubmed: 34652292
Osteoarthritis Cartilage. 2021 Aug;29(8):1181-1192
pubmed: 33915295
Br Med Bull. 2008;87:77-95
pubmed: 18676397
Adv Immunol. 2014;122:211-52
pubmed: 24507159
Tissue Eng Part C Methods. 2017 Nov;23(11):745-753
pubmed: 28747146
J Biol Chem. 2006 Jun 30;281(26):18257-63
pubmed: 16648631
Arthritis Res. 2001;3(6):342-7
pubmed: 11714388
Cells Tissues Organs. 2004;176(1-3):79-86
pubmed: 14745237
Cartilage. 2021 Apr;12(2):146-154
pubmed: 30827131
ACS Nano. 2016 Jan 26;10(1):1292-9
pubmed: 26757419
Ann R Coll Surg Engl. 2012 Sep;94(6):381-7
pubmed: 22943326
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Acta Biomater. 2021 Nov;135:13-26
pubmed: 34454085
J Glaucoma. 2014 Oct-Nov;23(8 Suppl 1):S20-3
pubmed: 25275899
Knee. 2002 Feb;9(1):7-10
pubmed: 11830374
Science. 2012 Nov 16;338(6109):917-21
pubmed: 23161992
ACS Nano. 2019 Oct 22;13(10):11320-11333
pubmed: 31550133
Eur Cell Mater. 2014 Mar 25;27:237-50; discussion 249-50
pubmed: 24668596
Knee Surg Sports Traumatol Arthrosc. 2023 Jul;31(7):2944-2955
pubmed: 36598512
Iowa Orthop J. 2001;21:1-7
pubmed: 11813939
Biomarkers. 2015;20(8):513-8
pubmed: 26954784
Case Rep Orthop. 2015;2015:617365
pubmed: 25628907
J Histochem Cytochem. 2012 Dec;60(12):987-96
pubmed: 23019016
Osteoarthritis Cartilage. 2010 Jul;18(7):971-80
pubmed: 20433936
J Exp Clin Cancer Res. 2022 Sep 16;41(1):276
pubmed: 36114508
Nat Rev Rheumatol. 2011 Jan;7(1):50-6
pubmed: 21119607
Adv Drug Deliv Rev. 2016 Feb 1;97:4-27
pubmed: 26562801
Int J Mol Sci. 2021 Dec 11;22(24):
pubmed: 34948124
J Exp Orthop. 2014 Dec;1(1):8
pubmed: 26914753
Orthop J Sports Med. 2019 Sep 10;7(9):2325967119867618
pubmed: 31534979
Nat Rev Mol Cell Biol. 2014 Dec;15(12):771-85
pubmed: 25370693
Sports Med Arthrosc Rev. 2006 Sep;14(3):146-54
pubmed: 17135961
J Am Soc Nephrol. 2014 Jul;25(7):1387-400
pubmed: 24762401
J Orthop Res. 2018 Feb;36(2):620-631
pubmed: 28975657
J Am Acad Orthop Surg. 2003 Nov-Dec;11(6):421-30
pubmed: 14686827
J Histochem Cytochem. 2012 Dec;60(12):885-97
pubmed: 23019015
Biomolecules. 2020 Aug 27;10(9):
pubmed: 32867198
J Histochem Cytochem. 2020 Nov;68(11):763-775
pubmed: 33131383
Int J Mol Sci. 2019 Feb 26;20(5):
pubmed: 30813547
J Biol Chem. 1974 Jul 10;249(13):4242-9
pubmed: 4277352
J Biol Chem. 2010 Jul 2;285(27):21114-25
pubmed: 20404343
Biomed Res Int. 2014;2014:452315
pubmed: 25105124
Biorheology. 1985;22(2):159-69
pubmed: 3986323
Sci Rep. 2015 Nov 09;5:16225
pubmed: 26549401
Front Oncol. 2014 Jan 13;3:327
pubmed: 24455486
J Histochem Cytochem. 2020 Nov;68(11):747-762
pubmed: 32623936
Mediators Inflamm. 2021 Mar 9;2021:5574582
pubmed: 33776572
Arthritis Res Ther. 2009;11(3):R92
pubmed: 19545413
Arthritis Res Ther. 2015 Dec 24;17:379
pubmed: 26703441
J Immunol. 2011 Nov 15;187(10):4927-33
pubmed: 22049227
Am J Pathol. 2012 Aug;181(2):380-7
pubmed: 22735579
Biomed Res Int. 2021 Nov 11;2021:3668568
pubmed: 34805399
Biochem J. 2001 Sep 15;358(Pt 3):615-26
pubmed: 11535123
Bone. 2012 Aug;51(2):278-88
pubmed: 22155587
BMC Musculoskelet Disord. 2020 Jul 03;21(1):432
pubmed: 32620156
Ann Rheum Dis. 2017 Feb;76(2):442-449
pubmed: 27377816
J Biol Chem. 1969 Jan 10;244(1):77-87
pubmed: 4237578
Int J Mol Sci. 2021 Mar 08;22(5):
pubmed: 33800241
Matrix Biol. 2018 Oct;71-72:51-69
pubmed: 29803938
Int J Exp Pathol. 2009 Dec;90(6):575-86
pubmed: 19958398
Arthritis Res Ther. 2013;15(3):R59
pubmed: 23673274
Biomolecules. 2021 Jan 13;11(1):
pubmed: 33450893
Bioessays. 2008 May;30(5):457-69
pubmed: 18404701
Indian J Med Res. 2021 Apr;153(4):453-458
pubmed: 34380791
FEBS J. 2013 May;280(10):2490-510
pubmed: 23419186
Osteoarthritis Cartilage. 2004 Nov;12(11):852-62
pubmed: 15501400
Biochemistry. 2008 Oct 28;47(43):11174-83
pubmed: 18826258
Matrix Biol. 2002 Jun;21(4):349-59
pubmed: 12128072
J Histochem Cytochem. 2012 Dec;60(12):963-75
pubmed: 22821552
Eur Cell Mater. 2016 Jul 05;32:40-57
pubmed: 27377666
Front Cell Dev Biol. 2022 Apr 01;10:856261
pubmed: 35433700
Regen Biomater. 2020 Feb;7(1):77-90
pubmed: 32153994
Int J Clin Exp Pathol. 2015 May 01;8(5):5658-65
pubmed: 26191278
Stem Cells Dev. 2016 Jun 1;25(11):836-47
pubmed: 27068010
J Mol Histol. 2019 Jun;50(3):285-294
pubmed: 30993430
J Orthop Res. 1996 Sep;14(5):681-9
pubmed: 8893759
Arthritis Rheum. 2008 Jan;58(1):15-25
pubmed: 18163481
J Mech Behav Biomed Mater. 2019 Oct;98:383-394
pubmed: 31349141
Matrix Biol. 2015 Mar;42:11-55
pubmed: 25701227
Arthritis Res Ther. 2010;12(6):R230
pubmed: 21194461
Cartilage. 2021 Dec;13(1_suppl):82S-103S
pubmed: 32713185
Br J Pharmacol. 2019 Jan;176(1):82-92
pubmed: 29510460
J Dent Res. 2009 Mar;88(3):244-8
pubmed: 19329458
Int J Mol Sci. 2021 Dec 18;22(24):
pubmed: 34948394
J Proteome Res. 2016 Feb 5;15(2):374-88
pubmed: 26632656
Matrix Biol. 1997 Aug;16(3):85-92
pubmed: 9314158
Osteoarthritis Cartilage. 2014 Jul;22(7):896-903
pubmed: 24795272